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Preparation processes of nano-DDS careers using supercritical carbon dioxide

Research Project

Project/Area Number 17K19003
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Chemical engineering and related fields
Research InstitutionTohoku University

Principal Investigator

INOMATA HIROSHI  東北大学, 工学研究科, 教授 (10168479)

Co-Investigator(Kenkyū-buntansha) 宇敷 育男  広島大学, 工学研究科, 助教 (30734850)
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords超臨界 / DDS / 吸着 / 徐放剤 / メソポーラスシリカ / 薬剤 / ドラッグデリバリーシステム / 含浸 / 多孔材料
Outline of Final Research Achievements

Preparation processes of nano-DDS (drug delivery system) careers using supercritical carbon dioxide (scCO2) method were studied. MCM-41 mesoporous silica and ibuprofen were selected as the model DDS career and model drug, respectively. The experimental results showed that the scCO2 method could achieve a larger amount of deposited drug onto the mesoporous silica material in comparison with the conventional liquid solvent methods. The amount of deposited drug onto MCM-41 depended strongly on the pressure conditions in the scCO2 method, which could be rationalized by the effects of the solubility of ibuprofen and adsorption equilibria of the drug on MCM-41 in scCO2.

Academic Significance and Societal Importance of the Research Achievements

近年新薬候補の高分子量化に伴い血液への溶解性及びバイオアベイラビリティが低下するという問題が顕在化している.これに対して薬剤微粒化に伴う比表面積増加を利用したアプローチが検討されているが,数十nm単位までの粒径制御が限界となっている.本研究は、粒径制御は担体のメソポーラスシリカにて行い,そのミクロ孔への薬剤微粒子の含浸を超臨界法で行うことが可能であることを実証した.これは,難水溶性薬剤の大幅な適用範囲拡大が期待できるという点で大きな意義を有すると考える.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2018

All Presentation (2 results)

  • [Presentation] 超臨界CO2を用いたメソポーラスシリカへの薬剤含浸プロセスの検討2018

    • Author(s)
      野口 純矢,宇敷 育男,木原 伸一,滝嶌 繁樹,猪股 宏
    • Organizer
      化学工学会 第84年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 超臨界法によるメソポーラスシリカへの薬剤含浸プロセスの検討2018

    • Author(s)
      野口 純矢,宇敷 育男,木原 伸一,滝嶌 繁樹,猪股 宏
    • Organizer
      第20回化学工学会学生発表会(東広島大会)
    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2020-03-30  

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