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Dielectrophoresis for single-molecule identification by tunneling current measurements

Research Project

Project/Area Number 17K19033
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Nano/Micro science and related fields
Research InstitutionOsaka University

Principal Investigator

Tsutsui Makusu  大阪大学, 産業科学研究所, 准教授 (50546596)

Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywordsトンネル電流 / 1分子 / MEMS / 単分子 / シークエンサー / 分子エレクトロニクス / 誘電泳動 / トンネル / マイクロ・ナノデバイス / ナノコンタクト / 量子閉じ込め / 界面 / トンネル現象 / バイオテクノロジー / バイオ関連機器
Outline of Final Research Achievements

We developed a novel insulator-coated nanoelectrodes and used them for single-molecule conductance measurements under AC bias voltage. Evaluating the influence of the AC-fieled on the geometrical variations of the molecular junctions through the width of conductance peaks in coductance histograms, we observed narrowed distributions for relatively long pai-conjugated moleculars under AC voltage of relatively large amplitude. The results serve to validate the effectiveness of AC field-induced dielectrophoretic forces to control the moelcular conformations and/or electrode-molecule contact structures.

Academic Significance and Societal Importance of the Research Achievements

本成果によって、トンネル電流法による1塩基分子識別の精度向上が見込める。特に、本手法はナノ電極間にAC電圧を印加するだけで済むため、従来技術に容易に応用することが可能なものである。今後、当該手法が1分子測定に広く応用されることで、1分子シークエンサーや分子エレクトロニクスの実現に大きく貢献できると期待される。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Measuring Single-Molecule Conductance at An Ultra-Low Molecular Concentration in Vacuum2018

    • Author(s)
      Liu Bo、Tsutsui Makusu、Taniguchi Masateru
    • Journal Title

      Micromachines

      Volume: 9 Issue: 6 Pages: 282-282

    • DOI

      10.3390/mi9060282

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detecting Single-Nucleotides by Tunneling Current Measurements at Sub-MHz Temporal Resolution2017

    • Author(s)
      Takanori Morikawa, Kazumichi Yokota, Sachie Tanimoto, Makusu Tsutsui, Masateru Taniguchi
    • Journal Title

      Sensors

      Volume: 17 Issue: 4 Pages: 885-885

    • DOI

      10.3390/s17040885

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Single Molecule Conductance Measurements under High Temperature in Vacuum2019

    • Author(s)
      Bo Liu, Makusu Tsutsui, masateru Taniguchi
    • Organizer
      応用物理学会春季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Detection of Single-Molecule at an Ultra-Low Molecular Concentration in Vacuum2018

    • Author(s)
      Bo Liu, Makusu Tsutsui, Masateru Taniguchi
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report

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Published: 2017-07-21   Modified: 2020-03-30  

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