| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
The end of cellular life of epithelial cells is cell extrusion from epithelium. We aimed to reveal the molecular mechanism of cell extrusion and found a novel conserved process, that is extracellular vesicle formation in extruding cells. We further showed the mechanism of vesicle formation as well as its critical role for the prompt execution of cell extrusion. In summary, we characterized a novel mechanism of cell extrusion, the first compelling and conserved one to our knowledge.
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