Crossmodal sensary education space for highrisk neonatal infant brains

• Project/Area Number: 17K18648
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Education and related fields
• Research Institution: Yamaguchi University
• Principal Investigator: Koshiba Mamiko 山口大学, 大学院創成科学研究科, 准教授 (90415571)
• Co-Investigator(Kenkyū-buntansha): 山内 秀雄 埼玉医科大学, 医学部, 教授 (10250226) ; 國方 徹也 埼玉医科大学, 医学部, 教授 (50195468)
• Project Period (FY): 2017-06-30 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 胎児期脳神経発達 / 行動・生理長期計測 / 遺伝と環境の相互作用 / 発達齢依存性 / 脳MRI / Diffusion Krutosis Image / リズム形成 / コミュニケーション発達 / 感覚クロスモダル機能 / 生体リズム / 社会性情動の可視化 / 環境と生体 / 脳神経発達 / 視覚・聴覚・体性感覚 / 生涯発達 / 高感受性期学習 / 照明・環境・温熱 / 社会 / 音声 / 多機能クロスモダル / 神経回路形成 / 随意性

Outline of Final Research Achievements

To support high-risk preterm infant brain development, we designed a informative communication technology (ICT) system to quantitatively visualize neuropsychological and behavioral function developing through visual, auditory and tactile experiences in the neonatal intensive care unit (NICU). After confirming a certain musical effect, supposedly in emotion as the participants' thermo-physiological alteration, we set a chronic recording system with thermal image sensors to detect body temperatures and behaviors simultaneously and a sound detector expected to translate socio-emotional signals. The inclusive analysis of these factors with oxygen saturation, heart rate and environmental sound, light and thermal indices showed the infants' biological rhythms and their modulation. Brain Diffusion Kurtosis Imaging analysis might suggest the group of earlier preterm births relatively aperiodic in their biological rhythms and higher suppression of water molecule diffusion in cerebrum.

Academic Significance and Societal Importance of the Research Achievements

ヒト心身の新生児期における発達を、恒常的に記録する生体および環境情報の包括分析により定量可視化する新規システムを試作開発した。その結果、療育環境における社会的ライフイベントや地球環境に則した音声・運動・生理の適応的リズム性やその変動のプロファイリングの有効性を、早産に係る臨床情報と脳分子機能評価を伴い相関解析により示し、ヒトの生涯発達IT開発における要件提示を試みた。精神疾患等の多様な疾病と生体リズム形成異常との関わりは先行知見多数に示唆され、本試作システムが捉えた胎児期の環境に影響を受けたリズム形成と変動の追跡記録と分析により、生涯発達支援IT、IoT開発の推進に寄与する可能性がある。

Research Products

• [Int'l Joint Research] Wisconsin University(米国)
• [Int'l Joint Research] University of Wisconsin/ZENEREI Institute(米国)
• [Int'l Joint Research] Almazov National Medical Research Centre/Ural Federal Universitye/Granov Russian Research Center(ロシア連邦)
• [Int'l Joint Research] Jiangsu University(中国)
• [Int'l Joint Research] Chungbuk National University/Kunsan National University(韓国)
• [Int'l Joint Research] レンヌ大学(フランス)
• [Int'l Joint Research] 江蘇大学/重慶理工大学/南西大学(中国)
• [Int'l Joint Research] 忠北大学/群山大学(韓国)
• [Int'l Joint Research] Ural Federal University(ロシア連邦)
• [Journal Article] Elderly Body Movement Alteration at 2nd Experience of Digital Art Installation with Cognitive and Motivation Scores (2020)
  • Author(s): Ting Tao, Ryota Sato, Yusuke Matsuda, Jumpei Takata, Fijun Kim, Yukio Daikubara, Koji Fujita, Kotaro Hanamoto, Fumio Kinoshita, Ricki Colman, Mamiko Koshiba*
  • Journal Title: J Volume: 3 Issue: 2 Pages: 138-150
  • DOI: 10.3390/j3020012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preterm infant vocal behavior and SpO2, pulse rate modulation in neonatal intensive care unit (2019)
  • Author(s): Ting Tao, Hayato Sakurai, Hiroko Kakei, Kayo Morita, Masakazu Honda, Yoshimasa Kamei, Hideo Yamanouchi, Tetsuya Kunikata, Mamiko Koshiba
  • Journal Title: Stress Brain and Behavior Volume: 1 Issue: 1 Pages: 36-42
  • DOI: 10.34417/sbb.1.1.36
  • Year and Date: 2019-01-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A cherry tree’s stress and recovery by inclusive intervention (2019)
  • Author(s): Yoshiaki Hayakawa, Mamiko Koshiba*
  • Journal Title: Stress Brain and Behavior Volume: 1 Issue: 1 Pages: 43-47
  • DOI: 10.34417/sbb.1.1.43
  • Year and Date: 2019-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Animal models of major depressive disorder and the implications for drug discovery and development. (2019)
  • Author(s): Konstantin Demin, (3名省略), Mamiko Koshiba, (13名省略), Allan V. KalueffAllan V. Kalueff
  • Journal Title: Expert Opinion on Drug Discovery Volume: 14(4) Issue: 4 Pages: 365-378
  • DOI: 10.1080/17460441.2019.1575360
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preterm infant vocal behavior and SpO2, pulse rate modulation in neonatal intensive care unit (2019)
  • Author(s): Ting Tao, Hayato Sakurai, Hiroko Kakei, Kayo Morita, Masakazu Honda, Yoshimasa Kamei, Hideo Yamanouchi, Tetsuya Kunikata, Mamiko Koshiba
  • Journal Title: Regional “Stress and Behavior” ISBS Conference Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A cherry tree’s stress and recovery by inclusive intervention. (2019)
  • Author(s): Yoshiaki Hayakawa, Mamiko Koshiba
  • Journal Title: Regional “Stress and Behavior” ISBS Conference Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal Recording Revealed Preterm Infants’ Acoustic Experiences Per Individual in Clinical Environments (2018)
  • Author(s): Ting Tao, Hayato Sakurai, Hiroko Kakei, Kayo Morita, Masakazu Honda, Zhongwei Jiang, Hideo Yamanouchi, Tetsuya Kunikata, Mamiko Koshiba
  • Journal Title: IJEIM Volume: accepted
  • Peer Reviewed
• [Presentation] 創発性・協働性を促す外遊び中の発話の園児間構造分析が示唆する発達 (2019)
  • Author(s): 金澤 亮、Kevin Jay Singh、鈴木 崚介、花 朱迪、陶 てい、横田 澄絵、久保田 健夫、仙田 満、谷口 新、大豆生田 啓友、小柴満美子*、渡辺 英則、張山 昌論
  • Organizer: こども環境学会2019年大会（九州）
• [Presentation] 自動画像処理に基づく遊び運動発達診断AI開発の試みと出張プレーパーク分析検証 (2019)
  • Author(s): Kevin J.S. Anajee Singh、花 朱迪、鈴木 崚介、金澤 亮、横田 澄絵、陶 てい、 大豆生田 啓友、久保田 健夫、渡辺 英則、張山 昌論、仙田 満、小柴満美子*
  • Organizer: こども環境学会2019年大会（九州）
• [Presentation] サル・モデルの行動定量分析が示す遊具の有無の社会性への影響 (2019)
  • Author(s): 依田真由子,小澤慎平、山内 秀雄、國方 徹也, 亀井良政, 久保田健夫, 小柴満美子
  • Organizer: こども環境学会2019年大会（九州）
• [Presentation] 胎児期新生児の音声分析で予測する昼・夜の環境温度感受性と酸素飽和度・脈拍数への影響 (2019)
