Ionization assist ability of magnetic nanoparticles and application for mass spectrometric imaging

• Project/Area Number: 17K19073
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Applied physics and engineering and related fields
• Research Institution: Yokohama National University
• Principal Investigator: Ichiyanagi Yuko 横浜国立大学, 大学院工学研究院, 教授 (90240762)
• Project Period (FY): 2017-06-30 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 磁性体 / イオン化支援能 / 質量分析 / 微粒子 / 遷移金属化合物 / イオン化 / 磁気微粒子 / イオン化支援機能 / ナノ微粒子 / 遷移金属酸化物

Outline of Final Research Achievements

Magnetic nanoparticles were prepared by original wet method. The particles were farther developed as new matrix by modification for MALDI-TOF-MS system. We have detected small molecular analytes such as colchicin and aspirin using our developed functional nanoparticles. These analytes were normally hard to detect because of their very small molecules. We have successfully detectied glycolipids associated with pancreatic cancer. Materials concerning with lever disease were also detected.

Academic Significance and Societal Importance of the Research Achievements

すい臓がんなどは発見が非常に難しい上に進行が早く、原因や発症する傾向さえもわかっていない難治性癌として知られている。原因解明への新たな分析手法を開発することが望まれる。
本研究により磁気ナノ微粒子を用いて、従来では検出不可能であった質量領域におけるイオン化を実現させるとともに、質量分析スペクトルの高分解能化をはかる。
磁気ナノ微粒子の物性や、イオン化のメカニズムなどを究明する物理工学の基礎研究を基盤とし、これまでほとんど接点の無かった病理研究分野へ新たなアプローチを提案する。

Research Products

• [Int'l Joint Research] Argonne National Laboratory(米国)
• [Int'l Joint Research] Oviedo University(スペイン)
• [Int'l Joint Research] オビエド大学(スペイン)
• [Journal Article] Characterization and theranostics application of pluralistic ferrite nanoparticles (2017)
  • Author(s): Yuko Ichiyanagi
  • Journal Title: Journal of Material Science & Engineering Volume: 6-7 Issue: 07 Pages: 68-68
  • DOI: 10.4172/2169-0022-c1-079
  • Open Access
• [Presentation] Magnetic nanoparticles for diagnostics and therapies (2019)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 7th China-Japan symposium on nanomedicine
  • Int'l Joint Research / Invited
• [Presentation] Magnetic nanoparticles toward to the diagnostics and therapies (2019)
  • Author(s): Yuko Ichiyanagi
  • Organizer: Nanomarials: Applicatins & Properties
  • Int'l Joint Research / Invited
• [Presentation] Local Structure Analysis of Magnetic Nanoparticles and Application for Theranostics (2019)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 6th International Conference on Theoretical, Materials and Condensed Matter Physics
  • Int'l Joint Research / Invited
• [Presentation] Ionization Ability of Functional Magnetic Nanoparticles and Gold Nanoparticles (2019)
  • Author(s): Kota Aoki
  • Organizer: 13th International Symposium on Nanomedicine
  • Int'l Joint Research
• [Presentation] Ionization Assisting Ability of Plasmonic Particles and Magnetic Nanoparticles as Matrices for Mass Spectrometry (2019)
  • Author(s): Kota Aoki
  • Organizer: Materials Research Meeting
  • Int'l Joint Research
• [Presentation] Particle size control and ionization assist ability of CoFe2O4 nanoparticles surrounded by SiO2 (2018)
  • Author(s): Y. Sahashi, K. Yoda, T. Ide, K. Fujiwara, A. Oshima, K. Kanda, Y. Ito, Y. Takahashi and Y. Ichiyanagi
  • Organizer: 12th International Symposium on Nanomedicine
  • Int'l Joint Research
• [Presentation] Functional magnetic nanoparticles for theranostics (2018)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 7th World Congress and Expo on Nanotechnology and Materials Science
  • Int'l Joint Research / Invited
• [Presentation] Functional Magnetic Nanoparticles as Theranostic Agents (2018)
  • Author(s): Yuko Ichiyanagi
  • Organizer: 12th International Symposium on Nanomedicine
  • Int'l Joint Research / Invited
• [Presentation] 磁気ナノ微粒子のイオン化支援機能 (2018)
  • Author(s): 佐橋侑馬，伊藤勇毅，井手太星，藤原康暉，大嶋晃人，神田康平，一柳優子
  • Organizer: 第54回熱測定討論会
• [Presentation] CoFe2O4/SiO2ナノ微粒子のSiO2層の変化によるMRI造影効果とイオン化支援機能 (2017)
  • Author(s): 橋本達哉, 井手太星, 藤原康暉,相原大輝,大嶋晃人, 神田康平, 一柳優子
  • Organizer: 応用物理学会２０１７秋季学術講演会
• [Presentation] SiO2包含Coフェライトナノ微粒子の粒径制御とイオン化支援機能 (2017)
  • Author(s): 相原大輝, 依田浩平, 藤原康暉, 井手太星, 橋本達哉, 大嶋晃人, 神田康平, 一柳優子
  • Organizer: 日本物理学会２０１７秋季大会
• [Presentation] Particle size control and ionization assist ability of CoFe2O4 nanoparticles surrounded by SiO2 (2017)
  • Author(s): D. Aihara, K. Yoda, K. Fujiwara, T. Ide, T. Hashimoto, A. Oshima, K. Kanda, Y. Ichiyanagi
  • Organizer: International Symposium on Nanomedcin (11th ISNM)
  • Int'l Joint Research
• [Presentation] Enhancement of MRI contract and ionization ability of CoFe2O4 / SiO2 nanoparticles depending on the amount of SiO2 (2017)
  • Author(s): HashimotoT. Ide, K. Fujiwara, D. Aihara, A. Oshima, K. Kanda, T. Y. Hosokai, A. Usui, Y.Ichiyanagi
  • Organizer: International Symposium on Nanomedcin (11th ISNM)
  • Int'l Joint Research
• [Presentation] Structural analysis and suppression of Jahn-Teller distortion in Cu-ferrite nanoparticles surrounded by amorphous SiO2 for biomedical application (2017)
  • Author(s): Koki Fujiwara, Shinji Kimura, Shunta Miyano, Taisei Ide, Yoshiyuki Hosokai, Akihito Usui, and Yuko Ichiyanagi
  • Organizer: Atimic Level Characterization (ALC'17)
  • Int'l Joint Research
• [Presentation] Ferromagnetic behavior and electronic characterization of ZnO nanoparticles for imaging probes (2017)
  • Author(s): T. Ide, K. Fujiwara, T. Hashimoto, K. Kanda, D. Aihara, A. Oshima and Y. Ichiyanagi,
  • Organizer: Atimic Level Characterization (ALC'17)
  • Int'l Joint Research