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Development of curative therapy for polyglutamine disease by CAG repeat genome engineering

Research Project

Project/Area Number 17K19465
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Neuroscience and related fields
Research InstitutionAichi Medical University

Principal Investigator

Okada Yohei  愛知医科大学, 加齢医科学研究所, 教授 (30383714)

Project Period (FY) 2017-06-30 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsゲノム編集 / 神経変性疾患 / ポリグルタミン病 / 根治的治療法
Outline of Final Research Achievements

With the recent advances in genome editing technology, the development of novel therapeutics for hereditary neurodegenerative diseases is expected. In this study, we targeted Spinal Bulbar Muscular Atrophy (SBMA), which is caused by abnormal expansion of the polyglutamine tract (CAG repeat) of the androgen receptor (AR) gene, and developed genome editing technology to control the CAG repeat length of the AR. As a result, we succeeded in expanding the normal CAG repeats of wild-type ARs in cultured cell lines to reproduce the phenotype, and in shortening the abnormal CAG repeats of mutant ARs to normal length in SBMA disease-specific iPSCs. This technology may be applicable to the development of curative therapies for various hereditary neurodegenerative diseases.

Academic Significance and Societal Importance of the Research Achievements

多くの遺伝子性神経変性疾患では、リピート配列の伸長により発症することが知られており、リピート配列の制御が根治的治療法の開発につながると考えられる。本研究の成果により、リピート配列の制御が可能になれば、様々な神経変性疾患の根治的治療法の開発につながると考えられる。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (96 results)

All 2022 2021 2020 2019 2018 2017 Other

All Journal Article (21 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 11 results) Presentation (70 results) (of which Int'l Joint Research: 15 results,  Invited: 13 results) Book (1 results) Remarks (4 results)

  • [Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022

    • Author(s)
      Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y*, Sobue G*
    • Journal Title

      Journal of Neuroscience

      Volume: 42 Issue: 47 Pages: 8881-8896

    • DOI

      10.1523/jneurosci.0455-22.2022

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SBMAの病態解明・治療開発研究2022

    • Author(s)
      岡田梨奈、岡田洋平
    • Journal Title

      生体の科学

      Volume: 73 Pages: 480-481

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis2021

    • Author(s)
      Koike H, Mouria N, Fukamia Y, Iijima M, Matsuo K, Yagi N, Saito A, Nakamura H, Takahashi K, Nakae Y, Okada Y, Tanaka F, Sobue G, Katsuno M
    • Journal Title

      Commun Biol.

      Volume: 421 Pages: 117305-117305

    • DOI

      10.1016/j.jns.2020.117305

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.2021

    • Author(s)
      Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M.
    • Journal Title

      Mol Ther Nucleic Acids.

      Volume: 24 Pages: 1-10

    • DOI

      10.1016/j.omtn.2021.02.007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Human Neuromuscular Tissue-on-a-Chip Model on a 24-Well-Plate-Format Compartmentalized Microfluidic Device2021

    • Author(s)
      Yamamoto K, Yamaoka N, Imaizumi Y, Nagashima T, Furutani T, Ito T, Okada Y, Honda H, Shimizu K
    • Journal Title

      Lab on a Chip

      Volume: 21 Issue: 10 Pages: 1897-1907

    • DOI

      10.1039/d1lc00048a

    • NAID

      120007169522

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.2021

    • Author(s)
      Taguchi S, Koide H, Oiwa H, Hayashi M, Ogawa K, Ito C, Nakashima K, Yuasa T, Yasumoto A, Ando H, Fujikake A, Fukuoka T, Tokui K, Izumi M, Tsunoda Y, Kawagashira Y, Okada Y, Niwa JI, Doyu M.
    • Journal Title

      PLoS One.

      Volume: 16 Issue: 7 Pages: e0255274-e0255274

    • DOI

      10.1371/journal.pone.0255274

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.2020

    • Author(s)
      Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okada Y, Nagasaki M, Sobue G. et al.,
    • Journal Title

      Commun Biol.

