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In-line optical detection of single nanoparticle

Research Project

Project/Area Number 17K18845
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Fluid engineering, Thermal engineering, and related fields
Research InstitutionTokyo University of Science

Principal Investigator

Motosuke Masahiro  東京理科大学, 工学部機械工学科, 准教授 (80434033)

Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsナノ粒子 / マイクロデバイス / 光検出 / 光計測 / マイクロ・ナノデバイス
Outline of Final Research Achievements

This study aims to develop a highly sensitive measurement method for single nanoparticles in liquid. Scattered light from a particle by a focused laser irradiation can be detected by lock-in heterodyne interferometric technique. Finally, we succeed in the detection of the scattered light signal from a 20nm-nanoparticle flowing in a microfluidic device.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したナノ粒子計測技術は,これまでは液中に多数の粒子が必要であったナノ粒子計測のキャラクタリゼーションをより希薄粒子系に対して実現できるようにするものであり,新規ナノ物質の定量評価を大きく推進することが期待される.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (36 results)

All 2019 2018 2017 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (32 results) (of which Int'l Joint Research: 19 results,  Invited: 11 results) Remarks (2 results)

  • [Journal Article] Three-dimensional flow velocity and wall shear stress distribution measurement on a micropillar-arrayed surface using astigmatism PTV to understand the influence of microstructures on the flow field2018

    • Author(s)
      Yoshiyasu Ichikawa, Ken Yamamoto, Masahiro Motosuke
    • Journal Title

      Microfluidics and Nanofluidics

      Volume: 22 Issue: 7 Pages: 73-73

    • DOI

      10.1007/s10404-018-2095-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Near-hydrophobic-surface flow measurement by micro-3D PTV for evaluation of drag reduction2017

    • Author(s)
      Y. Ichikawa, K. Yamamoto, M. Yamamoto, M. Motosuke
    • Journal Title

      Physics of Fluids

      Volume: 29 Issue: 9 Pages: 092005-092005

    • DOI

      10.1063/1.5001345

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] All-PDMS cytometer chip with embedded fiber waveguide and optimized 3D hydrodynamics focusing2019

    • Author(s)
      Masahiro Motosuke, Reiya Ono, Kosuke, Shigeta, Ken Yamamoto
    • Organizer
      The 32nd IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Photoactivation of interfacial tension gradient for advanced droplet manipulation2018

    • Author(s)
      Masahiro Motosuke
    • Organizer
      EMN Meeting on Droplet 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Adhesion-free separation of particles/cells using three dimensional negative dielectrophoretic force2018

    • Author(s)
      Mio Mizoguchi, Ken Yamamoto, Babita Shashni, Shin Aoki, Masahiro Motosuke
    • Organizer
      9th Asia-Pacific Conference of Transducers and Micro-Nano Technology (APCOT 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improved nanoparticle concentrator chip using AC electroosmosis2018

    • Author(s)
      Kensuke Fujita, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      9th Asia-Pacific Conference of Transducers and Micro-Nano Technology (APCOT 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of fluid flow-micropillar array interaction on the wall shear stress in a microchannel2018

    • Author(s)
      Yoshiyasu Ichikawa, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      18th International Symposium on Flow Visualization (ISFV 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Controlled interfacial flow: principle and its potential future2018

    • Author(s)
      Masahiro Motosuke
    • Organizer
      Water on Materials Surface (WMS) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Improved electrothermal flow manipulation for rapid and sensitive detection of analytes2018

    • Author(s)
      Tomoka Higaki, Motoki Hino, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      Water on Materials Surface (WMS) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bubble-based dilutor and slit-type RBC agglutination detector for an integrated microfluidic blood typing device using whole blood2018

    • Author(s)
      Ryosuke Sakurai, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      Water on Materials Surface (WMS) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of droplet activation method by photothermal interfacial flow2018

    • Author(s)
      Masakazu Muto, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      Water on Materials Surface (WMS) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single detection of 20-nm particle by heterodyne interferometric microfluidic cytometry2018

    • Author(s)
      Masumi Serita, Daiki Sakai, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      22nd International Conference on Miniaturized Systems for Chemistry and Life Science (micro-TAS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimized electrode array for enhanced protein biding by electrothermal flow modulation2018

    • Author(s)
      Tomoka Higaki, Motoki Hino, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      22nd International Conference on Miniaturized Systems for Chemistry and Life Science (micro-TAS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Whole-bood-based microfluidic blood typing chip with precise dilution and sensitive agglutination level detection2018

    • Author(s)
      Ryosuke Sakurai, Ken Yamamoto, Masahiro Motosuke
    • Organizer
      22nd International Conference on Miniaturized Systems for Chemistry and Life Science (micro-TAS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Concentration-adjustable superdilutor chip2018

