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Development of tools to analyze neuronal functional modules in the brain

Research Project

Project/Area Number 17K19443
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Neuroscience and related fields
Research InstitutionNiigata University

Principal Investigator

Ueno Masaki  新潟大学, 脳研究所, 教授 (40435631)

Project Period (FY) 2017-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords神経回路 / 解析技術 / 神経細胞種 / 神経細胞 / 接続
Outline of Final Research Achievements

This study is aimed to develop a variety of tools to analyze the connection patterns and functions of specific neural circuit in the central nervous system. We developed various tools to label synapses, intracellular organelles or a single soma, to detect or manipulate neural activities, to analyze functions of expressed molecules, and to remove neurons, in specific neuronal subtypes of the mouse brain. The library of developed tools enables labeling and manipulation of target neurons and will contribute to elucidate the connectivity and functions of specific neural circuits in the central nervous system.

Academic Significance and Societal Importance of the Research Achievements

脳には多様な神経細胞種が存在するが、それらは特定の神経細胞とつながることで神経回路を構成し、機能を正しく発揮すると考えられている。しかし、こうした機能的な回路がどのような特異的な接続様式をもって機能を発揮しているのか、その動作原理について未だ理解が深まっていない。本研究では、神経回路内にある特定の神経細胞同士の接続パターンや機能を明らかにすることを可能とする様々な神経回路の解析技術を確立した。この解析技術のライブラリーは、中枢神経系に存在する多様な神経回路の接続や機能を解明する研究へ大きく貢献すると期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (54 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (15 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 8 results) Presentation (32 results) (of which Int'l Joint Research: 6 results,  Invited: 16 results) Remarks (3 results)

  • [Int'l Joint Research] Burke Neurological Institute(米国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] シンシナティ小児病院(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] シンシナティ大学(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ソーク研究所(米国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Neuro-immune circuitry to restore in the brain and spinal cord injuries2021

    • Author(s)
      Ueno M
    • Journal Title

      Int Immunol

      Volume: in press Issue: 6 Pages: 311-325

    • DOI

      10.1093/intimm/dxab017

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury2020

    • Author(s)
      Ueno Masaki、Nakamura Yuka、Nakagawa Hiroshi、Niehaus Jesse K、Maezawa Mari、Gu Zirong、Kumanogoh Atsushi、Takebayashi Hirohide、Lu Qing Richard、Takada Masahiko、Yoshida Yutaka
    • Journal Title

      Cerebral Cortex

      Volume: 30 Issue: 11 Pages: 5702-5716

    • DOI

      10.1093/cercor/bhaa142

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Netrin-G1 regulates microglial accumulation along axons and supports the survival of layer V neurons in the postnatal mouse brain.2020

    • Author(s)
      Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S., and Yamashita, T.
    • Journal Title

      Cell Reports

      Volume: 31 Issue: 4 Pages: 107580-107580

    • DOI

      10.1016/j.celrep.2020.107580

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中枢神経障害による神経回路の再編と機能回復2020

    • Author(s)
      上野将紀
    • Journal Title

      新潟医学会雑誌

      Volume: 134 Pages: 7-12

    • NAID

      120006940016

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 随意運動をになう神経回路の再建 -基礎研究の現状と課題-2020

    • Author(s)
      上野将紀
    • Journal Title

      新潟県医師会報

      Volume: 842 Pages: 2-7

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Ghrelin-insulin-like growth factor-1 axis is activated via autonomic neural circuits in the non-alcoholic fatty liver disease.2020

    • Author(s)
      Nagoya T, Kamimura K, Inoue R, Ko M, Owaki T, Niwa Y, Sakai N, Setsu T, Sakamaki A, Yokoo T, Kamimura H, Nakamura Y, Ueno M, Terai S.
    • Journal Title

      Neurogastroenterol Motil

      Volume: 32 Issue: 5

    • DOI

      10.1111/nmo.13799

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 動きを生み出す脳の仕組みと謎2020

    • Author(s)
      上野将紀
    • Journal Title

      脳研コラム

      Volume: なし

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] Skilled movements in mice require inhibition of corticospinal axon collateral formation in the spinal cord by semaphorin signaling.2019

    • Author(s)
      Gu Z, Ueno M, Klinefelter K, Mamidi M, Yagi T, Yoshida Y.
    • Journal Title

      J Neurosci

      Volume: 39 Issue: 45 Pages: 8885-8899

    • DOI

      10.1523/jneurosci.2832-18.2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dual functions of microglia in the formation and refinement of neural circuits during development2019