      Volume: 23 Issue: 1 Pages: 526-526

    • DOI

      10.1038/s42003-020-01251-2

    • NAID

      120007178464

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] n vitro model of human skeletal muscle tissues with contractility fabricated by immortalized human myogenic cells.2020

    • Author(s)
      Nagashima T, Hadiwidjaja S, Ohsumi S, Murata A, Hisada T, Kato R, Okada Y, Honda H, Shimizu K
    • Journal Title

      Adv Biosyst.

      Volume: 11 Issue: 11

    • DOI

      10.1002/adbi.202000121

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of oxygen tension, acidosis, and cell density is crucial for neural differentiation of human induced pluripotent stem cells.2020

    • Author(s)
      Okada R, Onodera K, Ito T, Doyu M, Okano HJ, Okada Y
    • Journal Title

      Neurosci. Res.

      Volume: - Pages: 30043-2

    • DOI

      10.1016/j.neures.2020.01.015

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs2020

    • Author(s)
      Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y
    • Journal Title

      Mol. Brain

      Volume: 13 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s13041-020-0561-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions2019

    • Author(s)
      Nao Yamaoka、Shimizu Kazunori、Yu Imaizumi、Takuji Ito、Yohei Okada、Hiroyuki Honda
    • Journal Title

      BioChip Journal

      Volume: in press Issue: 2 Pages: 127-132

    • DOI

      10.1007/s13206-018-3202-3

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.2019

    • Author(s)
      Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, et al.
    • Journal Title

      EBioMedicine

      Volume: 45 Pages: 362-378

    • DOI

      10.1016/j.ebiom.2019.06.013

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy2019

    • Author(s)
      Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M
    • Journal Title

      Nat. Commun.

      Volume: 10 Pages: 4262-4262

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532019

    • Author(s)
      Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H.
    • Journal Title

      Cell Rep.

      Volume: 30 Issue: 4 Pages: 1195-1207

    • DOI

      10.1016/j.celrep.2019.12.064

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 疾患特異的iPS細胞を用いた神経変性疾患の病態解析と新規治療法開発2019

    • Author(s)
      岡田洋平
    • Journal Title

      臨床雑誌内科

      Volume: 123 Pages: 1315-1319

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] ゲノム編集を用いた神経変性疾患の病態解明と治療法開発2018

    • Author(s)
      田中智史、今釜史郎、石黒直樹、岡田洋平
    • Journal Title

      整形外科

      Volume: 69 Pages: 922-922

    • Related Report
      2018 Research-status Report
  • [Journal Article] ES細胞由来運動神経細胞移植による末梢神経の運動機能再建2018

    • Author(s)
      新海宏明、丹羽智史、佐伯将臣、平田仁、岡田洋平
    • Journal Title

      整形外科

      Volume: 69 Pages: 1322-1322

    • Related Report
      2018 Research-status Report
  • [Journal Article] 疾患特異的iPS細胞を用いた神経変性疾患の病態解析・創薬研究2018

    • Author(s)
      岡田洋平、祖父江元
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 328-332

    • Related Report
      2017 Research-status Report
  • [Journal Article] Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy.2017

    • Author(s)
      Nakatsuji H, Araki A, Hashizume A, Hijikata Y, Yamada S, Inagaki T, Suzuki K, Banno H, Suga N, Okada Y, Ohyama M, Nakagawa T, Kishida K, Funahashi T, Shimomura I, Okano H, Katsuno M, Sobue G.
    • Journal Title

      J Neurol.

