• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of tissue-equivalent radiation imaging devices using photochromism of organic molecules

Research Project

Project/Area Number 17K19082
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Nuclear engineering, Earth resources engineering, Energy engineering, and related fields
Research InstitutionTohoku University

Principal Investigator

Koshimizu Masanori  東北大学, 工学研究科, 准教授 (40374962)

Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywordsフォトクロミズム / ラジオクロミズム / ラジオフォトルミネッセンス / 異性化 / 生体等価性 / 光異性化 / 放射線検出 / 放射線イメージング
Outline of Final Research Achievements

We have developed radiation imaging organic materials on the basis of photochromic molecules. The organic materials have a tissue-equivalence characteristics of the absorption characteristics of radiation energy. The photochromic molecules change their absorption and photoluminescence properties upon excitation by UV photon absorption via isomerization. In this study, we observed that the similar isomerization behavior upon irradiations of ionizing radiation. We developed several types of radiochromic materials, in which the absorption spectra were significantly changed upon irradiation. In addition, we have developed radiophotoluminescence materials, in which photoluminescence characteristics appear upon irradiation. These results indicate that the use of the photochromic molecules is an effective tool to obtain radiation imaging organic materials.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果では、有機物ベースでの、また光学特性変化に基づいた放射線計測が可能となった。このことは、有機物を用いる利点であるところの、柔軟性や可塑性を利用した曲面や複雑な構造中での線量分布測定を可能とするものである。また、有機物を主成分とすることにより、生体と同様の放射線エネルギー付与特性を有する計測材料の合成が可能である。そのため、主にがんの放射線治療の計画策定における精密な線量分布測定への応用が可能となる。このことは、がん組織への線量集中および健常組織への照射線量の低減を通じて、がん治療の高度化に資するものであり、以って国民の健康増進に資するものである。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (11 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Radiophotoluminescent organic materials based on photoswitchable fluorescent diarylethene derivatives2019

    • Author(s)
      Kohei Asai, Takashi Ubukata, Masanori Koshimizu, Yutaka Fujimoto, Takayuki Yanagida, Hiroki Kawamoto, Keisuke Asai
    • Journal Title

      J. Mater. Sci. Mater. in Electron.

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiochromic properties of organic films based on a diarylethene molecule2019

    • Author(s)
      Kohei Asai, Masanori Koshimizu, Yutaka Fujimoto, Keisuke Asai
    • Journal Title

      Nucl. Instrum. Methods Phys. Res. A

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isomerization behavior of fulgide-type photochromic compounds upon X-ray irradiation2019

    • Author(s)
      Kawamura Ichiro、Koshimizu Masanori、Fujimoto Yutaka、Kawamoto Hiroki、Asai Keisuke
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 58 Issue: 2 Pages: 022003-022003

    • DOI

      10.7567/1347-4065/aaf715

    • NAID

      210000135291

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] adiochromic properties of organic _lms based on a diarylethene molecule2018

    • Author(s)
      Kohei Asai, Masanori Koshimizu, Yutaka Fujimoto, Keisuke Asai
    • Organizer
      SORMA XVII
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Organic radiochromic films based on photochromic spiropyran molecules2018

    • Author(s)
      K. Asai, M. Koshimizu, Y. Fujimoto, K. Asai
    • Organizer
      2018 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of radiochromic polymer films based on photochromic fulgides for X-ray detection2018

    • Author(s)
      Ichiro Kawamura, Masanori Koshimizu, Yutaka Fujimoto, Hiroki Kawamoto, Keisuke Asai
    • Organizer
      14th International Workshop on Ionizing Radiation Monitoring
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 紫外光およびX線照射によるAberchrome670の異性化挙動2018

    • Author(s)
      河村一朗,越水正典,藤本裕,川本弘樹,浅井圭介
    • Organizer
      次世代放射線シンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2, 3-ジヒドロ-2-スピロ-4’-[8’ -アミノナフタレン-1’ (4’h)-オン]ぺリミジンのX線照射に対するフォトクロミズム2018

    • Author(s)
      川本弘樹、越水正典、藤本裕、浅井圭介
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] X線照射によるフルギド系フォトクロミック化合物の異性化反応2018

    • Author(s)
      河村一朗, 越水正典, 藤本裕, 川本弘樹, 浅井圭介
    • Organizer
      第61回放射線化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 蛍光ジアリールエテン化合物添加ポリマー膜へのX 線照射に伴う蛍光スイッチング挙動2017

    • Author(s)
      浅井康平、生方俊、越水正典、藤本裕、浅井圭介
    • Organizer
      第28回光物性研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of radiochromic and radiophotoluminescence polymer films based on photochromic compounds for X-ray detection2017

    • Author(s)
      K. Asai, T. Ubukata, M. Koshimizu, Y. Fujimoto, K. Asai
    • Organizer
      The 13th International Workshop on Ionizing Radiation Monitoring
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 蛍光スイッチング特性を備えたフォトクロミック材料のX線照射による異性化挙動2017

    • Author(s)
      浅井康平、生方俊、越水正典、藤本裕、浅井圭介
    • Organizer
      日本セラミックス協会東北北海道支部研究発表会
    • Related Report
      2017 Research-status Report
  • [Presentation] 蛍光スイッチング特性を備えたジアリールエテン化合物のX線照射による異性化挙動2017

    • Author(s)
      浅井康平、生方俊、越水正典、藤本裕、浅井圭介
    • Organizer
      第60回放射線化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 蛍光スイッチング特性を備えたジアリールエテン化合物のX線照射による異性化挙動2017

    • Author(s)
      浅井康平、生方俊、越水正典、藤本裕、浅井圭介
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi