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Basic research on construction of universal egg

Research Project

Project/Area Number 17K19332
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science, Animal science, and related fields
Research InstitutionKindai University

Principal Investigator

kato yoko  近畿大学, 農学部, 教授 (40278742)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords卵子 / 初期化 / ユニバーサル卵子 / 未受精卵 / 核移植 / クローン / 人工染色体
Outline of Final Research Achievements

The final goal of this study is to construct a universal egg cytoplasm. The ability to create an artificial egg cytoplasm that initializes somatic cell nuclei across species greatly contributes to breeding, increasing production of excellent livestock and reproduction, replication of rare animal species that require interspecific nuclear transfer. In this study, we were able to control mitochondrial abundance in oocyte and somatic cells in multiple animal species. In addition, we were able to construct an efficient nuclear transfer experimental system.

Academic Significance and Societal Importance of the Research Achievements

卵子の初期化能力の増強は、ヒト生殖補助医療分野にも貢献する。卵細胞質が持つ体細胞核の初期化機構と全能性誘導機構は、エピジェネティクス修正の関与が大きな鍵となっていることは明らかであるが、全体像についてはほとんど解明されていない。そのため、本研究を実施する過程において卵細胞質が持つ初期化機構の全体像を知る一端になると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

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