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Construction of novel self-oscillating polymer systems utilizing biochemical reaction

Research Project

Project/Area Number 17K19148
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Polymer, Organic materials, and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Yoshida Ryo  東京大学, 大学院工学系研究科(工学部), 教授 (80256495)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords機能性高分子 / ブロックコポリマー / 自励振動 / 振動反応 / 高分子ゲル / 刺激応答材料 / 生体材料 / 高分子材料 / ゲル
Outline of Final Research Achievements

Various biological behaviors are fueled by “respiration”, which is an example of catabolism. So far, we have reported various self-oscillating soft materials exhibiting bioinspired dynamic movements. These auton-omous polymer systems are driven by the Belousov-Zhabotinsky (BZ) reaction, which is analogous to the tricarboxylic acid (TCA) cycle that is an integral part of respiration. However, in the BZ reaction, the external addition of an oxidizing agent is necessary to initiate the oxidation pro-cess, which is realized by intracellular moieties such as ubiquinone in living systems. Herein, we realized self-oscillating micelles that are driven without the external addition of an oxidizing agent. This was achieved by embedding the oxidizing source into the structure of the self-oscillating AB diblock copolymers. This strategy introduces a new func-tion equivalent to intracellular oxidizing moieties, and is useful for the design of completely autonomous bio-inspired materials.

Academic Significance and Societal Importance of the Research Achievements

生体が示す高度な自律性に動機付けされた合成材料として、我々は自励振動高分子材料と呼ばれるコンセプトを世界に先駆けて提唱し、その研究を先導してきた。自励振動材料の応用研究へ向けた道を拓くため、本研究課題では、生理条件下で駆動する自励振動高分子材料の創出を目的とする。本研究課題が達成されれば、生体内で駆動する自律的なマイクロマシンや、周期的に薬物を放出する自律的ドラックデリバリーシステムなど、刺激応答材料を凌駕する革新的な自律性を持つ生体材料創製への大きな足掛かりとなると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Fabrication of Self‐Oscillating Micelles with a Built‐In Oxidizing Agent2020

    • Author(s)
      Toshiki Yoshizawa, Michika Onoda, Takeshi Ueki, Ryota Tamate, Aya Mizutani Akimoto, Ryo Yoshida
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 10 Pages: 3871-3875

    • DOI

      10.1002/anie.201913264

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mesenchylmal Stem Cell Culture on Poly(N-isopropylacrylamide) Hydrogel with Repeated Thermo-Stimulation2018

    • Author(s)
      A.M. Akimoto, E.H. Niitsu, K. Nagase, T. Okano, H. Kanazawa and R. Yoshida
    • Journal Title

      Int. J. Mol. Sci. 2018, 19(4), 1253; doi:10.3390/ijms19041253

      Volume: 19 Issue: 4 Pages: 1253-1262

    • DOI

      10.3390/ijms19041253

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 酸化剤供給部位を有するブロック共重合体の創製2020

    • Author(s)
      吉澤俊輝、小野田実真、上木岳士、玉手亮多、秋元文、吉田亮
    • Organizer
      第31回高分子ゲル研究討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸化剤供給部位を有する自励振動ブロック共重合体の創製2019

    • Author(s)
      吉澤俊輝、小野田実真、上木岳士、玉手亮多、秋元文、吉田亮
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 酸化剤供給部位を有する自励振動ミセルの創製2019

    • Author(s)
      吉澤俊輝、小野田実真、上木岳士、秋元文、吉田亮
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 臭素酸イオンを内包した自律的な構造振動を発現する AB 型ジブロック共重合体の創製2019

    • Author(s)
      吉澤俊輝、小野田実真、上木岳士、秋元文、吉田亮
    • Organizer
      第30回高分子ゲル研究討論会
    • Related Report
      2018 Research-status Report

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Published: 2017-07-21   Modified: 2021-02-19  

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