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Origin of blood rheology: Toward comprehensive understanding of single-, two- and many-body mechanics

Research Project

Project/Area Number 17K18759
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Condensed matter physics and related fields
Research InstitutionOsaka University

Principal Investigator

Ito Hiroaki  大阪大学, 工学研究科, 特別研究員(PD) (10783186)

Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords赤血球 / 細胞力学 / ヘモレオロジー / マイクロ流体工学 / パターン形成 / 多体相互作用 / 物性実験
Outline of Final Research Achievements

Blood is a fluid in which many soft blood cells are dispersed. Fluidity of such solutions is largely different from that of simple viscous fluid. In this study, we performed microfluidic experiments with a microchannel, whose diameter is similar to that of microvasculature, to investigate the spatial pattern of red blood cells (RBCs) in blood flow. In the consequence, we found that stirring of red blood cells (RBCs) by the flow formed around other RBCs becomes more vigorous at the physiological RBC density (called hematocrit, which indicates the amount of RBCs in blood). Moreover, the specific spatial structure of velocity correlation is observed. At higher density, the spatial structure disappears due to the dense packing.

Academic Significance and Societal Importance of the Research Achievements

血液はたくさんの柔らかい血球細胞が分散した溶液であり。このような溶液がどのように流れるのか、どのようにサラサラ・ドロドロ(粘性)の性質が現れるのかを知ることは、医療の進展にもつながる基礎科学の目標の一つである。本研究結果では、赤血球の密度に応じて流れ方が質的に異なり、特に生理濃度以上の赤血球密度では流体よりも粒子としての性質が流れに強く影響することがわかった。ここで得られた成果は、貧血や多血症、脱水症状などの異常時における血液の流れ方の理解に向けた大きな手がかりとなる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (30 results)

All 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (22 results) (of which Int'l Joint Research: 11 results) Remarks (3 results)

  • [Int'l Joint Research] National Chiao Tung University(その他の国・地域(台湾))

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Deformation of a red blood cell in a narrow rectangular microchannel.2019

    • Author(s)
      Naoki Takeishi, Hiroaki Ito, Makoto Kaneko, Shigeo Wada.
    • Journal Title

      Micromachines

      Volume: 10 Issue: 3 Pages: 199-199

    • DOI

      10.3390/mi10030199

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LED-CT Scan for pH Distribution on a Cross-Section of Cell Culture Medium2018

    • Author(s)
      Nobuya Higashino, Toshio Takayama, Hiroaki Ito, Mitsuhiro Horade, Yasutaka Yamaguchi, Chia-Hung Dylan Tsai, and Makoto Kaneko
    • Journal Title

      Sensors

      Volume: 18(1) Issue: 1 Pages: 1-10

    • DOI

      10.3390/s18010191

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] On-chip density mixer enhanced by air chamber2018

    • Author(s)
      Toshio Takayama, Hiroki Miyashiro, Chia-Hung Dylan Tsai, Hiroaki Ito, Makoto Kaneko
    • Journal Title

      Biomicrofluidics

      Volume: 12 Issue: 4 Pages: 044108-044108

    • DOI

      10.1063/1.5033482

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 自動細胞品質評価のためのOn-chip対象物位置制御システムの最適化2018

    • Author(s)
      伊藤弘明, 小宮拓也, 洞出光洋, 高山俊男, 金子真
    • Journal Title

      再生医療とリハビリテーション

      Volume: 1 Pages: 1-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] On-chip dynamic mechanical measurement2019

    • Author(s)
      Atsushi Kirimoto, Hiroaki Ito, Mitsuhiro Horade, Toshio Takayama, Misato Chimura, Tomohito Ohtani, Yasushi Sakata, Makoto Kaneko
    • Organizer
      The 32nd International Conference on IEEE Micro Electro Mechanical System (MEMS 2019, Seoul, Korea)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How to measure cellular shear modulus inside a chip: Detailed correspondence to the fluid-structure coupling analysis2019

    • Author(s)
      Hiroaki Ito, Naoki Takeishi, Atsushi Kirimoto, Misato Chimura, Tomohito Ohtani, Yasushi Sakata, Mitsuhiro Horade, Toshio Takayama, Makoto Kaneko
    • Organizer
      The 32nd International Conference on IEEE Micro Electro Mechanical System (MEMS 2019, Seoul, Korea)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DC電場に誘起される荷電脂質ベシクルの相分離と細孔形成2019

    • Author(s)
      伊藤弘明、樋口祐次、下川直史
    • Organizer
      日本物理学会第73回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Integration of fluctuation spectroscopy into a microfluidic platform for novel cellular viscoelastic measurement2018

    • Author(s)
      Hiroaki Ito, Chia-Hung Dylan Tsai, Makoto Kaneko
    • Organizer
      The 31st International Conference on IEEE Micro Electro Mechanical System (MEMS 2018, Berfast, UK)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of both viscous and elastic constants of a red blood cell in a microchannel2018