      Volume: in press Issue: 5 Pages: 839-847

    • DOI

      10.1007/s00415-017-8405-3

    • NAID

      120006331845

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Teratoma Formation Assay for Assessing Pluripotency and Tumorigenicity of Pluripotent Stem Cells2017

    • Author(s)
      Miyawaki Shingo、Okada Yohei、Okano Hideyuki、Miura Kyoko
    • Journal Title

      BIO-PROTOCOL

      Volume: 7 Issue: 16

    • DOI

      10.21769/bioprotoc.2518

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 難治性神経変性疾患における治療開発~患特異的iPS細胞を用いた神経疾患モデルの構築と治療薬の開発2017

    • Author(s)
      岡田洋平、祖父江元
    • Journal Title

      トランスレーショナルリサーチを支援する遺伝子医学MOOK

      Volume: 32 Pages: 110-116

    • Related Report
      2017 Research-status Report
  • [Presentation] iPS細胞を用いたSBMAの病態解明、治療開発研究2022

    • Author(s)
      岡田洋平
    • Organizer
      SBMAの会 2022年度医療セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた神経疾患の病態解明と治療戦略2022

    • Author(s)
      岡田洋平
    • Organizer
      第62回日本定位・機能神経外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2022

    • Author(s)
      小野寺一成, 下門大祐, Bruno De Araujo Herculano1, 石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央,岡野栄之,岡田洋平
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2022

    • Author(s)
      大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋, 岡田洋平, 勝野雅央, 山中 宏二
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第33回日本末梢神経学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第33回日本末梢神経学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Bulk differentiation of iPSCs into contractible muscles for muscular disease modeling2022

    • Author(s)
      Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の早期病態解明と治療開発2022

    • Author(s)
      小野寺一成、下門大祐、石原康晴、太田明伸、Muhammad Irfanur Rashid、伊藤卓治、岡田梨奈、細川好孝、道勇学、祖父江元、勝野雅央、岡野栄之、岡田洋平
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 疾患特異的iPS細胞を用いた運動ニューロン疾患の病態解明と治療開発2021

    • Author(s)
      岡田洋平
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 病態に基づいた神経疾患の再生戦略2021

    • Author(s)
      岡田洋平
    • Organizer
      浜松医科大学尖端医学シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 疾患特異的iPS細胞を用いた神経・筋病態の解明2021

    • Author(s)
      岡田洋平
    • Organizer
      第60回日本臨床検査医学会東海・北陸支部総会、第344回日本臨床化学会東海・北陸支部例会 連合大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2021

    • Author(s)
      小野寺一成, 下門大祐, de Ara?jo Herculano B,石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid MI, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田 洋平
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] SynGAP variant from ALS cohort causes spine abnormality by excessive recruitment of FUS and hnRNPK2021

    • Author(s)
      横井聡, 伊藤卓治, 佐橋健太郎, 中村亮一, 石垣診祐, 熱田直樹, 勝野雅央, 岡田 洋平, 祖父江元
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 脳卒中患者における自律神経機能と病状との関連2021

    • Author(s)
      中島 康自, 小出 弘文, 林 未久, 伊藤 千弘, 湯淺 知子, 安本 明弘, 安藤 宏明, 田口 宗太郎, 藤掛 彰史, 福岡 敬晃, 徳井 啓介, 川頭 祐一, 岡田 洋平, 丹羽 淳一, 道勇 学
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Allele selective suppression of mutant polyQ protein by LNP-delivered siRNA targeting CAG expansions2021

    • Author(s)
      蛭薙智紀, 佐橋健太郎, 立川潔, Leu A, Nguyen M, Mukthavaram R, Karmali P, Chivukula P, 藤内玄規, 飯田円, 小野寺一成, 大山学, 岡田 洋平, 岡野栄之, 勝野雅央
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] The effects of g-secretase inhibitor on differentiation of iPSC-derived neurons2021

    • Author(s)
      福井ナナミ、伊藤卓治、杉山香織、岡田梨奈、小野寺一成、Zohora Khatun、道勇学、岡田洋平
    • Organizer
      第44回日本神経科学大会 CJK第1回国際会議
    • Related Report
      2021 Research-status Report
  • [Presentation] Establishment of hiPSC-derived functional neuromuscular models for the analysis of neuromuscular diseases2021