  • Author(s): 陶 てい;、櫻井 隼人、筧 紘子、森田 佳代、本多 正和、山内 秀雄、國方 徹也、小柴 満美子*
  • Organizer: こども環境学会2019年大会（九州）
• [Presentation] 抗重力協調運動の発達を促す簡易組み立て式ヤグラ遊具の開発と出張プレーパーク検証 (2019)
  • Author(s): 花 朱迪、Kevin Jay Singh、鈴木 崚介、金澤 亮、陶 てい、小川佳代、小川勝巳、小川龍馬、小川龍飛、小川璃織、中島 寿子、川﨑 徳子、高田 和宜、横田 澄絵、仙田 満、小澤紀美子、大豆生田 啓友、久保田 健夫、渡辺 英則、張山 昌論、小柴満美子*
  • Organizer: こども環境学会2019年大会（九州）
• [Presentation] 新生児集中治療室保育器の包括的恒常計測IT化の試み (2019)
  • Author(s): 陶 てい;、櫻井隼人、筧紘子、森田佳代、本多正和、山内秀雄、亀井良政、國方徹也、小柴満美子
  • Organizer: 第64回日本新生児成育医学会・学術集会
• [Presentation] 非鎮静下のNICU入院児のDiffusion Kurtosis Imaging (DKI)による早期脳神経発達評価 (2019)
  • Author(s): 櫻井隼人、花朱迪
  • Organizer: 第64回日本新生児成育医学会・学術集会
• [Presentation] 母乳育児障害と介入法検証のための霊長類コモン・マーモセット・モデルの確立 (2019)
  • Author(s): 依田真由子、國方徹也、亀井良政、小柴満美子
  • Organizer: 第64回日本新生児成育医学会・学術集会
• [Presentation] 小児の共創機能発達の定量可視化技術開発 (2019)
  • Author(s): ヌールダニアビンティモハマドアスリ、小柴満美子
  • Organizer: 日本機械学会 中国四国支部第58回
• [Presentation] 精神の生涯発達を主題とした幼児教育支援技術の開発と検証 (2019)
  • Author(s): 鈴木崚介，小柴満美子，花朱迪，Kevin Jay Singh, 金澤亮，陶テイ，中島寿子，川﨑徳子，高田和宜，大木順司，蒋飛，門脇弘子，中島翔太，秋田 知芳，堀田 一敬、久保田健夫，横田澄絵、張山昌論、渡辺英則、仙田満，小澤紀美子、天野 秀昭
  • Organizer: 日本機械学会中国四国学生会第49回学生員卒業研究発表講演会
• [Presentation] Preterm infant vocal behavior and SpO2 modulation under optical frequency condition in neonatal intensive care unit. (2018)
  • Author(s): Ting Tao, Hayato Sakurai, Hiroko Kakei, Kayo Morita, Masakazu Honda, Yoshimasa Kamei, Hideo Yamanouchi, Tetsuya Kunikata, Mamiko Koshiba
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research
• [Presentation] Mechanism and management of status epilepticus. (2018)
  • Author(s): Hideo Yamanouchi
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research / Invited
• [Presentation] Early childhood learning and development in play: ube city one-day playpark report (2018)
  • Author(s): Mamiko Koshiba
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research / Invited
• [Presentation] Indoor and outdoor positioning systems for behavior analysis of children. (2018)
  • Author(s): Masanori Hariyama, Naoto Miyamoto, Yasuhiro Kobayashi, Mamiko Koshiba, Taiki Matunaga, Ryuki Kai, Hidenori Watanabe, Sachiko Ito, Takeo Kubota, Mitsuru Senda, Shin Taniguchi
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research / Invited
• [Presentation] Familiar or unfamiliar infant-social distance during play visualized by gps, confirmed by video. (2018)
  • Author(s): Ryuki Kai, Taiki Matunaga, Sumie Yokota, Ryosuke Suzuki, Kevin Jay Singh, Ryo Kanazawa, Masanori Hariyama, Naoto Miyamoto, Yoshiro Kobayashi, Hidenori Watanabe, Sachiko Ito, Takeo Kubota, Mitsuru Senda, Shin Taniguchi, Mamiko Koshiba
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research
• [Presentation] A male common marmoset grief at the partner's death. (2018)
  • Author(s): Mayuko Yoda, Hua Zhudii, Ting Tao, Yoshimasa Kamei, Hideo Yamanouchi, Mamiko Koshiba
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research
• [Presentation] A cherry tree’s stress and recovery by inclusive intervention. (2018)
  • Author(s): Yoshiaki Hayakawa, Mamiko Koshiba
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research / Invited
• [Presentation] Shrine interactive instalation vitalized children active behviors and positive emotion in the local community. (2018)
  • Author(s): Hua Zhudii, Ryota Sato, Yuki Horikawa, Mitsuyuki Kumagai, Yoshiaki Hayakawa, Junko Kaneko, Yuji Marumo, Mamiko Koshiba
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research
• [Presentation] Elderly psychological influences in digital-interactive space training through human sound or motion sensing. (2018)
  • Author(s): Kohji Fujita K, Ryota Sato, Junpei Takata, Yusuke Matsuda, Ting Tao, FUmio Kinoshita, Mamiko Koshiba
  • Organizer: 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference
  • Int'l Joint Research
• [Presentation] Early life influences on social-emotional development in common marmosets (2018)
  • Author(s): Mamiko Koshiba, Genta karino, Aya Senoo, Tetsuya Kunikata, Yoshimasa Kamei, Hideo Yamanouch
  • Organizer: International Primatological Society Congresses 2018 Nairobi, Kenya
  • Int'l Joint Research / Invited
• [Presentation] シンポジウム「あそび学ぶ」 (2018)
  • Author(s): 小柴満美子
  • Organizer: こども環境学会2018年埼玉大会
  • Invited
• [Presentation] 幼児教育IoT開発に向けた、あそび中の社会性計測 (2018)
  • Author(s): 甲斐龍生、藤田晃司、花本晃太朗、佐藤瞭太、陶テイ、張山昌論、宮本直人、渡辺英則、伊藤幸子、嶋崎さなえ、大豆生田啓友、久保田健夫、谷口新、仙田満、小柴満美子
  • Organizer: こども環境学会2018年埼玉大会
• [Presentation] 拡張現実ARと現実が融合する複合現実MRが齎す“あそびの学び” -光の庭- Play Ground - (2018)
  • Author(s): 佐藤瞭太、高田淳平、吉川燿敬、中野智広、小柴満美子
  • Organizer: こども環境学会2018年埼玉大会
• [Presentation] 早産児の体表温と運動の恒常的計測システムの開発 (2018)
  • Author(s): 中司翔太、陶テイ、櫻井隼人、筧紘子、森田佳代、本多正和、江鐘偉、山内秀雄、國方徹也、小柴満美子
  • Organizer: こども環境学会2018年埼玉大会
• [Presentation] 幼児視点での社会性計測技術の開発 (2018)
  • Author(s): 藤田晃司、甲斐龍生、花本晃太朗、佐藤瞭太、陶テイ 、大豆生田啓友、久保田健夫、谷口新、仙田満、小柴満美子
  • Organizer: こども環境学会2018年埼玉大会
• [Presentation] あそび学ぶ状態推移計測：音声・環境音解析 (2018)
  • Author(s): 陶テイ、伊藤幸子、嶋崎さなえ、渡辺英則、谷口 新、仙田満、大豆生田 啓友、久保田 健夫、張山 昌論、小柴満美子
  • Organizer: こども環境学会2018年埼玉大会
• [Presentation] Play-Learning (2018)
  • Author(s): Mamiko Koshiba
  • Organizer: Innovative Research and Education of Asia 2018 Jiangsu
  • Int'l Joint Research / Invited
• [Presentation] 情育の視点から-自己境界を越えた「外」の役わり- (2017)
  • Author(s): 小柴満美子
  • Organizer: こども環境学会北海道大会
  • Invited
• [Presentation] ビッグデータ解析が示した音の環境やライフイベントが新生児の発声行動の発達に与える影響 (2017)
  • Author(s): 陶テイ,櫻井隼人,筧紘子,森田佳代,本多正和,江鐘偉,山内秀雄,國方徹也,*小柴満美子
  • Organizer: こども環境学会北海道大会
• [Presentation] 早産児の体表温と運動の恒常的計測システムの開発 (2017)
  • Author(s): 中司翔太、陶テイ、櫻井隼人, 筧紘子, 森田佳代, 本多正和, 江 鐘偉, 山内秀雄, 國方徹也、, *小柴 満美子
  • Organizer: こども環境学会北海道大会
• [Presentation] Neuro-Tech-Environmentology for child mental development. (2017)
  • Author(s): Mamiko Koshiba, Masanori Hariyama, Hidenori Watanabe, Sachiko Ito, Sanae Shimazaki, Tao Ting, Naoto Miyamoto, Takeo Kubota, Shin Taniguchi, Mitsuru Senda, Masanori Shukuya