    • Author(s)
      Atsushi Kirimoto, Hiroaki Ito, Chia-Hung Dylan Tsai, Makoto Kaneko
    • Organizer
      The 31st International Conference on IEEE Micro Electro Mechanical System (MEMS 2018, Berfast, UK)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of micromanipulator with semiconductor strain gauge that can be used in solution for characteristics measurement2018

    • Author(s)
      Mitsuhiro Horade, Osamu Tabata, Hiroaki Ito, Toshio Takayama, Dylan Tsai, Makoto Kaneko
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2018, Kaohsiung, Taiwan)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Automatically optimized on-chip feedback manipulation toward clinical use2018

    • Author(s)
      Hiroaki Ito, Takuya Komiya, Mitsuhiro Horade, Toshio Takayama, Makoto Kaneko
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2018, Kaohsiung, Taiwan)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deep learning assisted analysis of multiple individual red blood cells in blood flow2018

    • Author(s)
      Takayuki Akai, Hiroaki Ito, Makoto Kaneko
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS2018, Kaohsiung, Taiwan)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coarse-grained molecular dynamics simulation of phase separation and morphological dynamics of a charged lipid vesicle2018

    • Author(s)
      Hiroaki Ito, Yuji Higuchi, Naofumi Shimokawa
    • Organizer
      Soft Matter Physics: from the perspective of the essential heterogeneity (SMPH2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] On-Chip Measurement of Red Blood Cell Mechanics2018

    • Author(s)
      Hiroaki Ito
    • Organizer
      2018 International Workshop on Bio/Medical/Cognitive Science -Current and Future Direction-
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体界面の粘弾性:膜ゆらぎと大変形の相関2018

    • Author(s)
      伊藤弘明、桐本淳司、C. H. Dylan Tsai、金子真
    • Organizer
      日本物理学会第72回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] オンチップマニピュレーションで抽出する赤血球の時変粘弾性2018

    • Author(s)
      伊藤弘明、北村颯太、柳原大貴、洞出光洋、高山俊男、金子真
    • Organizer
      ロボティクス・メカトロニクス講演会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血液の2次元流れにおける血球密度依存性2018

    • Author(s)
      赤井孝行、伊藤弘明、金子真
    • Organizer
      ロボティクス・メカトロニクス講演会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロ流体中における細胞の変形と応力の関係2018

    • Author(s)
      桐本淳司、伊藤弘明、金子真
    • Organizer
      ロボティクス・メカトロニクス講演会2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞の狭窄変形における負荷時間依存粘弾性2018

    • Author(s)
      伊藤弘明、桐本淳司、武石直樹、金子真
    • Organizer
      日本物理学会2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Loading-time dependence of cellular viscoelasticity under shear and squeezed deformation2018

    • Author(s)
      伊藤弘明、桐本淳司、武石直樹、金子真
    • Organizer
      日本生物物理学会第56回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 非平衡界面現象の観点からみる生細胞の力学応答2018

    • Author(s)
      伊藤弘明
    • Organizer
      第69回コロイドおよび界面化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 荷電脂質ベシクルの相分離と形態変化の粗視化動力学シミュレーション2018

    • Author(s)
      伊藤弘明、樋口祐次、下川直史
    • Organizer
      第8回ソフトマター研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 短時間微小変形における赤血球粘弾性計測2018

    • Author(s)
      桐本淳司、伊藤弘明、金子真
    • Organizer
      第19回計測自動制御学会システムインテグレーション部門講演会(SI2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血液2次元流れにおける赤血球機械特性の効果2018

    • Author(s)
      赤井孝行、伊藤弘明、金子真
    • Organizer
      第19回計測自動制御学会システムインテグレーション部門講演会(SI2018)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Integration of fluctuation spectroscopy into a microfluidic platform for novel cellular viscoelastic measurement2018

    • Author(s)
      Hiroaki Ito, Chia-Hung Dylan Tsai, Makoto Kaneko
    • Organizer
      The 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018, Belfast, UK)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Measurement of both viscous and elastic constants of a red blood cell in a microchannel2018

    • Author(s)
      Atsushi Kirimoto, Hiroaki Ito, Chia-Hung Dylan Tsai, Makoto Kaneko
    • Organizer
      The 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS2018, Belfast, UK)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] Hiroaki Ito

    • URL

      http://nonlinear.s.chiba-u.jp/~ito/

    • Related Report
      2018 Annual Research Report
  • [Remarks] ResearchGate

    • URL

      https://www.researchgate.net/profile/Hiroaki_Ito3

    • Related Report
      2018 Annual Research Report
  • [Remarks] Hiroaki Ito

    • URL

      http://www-hh.mech.eng.osaka-u.ac.jp/~ito/

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2022-08-19  

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