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、田中智史、下門大祐、岡野栄之、道勇学、岡田洋平
    • Organizer
      ヒトiPS細胞由来運動ニューロンと骨格筋を用いた機能的神経筋共培養モデルの構築、第44回日本神経科学大会 CJK第1回国際会議
    • Related Report
      2021 Research-status Report
  • [Presentation] Efficient, reproducible, and functional differentiation of human induced pluripotent stem cells (iPSCs) into skeletal muscles for muscular disease modeling.2021

    • Author(s)
      Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
    • Organizer
      PACTALS 2021 NAGOYA
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elucidating early pathophysiology of Spinal-bulbar muscular atrophy using diseasespecific iPSCs.2021

    • Author(s)
      Onodera K, Shimojo D, de Ara?jo Herculano B, Ishihara Y, Yoda M, Ota A, Rashid MI, Ito T, Okada R, Hosokawa Y, Doyu M, Sobue G, Katsuno M, Okano H, Okada Y
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of iPSC-derived neuromuscular co-culture model for the analysis of non-cell autonomous neurodegeneration in motor neuron diseases2021

    • Author(s)
      Ito T, Rashid MI, Tanaka S, Shimojo D, Okano H, Doyu M, Okada Y.
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient, reproducible and functional differentiation of human iPSCs into skeletal muscles for muscular disease modeling.2021

    • Author(s)
      Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 疾患iPS細胞を用いた運動ニューロン疾患の病態解明と治療開発2020

    • Author(s)
      岡田洋平
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 末梢神経障害の機能再建におけるヒトiPS細胞の可能性と問題点2020

    • Author(s)
      岡田洋平
    • Organizer
      第31回日本末梢神経学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 疾患特異的iPS細胞を用いた神経・筋病態の解明2020

    • Author(s)
      岡田洋平
    • Organizer
      第6回日本筋学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Drug screening for early pathology of SBMA using disease specific iPSCs and novel biomarkers2020

    • Author(s)
      エルクラノ ブルーノ、小野寺一成、伊藤卓治、下門大祐、岡田梨奈、勝野雅央、道勇学、祖父江元、岡野栄之、岡田洋平
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 疾患iPS細胞による神経・筋共培養を活用した神経変性疾患の病態解析2020

    • Author(s)
      伊藤卓治、小野寺一成、下門大祐、田中智史、岡田梨奈、ラシッド ムハンマド イルファヌール、道勇学、岡野栄之、岡田洋平
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Efficient and reproducible skeletal muscle differentiation from iPSCs for muscular diseases modeling2020

    • Author(s)
      ラシッド ムハンマド イルファヌール、伊藤卓治、小野寺一成、道勇学、岡田洋平
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Elucidation of early pathophysiology of spinal-bulbar muscular atrophy using disease- specific iPSCs.2020

    • Author(s)
      Onodera K, Shimojo D,Yoda M, Ishihara Y, Ota A, Yano M, Miya F, Rashid MI, Ito T, Okada R, Tsunodna T, Hosokawa Y, Doyu M,Katsuno M, Okano H, Sobue G, Okada Y.
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Pathophysiological analysis of spinal and bulbar muscular atrophy using disease-specific iPSCs.2019

    • Author(s)
      Onodera K, Shimojo D, Yoda M, Ishihara Y, Ito T, Okada R, Doyu M, Katsuno M, Okano H, Sobue G, Okada Y
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] FUS depletion induces spine abnormality and SynGAP depletion in hiPSC-derived motor neuron.2019

    • Author(s)
      Yokoi S, Ito T, Sahashi K, Ishigaki S, Katsuno M, Okada Y, Sobue G.
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] The effects of hypoxia on differentiation and maturation of human induced pluripotent stem cell-derived neural progenitors.2019

    • Author(s)
      Okada Y, Okada R, Li J, Onodera K, Ito T, Okano HJ, Doyu M
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reconstruction of motor function in peripheral nerves by transplanatation of human iPSC-derived motor neuron progenitors.2019

    • Author(s)
      Niwa S, Saeki M, Shinkai H, Kurimoto S, Hirata H, Doyu M, Okada Y
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elucidation of non-cell autonomous neurodegeneration in spinal and bulbar muscular atrophy using iPSC-derived neuromuscular models.2019

