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乳酸菌とビフィズス菌の基準ゲノム作成と公開

Research Project

Project/Area Number 17K19248
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Agricultural chemistry and related fields
Research InstitutionNational Institute of Genetics

Principal Investigator

有田 正規  国立遺伝学研究所, 情報研究系, 教授 (10356389)

Co-Investigator(Kenkyū-buntansha) 川島 武士  国立遺伝学研究所, 情報研究系, 助教 (10378531)
Project Period (FY) 2017-06-30 – 2021-03-31
Project Status Granted (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords糖質加水分解酵素 / 糖転移酵素 / 食生活 / ビフィズス菌 / 乳酸菌 / 全ゲノム解析 / ゲノム / データベース / オープンデータ
Outline of Annual Research Achievements

多様な哺乳類と共生するビフィズス菌ゲノムの幅広さを解析するために、食生活が大きく異なる動物から新規のビフィズス菌同定を、ボローニャ大学のマタレッリ (P. Mattarelli, M. Modesto) グループと共同でおこなった。果実食のエジプトルーセットオオコウモリ (Rousettus aegyptiacus) 、草食のゲラダヒヒ (Theropithecus gelada) 、雑食のマーモセット (Callithrix jacchus) などから新規株の検出をおこない、それぞれ Bifidobacterium rousetti と B. vespertilionis, Alloscardovia theropitheci, B. jacchi と名付けた新種を報告した。(コウモリからは2種を新規同定した。)
これらのビフィズス菌類が様々な生物特異的に共生できるメカニズムを調べるため、多様な生物と共生できる株と比較しつつ糖代謝遺伝子の全ゲノム解析を実施した。とりわけ植物由来の多糖類や母乳中のオリゴ糖との関係を調査し,5単糖やシアル酸代謝との関連を見出した。結果として、ビフィズス菌類は動物の系統分類よりも食事の分類により近い糖質加水分解酵素、糖転移酵素の遺伝子集合を有することを見出した。またこうした糖関連酵素群のなかで基準ゲノムとしてすべてに保持されるものが非常に少ないことも明らかにした。また乳酸菌属における遺伝子水平伝搬(HGT)の概要を調査し、HGT候補となる遺伝子の探索パイプラインを構築している。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

多くの新規ビフィズス菌類を同定することができた。また食事と腸内細菌の関係を明らかにするのに十分なデータを取得できた。

Strategy for Future Research Activity

食事と腸内細菌の関係について論文化する。ボローニャ大学とは学生および教員の交流を実施する予定であったが、コロナウィルス対応のために中止せざるを得ない。ビデオ会議は可能だが、次世代の研究者養成という視点ではマイナスのため、代替案を考える必要がある。

Report

(3 results)
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report

Research Products

(14 results)

All 2019 2018 2017 Other

All Int'l Joint Research Journal Article Presentation

  • [Int'l Joint Research] Bologna University(イタリア)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ボローニャ大学(イタリア)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Bologna(Italy)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Bifidobacterium jacchi sp. nov., isolated from the faeces of a baby common marmoset (Callithrix jacchus)2019

    • Author(s)
      Modesto M, Watanabe K, Arita M, Satti M, Oki K, Sciavilla P, Patavino C, Camma C, Michelini S, Sgorbati B, Mattarelli P
    • Journal Title

      International Journal of Systematic and Evolutionary Microbiology

      Volume: 69 Pages: 2477-2485

    • DOI

      10.1099/ijsem.0.003518

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alloscardovia theropitheci sp. nov., isolated from the faeces of gelada baboon, the 'bleeding heart' monkey (Theropithecus gelada)2019

    • Author(s)
      Modesto M, Satti M, Watanabe K, Sciavilla P, Felis GE, Sandri C, Spiezio C, Arita M, Mattarelli P
    • Journal Title

      International Journal of Systematic and Evolutionary Microbiology

      Volume: 69 Pages: 3041-3048

    • DOI

      10.1099/ijsem.0.003584

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Characterization of Bifidobacterium species in feaces of the Egyptian fruit bat: Description of B. vespertilionis sp. nov. and B. rousetti sp. nov.2019

    • Author(s)
      Modesto M, Satti M, Watanabe K, Puglisi E, Morelli L, Huang CH, Liou JS, Miyashita M, Tamura T, Saito S, Mori K, Huang L, Sciavilla P, Sandri C, Spiezio C, Vitali F, Cavalieri D, Perpetuini G, Tofalo R, Bonetti A, Arita M, Mattarelli P
    • Journal Title

      Systematic and Applied Microbiology

      Volume: 42 Pages: 126017-126017

    • DOI

      10.1016/j.syapm.2019.126017

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Pseudofructophilic Leuconostoc citreum Strain F192-5, Isolated from Satsuma Mandarin Peel2019

    • Author(s)
      Maeno S, Tanizawa Y, Kajikawa A, Kanesaki Y, Kubota E, Arita M, Dicks L, Endo A
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 85

    • DOI

      10.1128/aem.01077-19

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isolation and Identification of Lactic Acid Bacteria from Environmental Samples2018

    • Author(s)
      Endo A, Tanizawa Y, Arita M
    • Journal Title

      Methods Mol Biol

      Volume: 1887 Pages: 3-13

    • DOI

      10.1007/978-1-4939-8907-2_1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus paragasseri sp. nov., a sister taxon of Lactobacillus gasseri, based on whole-genome sequence analyses2018

    • Author(s)
      Tanizawa Y, Tada I, Kobayashi H, Endo A, Maeno S, Toyoda A, Arita M, Nakamura Y, Sakamoto M, Ohkuma M, Tohno M
    • Journal Title

      International Journal of Systematic and Evolutionary Microbiology

      Volume: 68 Pages: 3512-3517

    • DOI

      10.1099/ijsem.0.003020

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fructophilic Lactic Acid Bacteria, a Unique Group of Fructose-Fermenting Microbes2018

    • Author(s)
      Endo A, Maeno S, Tanizawa Y, Kneifel W, Arita M, Dicks L, Salminen S
    • Journal Title

      Appl Environ Microbiol

      Volume: 84

    • DOI

      10.1128/aem.01290-18

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative Analysis of Probiotic Bacteria Based on a new Definition of core Genome2018

    • Author(s)
      Satti Maria、Tanizawa Yasuhiro、Endo Akihito、Arita Masanori
    • Journal Title

      Journal of Bioinformatics and Computational Biology

      Volume: 印刷中

    • DOI

      10.1142/s0219720018400127

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lactobacillus silagincola sp. nov. and Lactobacillus pentosiphilus sp. nov., isolated from silage2017

    • Author(s)
      Tohno M, Tanizawa Y, Irisawa T, Masuda T, Sakamoto M, Arita M, Ohkuma M, Kobayashi H
    • Journal Title

      International journal of systematic and evolutionary microbiology

      Volume: 67 Pages: 3639-3644

    • DOI

      10.1099/ijsem.0.002196

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Revealing the genomic differences between two subgroups in <i>Lactobacillus gasseri</i>2017

    • Author(s)
      Tada I, Tanizawa Y, Endo A, Tohno M, Arita M
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 36 Issue: 4 Pages: 155-159

    • DOI

      10.12938/bmfh.17-006

    • NAID

      130006132734

    • ISSN
      2186-3342
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparative Analysis of probiotic genus Bifidobacterium and Lactobacillus based on a new definition of core genome2017

    • Author(s)
      Maria Satti
    • Organizer
      GIW/BIOINFO2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-07-21   Modified: 2021-01-27  

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