    • Author(s)
      Konishi H, Kiyama H, Ueno M
    • Journal Title

      Int J Developmental Neuroscience

      Volume: 印刷中 Issue: 1 Pages: 18-25

    • DOI

      10.1016/j.ijdevneu.2018.09.009

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脊髄損傷と自律神経-臓器-免疫連関2019

    • Author(s)
      上野将紀
    • Journal Title

      実験医学

      Volume: 36 Pages: 2122-2128

    • Related Report
      2019 Research-status Report
  • [Journal Article] Corticospinal circuits from the sensory and motor cortices differentially regulate skilled movements through distinct spinal interneurons.2018

    • Author(s)
      Ueno M, Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, Crone SA, Goulding M, Baccei ML, Yoshida Y.
    • Journal Title

      Cell Reports

      Volume: 23 Issue: 5 Pages: 1286-1300

    • DOI

      10.1016/j.celrep.2018.03.137

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MARCKSL1 regulates spine formation in the amygdala and controls the hypothalamic-pituitary-adrenal axis and anxiety-like behaviors.2018

    • Author(s)
      Tanaka T, Shimizu S, Ueno M, Fujihara Y, Ikawa M, Miyata S.
    • Journal Title

      EBioMedicine

      Volume: 30 Pages: 62-73

    • DOI

      10.1016/j.ebiom.2018.03.018

    • NAID

      120006957428

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳・脊髄の障害による神経-免疫制御システムの破綻2018

    • Author(s)
      上野将紀
    • Journal Title

      実験医学

      Volume: 36 Pages: 370-376

    • Related Report
      2017 Research-status Report
  • [Journal Article] 特集 ミクログリアと精神・神経疾患 ミクログリアと脳発達2017

    • Author(s)
      上野将紀
    • Journal Title

      BRAIN and NERVE

      Volume: 69 Issue: 9 Pages: 985-997

    • DOI

      10.11477/mf.1416200858

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2017-09-01
    • Related Report
      2017 Research-status Report
  • [Journal Article] Rewiring of neural circuits and functional recovery following brain and spinal cord injuries2017

    • Author(s)
      上野将紀
    • Journal Title

      Leading Author's

      Volume: 6 Pages: e003

    • DOI

      10.7875/leading.author.6.e003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparison of corticospinal circuit between healthy and damaged brain.2021

    • Author(s)
      Sato T, Nakamura Y, Yoshida Y, Ueno M
    • Organizer
      生理研・脳研・霊長研合同シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] Rewiring of neural circuits in CNS injuries.2020

    • Author(s)
      Ueno M
    • Organizer
      Virtual DANDRITE lecture
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dysfunction of autonomic circuits and immune system in spinal cord injury.2020

    • Author(s)
      Ueno M
    • Organizer
      FENS 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuroprotective function of microglia in the postnatal brain.2020

    • Author(s)
      Fujita Y, Ueno M, Yamashita T
    • Organizer
      FENS 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経回路の再建と機能回復2020

    • Author(s)
      上野将紀
    • Organizer
      第8回神経と免疫を語る会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] NASH/NAFLDの病態における自律神経を介した臓器間ネットワークの関与2020

    • Author(s)
      1.上村顕也、名古屋拓郎、高昌良、井上良介、酒井規裕、丹羽佑輔、薛徹、坂牧僚、上村博輝、横尾健、中村由香、上野将紀、寺井崇二
    • Organizer
      第16回酸化ストレスと肝研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 中枢神経障害後の運動回路再建の試み2019

    • Author(s)
      上野将紀
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 自発的な身体運動は脳損傷後の機能回復を効果的に促進させる2019

    • Author(s)
      田中 貴士、上野将紀、本間 智
    • Organizer
      第24回日本基礎理学療法学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 巧緻運動を司る皮質脊髄路の接続-機能と再編2019

    • Author(s)
      上野将紀、中村由香、佐藤時春、吉田富
    • Organizer
      第24回日本基礎理学療法学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 外的・内的要因を標的にした脊髄損傷後の皮質脊髄路の再生効果の検証2019

    • Author(s)
      中村由香、上野将紀、吉田富
    • Organizer
      第24回日本基礎理学療法学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 中枢神経障害による神経回路の再編と機能回復2019

    • Author(s)
      上野将紀
    • Organizer
      第742回新潟医学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 脊髄損傷におけるSemaphorinによる軸索再生の阻害2019

    • Author(s)
      中村由香、上野将紀、中川浩、Jesse Niehaus、竹林浩秀、Qing R. Lu、高田昌彦、吉田富
    • Organizer
      第20回ORIGIN神経科学研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 中枢神経障害後の運動回路再建の試み2019