    • Author(s)
      Ito T, Tanaka S, Shimojo D, Doyu M, Okano H, Okada Y
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] iPS細胞を用いた神経疾患研究2019

    • Author(s)
      岡田洋平
    • Organizer
      SBMAの会 第8回医療セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] iPS細胞を用いたNMJ形成②2019

    • Author(s)
      岡田洋平
    • Organizer
      AMED再生医療実現拠点ネットワークプログラム「疾患特異的iPS細胞の利活用促進・難病研究加速プログラム」研究拠点I疾患別ミーティング
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の早期病態の解明2019

    • Author(s)
      岡田洋平、小野寺一成、依田真由子、伊藤卓治、岡田梨奈、勝野雅央、道勇学、祖父江元、岡野栄之
    • Organizer
      新学術領域「脳たんぱく質老化と認知症制御」第9回班員会議
    • Related Report
      2018 Research-status Report
  • [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症の病態解明と新規治療標的の探索2019

    • Author(s)
      岡田洋平
    • Organizer
      2018年度6事業合同成果報告会「疾患克服への挑戦2018」
    • Related Report
      2018 Research-status Report
  • [Presentation] 末梢神経損傷におけるヒトiPS細胞由来運動神経前駆細胞を用いた運動機能再建2019

    • Author(s)
      丹羽智史、佐伯将臣、新海宏明、栗本秀、平田仁、岡田洋平
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 疾患iPS細胞による神経・筋共培養を活用した新たな病態解析システムの構築2019

    • Author(s)
      伊藤卓治、田中智史、下門大祐、道勇学、岡野栄之、岡田洋平
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] マイクロデバイスを用いたヒトiPS由来運動神経細胞と骨格筋細胞の三次元共培養2019

    • Author(s)
      山岡奈央、清水一憲、今泉裕、伊藤卓治、岡田洋平、本多裕之
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Controversy3 PDの病態はiPS細胞で再現できるか ― Yes -2018

    • Author(s)
      岡田洋平
    • Organizer
      第12回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] iPS細胞を用いた神経疾患研究2018

    • Author(s)
      岡田洋平
    • Organizer
      第66回 脳の医学生物学研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Pathophysiological analysis of spinal and bulbar muscular atrophy using disease-specific iPSCs2018

    • Author(s)
      Onoderea K, Ito T, Shimojo D, Ishihara Y, Doyu M, Katsuno M, Okano H, Sobue G, Okada Y.
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Pathophysiological analysis of Spinal-bulbar muscular atrophy using disease specific iPSCs.2018

    • Author(s)
      Okada Y, Onodera K, Ito T, Shimojo D, Okada R, Ishihara Y,Tanaka S, Katsuno M,Doyu M, Sobue G,Okano H.
    • Organizer
      ISSCR 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of iPSC-derived neuromuscular models for the analysis of non-cell autonomousneurodegeneration in motor neuron diseases.2018

    • Author(s)
      Ito T, Tanaka S, Shimojo D, Doyu M, Okano H, Okada Y.
    • Organizer
      ISSCR 2018 Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の早期病態の解明2018

    • Author(s)
      岡田洋平、小野寺一成、依田真由子、伊藤卓治、勝野雅央、道勇学、祖父江元、岡野栄之
    • Organizer
      新学術領域「脳たんぱく質老化と認知症制御」第8回班員会議・第4回リトリート
    • Related Report
      2018 Research-status Report
  • [Presentation] iPS細胞を用いた神経筋接合部可視化システムおよび機能評価系の構築2018

    • Author(s)
      伊藤卓治、田中智史、下門大祐、道勇学、岡野栄之、岡田洋平
    • Organizer
      新学術領域「脳たんぱく質老化と認知症制御」第8回班員会議・第4回リトリート
    • Related Report
      2018 Research-status Report
  • [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の早期病態の解析2018