    • Author(s)
      Ken Yamamoto, Ryosuke Sakurai, Masahiro Motosuke
    • Organizer
      22nd International Conference on Miniaturized Systems for Chemistry and Life Science (micro-TAS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 固液界面近傍における液体成分の識別および液体温度計測2018

    • Author(s)
      元祐 昌廣, 武田 咲希絵, 執行 悠太, 山本 憲
    • Organizer
      第55回日本伝熱シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 蛍光異方性による温度測定の高空間分解能化へ向けた検討2018

    • Author(s)
      武田 咲希絵, 執行 悠太, 山本 憲, 元祐 昌廣
    • Organizer
      第55回日本伝熱シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 光熱効果を用いた非接触液滴ソーティング2018

    • Author(s)
      武藤 真和, 山本 憲, 山本 誠, 元祐 昌廣
    • Organizer
      第55回日本伝熱シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] マイクロ流路内ピラーアレイ周りの3次元流動計測2018

    • Author(s)
      市川 賀康, 山本 憲, 元祐 昌廣
    • Organizer
      第55回日本伝熱シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 微小界面流の制御とその応用2018

    • Author(s)
      元祐 昌廣
    • Organizer
      日本学術振興会 水の先進理工学第183委員会 第44回研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 単一ナノ粒子の光干渉検出2018

    • Author(s)
      芹田 真澄, 酒井 大輝, 山本 憲, 元祐 昌廣
    • Organizer
      熱工学コンファレンス
    • Related Report
      2018 Annual Research Report
  • [Presentation] ジュール加熱を用いた流動制御による界面反応促進2018

    • Author(s)
      檜垣 知加, 日野 元貴, 山本 憲, 元祐 昌廣
    • Organizer
      熱工学コンファレンス
    • Related Report
      2018 Annual Research Report
  • [Presentation] 数値シミュレーションと実験を駆使した最先端熱流体システム開発2018

    • Author(s)
      元祐 昌廣
    • Organizer
      COMSOLカンファレンス2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Interfacial flow modulation in microfluidic platform2018

    • Author(s)
      M. Motosuke
    • Organizer
      9th Workshop of Chemical and Biological Micro Laboratory Technology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Microfluidic approach toward highly efficient biomedical interface2018

    • Author(s)
      M. Motosuke
    • Organizer
      3rd International Biomedical Interface Symposium (IBMI2018)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Fluidic-force-based nanoparticle concentrator chip2017

    • Author(s)
      K. Fujita, K. Yamamoto, M. Motosuke
    • Organizer
      21st International Conference on Miniaturized Systems for Chemistry and Life Science (micro-TAS)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simple way of optical manipulation of particles/cells in microfluidic systems2017

    • Author(s)
      M. Motosuke
    • Organizer
      8th International Conference and Exhibition on Lasers, Optics & Photonics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Microchannel slip flow structure near superhydrophobic surface2017

    • Author(s)
      Y. Ichikawa, K. Yamamoto and M. Motosuke
    • Organizer
      70th Annual Meeting of the APS Division of Fluid Dynamics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Flexible microfluidic control for highly functionalized LOAC platform2017

    • Author(s)
      M. Motosuke
    • Organizer
      Lab-on-a-Chip & Microfluidics, Point-of-Care Diagnostics & Global Health Asia 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] マイクロ流路内コンポジット壁面近傍の3次元流動計測2017

    • Author(s)
      市川 賀康, 山本 憲, 山本 誠, 元祐 昌廣
    • Organizer
      第54回日本伝熱シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 高感度な単一ナノ粒子の光学的検出手法の開発2017

    • Author(s)
      酒井 大輝, 山本 憲, 元祐 昌廣
    • Organizer
      第54回日本伝熱シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 微小スケールにおける界面流動の制御2017

    • Author(s)
      元祐 昌廣
    • Organizer
      日本機械学会2017年度年次大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 光熱バルブによる液滴の軌道制御2017

    • Author(s)
      武藤 真和, 山本 憲, 山本 誠, 元祐 昌廣
    • Organizer
      日本流体力学会年会2017
    • Related Report
      2017 Research-status Report
  • [Presentation] マイクロ流体制御と計測2017

    • Author(s)
      元祐 昌廣
    • Organizer
      第8回マイクロ・ナノ工学シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Remarks] 研究室ウェブサイト

    • URL

      http://www.rs.tus.ac.jp/motlab/jp/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究室webサイト

    • URL

      http://www.rs.tus.ac.jp/motlab/jp/index.html

    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2020-03-30  

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