    • Author(s)
      上野将紀
    • Organizer
      リエゾンラボ炎症シンポジウム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Targeting extrinsic and intrinsic barriers to axon regeneration after spinal cord injury2019

    • Author(s)
      Nakamura Y, Ueno M, Niehaus J, Zheng Y, Yoshida Y
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Neuroprotective function of microglia in the developmental brain2019

    • Author(s)
      Fujita Y, Ueno M, Nakanishi T, Yamashita T
    • Organizer
      Neuro2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 巧緻運動をになう皮質脊髄路の構成と再編2019

    • Author(s)
      佐藤時春、中村由香、吉田富、上野将紀
    • Organizer
      第60回新潟生化学懇話会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脊髄損傷後の転写因子によるSemaphorinの発現制御と軸索再生阻害2019

    • Author(s)
      中村由香、上野将紀、中川浩、Jesse Niehaus、竹林浩秀、Qing R. Lu、高田昌彦、吉田富
    • Organizer
      第60回新潟生化学懇話会
    • Related Report
      2019 Research-status Report
  • [Presentation] Functional dissection of corticospinal circuit for skilled motor behavior.2019

    • Author(s)
      Ueno M, Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, Crone S, Goulding M, Baccei M, Yoshida Y.
    • Organizer
      第9回 脳研究所国際シンポジウム
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳卒中による運動回路の再編と機能の描出2019

    • Author(s)
      上野将紀
    • Organizer
      第44回日本脳卒中学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Genetic and functional dissection of corticospinal circuit for skilled motor behavior.2018

    • Author(s)
      Ueno M, Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, Crone S, Goulding M, Baccei M, Yoshida Y.
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脊髄の障害による神経-免疫連関の破綻2018

    • Author(s)
      上野将紀
    • Organizer
      第1回生体システム連関研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 巧みな動作を生み出す皮質脊髄路の多様な接続様式の形成2018

    • Author(s)
      上野将紀
    • Organizer
      第91回日本生化学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脊髄の障害による神経回路の再編と免疫抑制2018

    • Author(s)
      上野将紀
    • Organizer
      第83回日本インターフェロン・サイトカイン学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 巧緻運動を制御する皮質脊髄路の構成と動作原理.Genetic and functional dissection of corticospinal circuit for skilled motor behavior.2018

    • Author(s)
      Ueno M, Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, Crone S, Goulding M, Baccei M, Yoshida Y.
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脊髄損傷による自律神経回路の再編と免疫抑制2018

    • Author(s)
      上野将紀
    • Organizer
      第2回感覚免疫学研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脳脊髄障害後の神経回路の再編と機能2018

    • Author(s)
      上野将紀
    • Organizer
      神戸大学大学院セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 中枢神経の障害による神経回路の再編と機能の変容2018

    • Author(s)
      上野将紀
    • Organizer
      金沢大学遺伝子改変動物分野サイエンスセミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脳脊髄の障害と再生2018

    • Author(s)
      上野将紀
    • Organizer
      麻布大学大学院特別講義
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Genetic and functional dissection of corticospinal circuit for skilled motor behavior2018

    • Author(s)
      Ueno M, Ueno-Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, Crone S, Goulding M, Baccei M, Yoshida Y
    • Organizer
      Keystone symposium 2016 State of the Brain: Genetic Dissection of Brain Circuits and Behavior in Health and Disease (A2)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional dissection of corticospinal circuit for skilled motor behavior2017

    • Author(s)
      Ueno M, Ueno-Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, Crone S, Goulding M, Baccei M, Yoshida Y
    • Organizer
      次世代脳プロジェクト 2017年度冬のシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳・脊髄の障害による神経回路の再編と機能回復2017

    • Author(s)
      上野将紀
    • Organizer
      第2回 個体の中の細胞社会学セミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 巧緻運動を担う皮質脊髄路の接続と動作原理2017

    • Author(s)
      上野将紀
    • Organizer
      第18回 ORIGIN 神経科学研究会
    • Related Report
      2017 Research-status Report
  • [Remarks] 新潟大学脳研究所 システム脳病態学分野上野研究室 Research

    • URL

      http://www.bri.niigata-u.ac.jp/~system_neurodis/ueno/Research

    • Related Report
      2020 Annual Research Report
  • [Remarks] 動きを生み出す脳の仕組みと謎

    • URL

      https://www.bri.niigata-u.ac.jp/column/001306.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 巧みな動作のもとになる,多様な神経回路を発見しました

    • URL

      http://www.bri.niigata-u.ac.jp/result/molepath/001012.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2022-01-27  

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