Development of tools to analyze neuronal functional modules in the brain
| Project/Area Number |
17K19443
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience and related fields
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| Research Institution | Niigata University |
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Principal Investigator |
Ueno Masaki 新潟大学, 脳研究所, 教授 (40435631)
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| Project Period (FY) |
2017-06-30 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 神経回路 / 解析技術 / 神経細胞種 / 神経細胞 / 接続 |
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| Outline of Final Research Achievements |
This study is aimed to develop a variety of tools to analyze the connection patterns and functions of specific neural circuit in the central nervous system. We developed various tools to label synapses, intracellular organelles or a single soma, to detect or manipulate neural activities, to analyze functions of expressed molecules, and to remove neurons, in specific neuronal subtypes of the mouse brain. The library of developed tools enables labeling and manipulation of target neurons and will contribute to elucidate the connectivity and functions of specific neural circuits in the central nervous system.
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| Academic Significance and Societal Importance of the Research Achievements |
脳には多様な神経細胞種が存在するが、それらは特定の神経細胞とつながることで神経回路を構成し、機能を正しく発揮すると考えられている。しかし、こうした機能的な回路がどのような特異的な接続様式をもって機能を発揮しているのか、その動作原理について未だ理解が深まっていない。本研究では、神経回路内にある特定の神経細胞同士の接続パターンや機能を明らかにすることを可能とする様々な神経回路の解析技術を確立した。この解析技術のライブラリーは、中枢神経系に存在する多様な神経回路の接続や機能を解明する研究へ大きく貢献すると期待される。
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Report
(5 results)
Research Products
(54 results)
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[Journal Article] Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease.2020
Author(s)
Nagoya T, Kamimura K, Inoue R, Ko M, Owaki T, Niwa Y, Sakai N, Setsu T, Sakamaki A, Yokoo T, Kamimura H, Nakamura Y, Ueno M, Terai S.
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Journal Title
Neurogastroenterol Motil
Volume: 32
Issue: 5
DOI
Related Report
Peer Reviewed / Open Access
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