  • Organizer: The 7th Regional “Stress and Behavior” ISBS Conference, Yokohama, Japan
  • Int'l Joint Research / Invited
• [Presentation] Longitudinal Recording Revealed Preterm Infants’ Circadian Vocal Behaviors Influenced by Care Events (2017)
  • Author(s): Tao Ting, Hayato Sakurai, Hiroko Kakei, Kayo Morita, Masakazu Honda, Hideo Yamanouchi, Tetsuya Kunikata,Mamiko Koshiba,
  • Organizer: The 7th Regional “Stress and Behavior” ISBS Conference, Yokohama, Japan
  • Int'l Joint Research / Invited
• [Presentation] 高精度GPSの情育環境技術応用 (2017)
  • Author(s): 張山昌論,宮本直人,渡辺英則, 伊藤幸子, 嶋崎さなえ,陶テイ,宮本雄太,久保田健夫,谷口新,仙田満,*小柴満美子
  • Organizer: こども環境学会分科会、情育環境学研究集会
  • Invited
• [Presentation] 共有する建築環境空間は情育を導くユリカゴ (2017)
  • Author(s): 佐藤瞭太, 張山昌論,宮本直人,渡辺英則, 伊藤幸子, 嶋崎さなえ,陶テイ,宮本雄太,久保田健夫,谷口新,仙田満, *小柴満美子
  • Organizer: こども環境学会分科会,情育環境学研究集会
  • Invited
• [Presentation] 環境音分析に基づく情育の生理応答 (2017)
  • Author(s): 陶テイ,張山昌論,宮本直人,渡辺英則, 伊藤幸子, 嶋崎さなえ,宮本雄太,久保田健夫,谷口新,仙田満, *小柴満美子
  • Organizer: こども環境学会分科会, 情育環境学研究集会
  • Invited
• [Presentation] Development of a Constant Measurement System of Premature Infant’s Body Surface Temperatures and Activities (2017)
  • Author(s): Shota Nakatsukasa, Tao Ting, Hayato Sakurai, Hiroko Kakei, Kayo Morita, Masakazu Honda, Hideo Yamanouchi, Tetsuya Kunikata, Mamiko Koshiba
  • Organizer: ICIARE2017, Yamaguchi, Japan
  • Int'l Joint Research
• [Presentation] Garden of the Light - Play Ground- (2017)
  • Author(s): Ryota Sato,Junpei Takata, Terutaka Yoshikawa, Tomohiro Nakano, *Mamiko Koshiba
  • Organizer: ICIARE2017, Yamaguchi, Japan
  • Int'l Joint Research
• [Presentation] Illumination-installation for Elderly Brains’ Activation (2017)
  • Author(s): Koji Fujita,Ryuki Kai, Ryota Sato, Junpei Takata, *Mamiko Koshiba
  • Organizer: ICIARE2017, Yamaguchi, Japan
  • Int'l Joint Research
• [Book] 周産期医学2019年49巻増刊号周産期相談310お母さんへの回答マニュアル第３版「耳の後ろにぐりぐりがありますが、これは何ですか？」 (2019)
  • Author(s): 國方徹也
  • Total Pages: 736
  • Publisher: 東京医学社
• [Book] 周産期医学2019年49巻増刊号周産期相談310お母さんへの回答マニュアル第３版「鼻づまりで苦しそうにみえるのですが、どうすればよいですか？」 (2019)
  • Author(s): 國方徹也
  • Total Pages: 736
  • Publisher: 東京医学社
• [Book] 周産期医学2019年49巻増刊号周産期相談310お母さんへの回答マニュアル第３版「しょっちゅう鼻がぐずぐずして、くしゃみも多いです。風邪ですか？」 (2019)
  • Author(s): 國方徹也
  • Total Pages: 736
  • Publisher: 東京医学社
• [Remarks] いえにいる こどもたちへ オンライン・プレーパーク つくりんたっち
  • URL: http://www.children-env.org/magazine/blogs/blog_entries/index/23?page_id=4
• [Patent(Industrial Property Rights)] 行動分析システム (2018)
  • Inventor(s): 小柴満美子,佐藤瞭太,甲斐龍生,花本晃太朗,藤田晃司,陶テイ
  • Industrial Property Rights Holder: 山口大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Patent(Industrial Property Rights)] プロジェクションシステム (2018)
  • Inventor(s): 小柴満美子、佐藤瞭太、高田淳平、吉川燿敬、中野智広
  • Industrial Property Rights Holder: 山口大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
• [Funded Workshop] 15th International Regional (Asia) ISBS Neuroscience and Biological Psychiatry “Stress and Behavior” Conference (2018)
• [Funded Workshop] 国際行動ストレス学会横浜大会 (2017)