    • Author(s)
      岡田洋平、小野寺一成、伊藤卓治、岡田梨奈、勝野雅央、道勇学、祖父江元、岡野栄之
    • Organizer
      新学術領域「脳たんぱく質老化と認知症制御」第7回班員会議
    • Related Report
      2017 Research-status Report
  • [Presentation] Pathophysiological analysis of spinal-bulbar muscular atrophy using disease specific iPSCs (シンポジウム)2017

    • Author(s)
      Okada Y, Onodera K,Ito T, Shimojo D, Ishihara Y, Tanaka S, Katsuno M,Doyu M,Sobue G,Okano H
    • Organizer
      Society for Neuroscience Annual Meeting, Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症の病態解析と新規治療法の開発研究 (招待講演)2017

    • Author(s)
      岡田洋平
    • Organizer
      愛知県特定疾患研究協議会、平成29年度難病教育講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 疾患特異的iPS細胞を用いた神経変性疾患の早期病態の解明2017

    • Author(s)
      岡田洋平、小野寺一成、伊藤卓治、李家?、岡田梨奈、勝野雅央、道勇学、祖父江元、岡野栄之
    • Organizer
      新学術領域「脳たんぱく質老化と認知症制御」第6回班員会議
    • Related Report
      2017 Research-status Report
  • [Presentation] iPS細胞を用いた神経筋接合部可視化システムの構築2017

    • Author(s)
      伊藤卓治、田中智史、下門大祐、道勇学、岡野栄之、岡田洋平
    • Organizer
      新学術領域「脳たんぱく質老化と認知症制御」第6回班員会議
    • Related Report
      2017 Research-status Report
  • [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の病態解析2017

    • Author(s)
      小野寺一成、下門大祐、石原康晴、道勇学、勝野雅央、祖父江元、岡野栄之、岡田洋平
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 神経筋接合部のライブセルイメージング2017

    • Author(s)
      伊藤卓治、田中智史、下門大祐、道勇学、岡野栄之、岡田洋平
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ゲノム編集を用いた骨格筋における球脊髄性筋萎縮症(SBMA)の病態解析2017

    • Author(s)
      田中智史、伊藤卓治、太田明伸、曽根岳史、下門大祐、今釜史郎、細川好孝、道勇学、岡野栄之、岡田洋平
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒトiPS細胞由来運動神経細胞移植による末梢神経における運動機能の再建2017

    • Author(s)
      丹羽智史、新海宏明、小野寺一成、伊藤卓司、田中智史、李家?、栗本秀、中野智則、道勇学、平田仁、岡田洋平
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 低酸素がヒトiPS細胞由来神経系前駆細胞の分化成熟に与える影響2017

    • Author(s)
      岡田洋平、李家イ、岡田梨奈、小野寺一成、伊藤卓司、岡野ジェイムズ洋尚、勝野雅央、道勇学、岡野栄之、祖父江元
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] The analysis of neuromuscular pathology of spinal-bulbar muscular atrophy using iPSC-derived disease model2017

    • Author(s)
      Okada Y, Ito T, Tanaka T, DShimojo D, Onodera K, Katsuno M, Okano H, Sobue G, Doyu D
    • Organizer
      第23回世界神経学会議・第58回日本神経学会学術大会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pathophysiological analysis of spinal and bulbar muscular atrophy using disease-specific iPSCs.2017

    • Author(s)
      Onodera K, Shimojo D, Ishihara Y, Doyu M, Okano H, Katsuno M, Sobue G, Okada Y
    • Organizer
      第23回世界神経学会議・第58回日本神経学会学術大会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Therapeutic approach for neurodegenerative diseases focusing on early pathogenesis and disease accelerating factors using disease specific iPSCs2017

    • Author(s)
      Okada Y, Onodera K, Ito T, Shimojo D, Katsuno M, Doyu M, Sobue G, Okano H
    • Organizer
      新学術領域研究「脳タンパク質老化と認知症制御」第2回国際シンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pathophysiological analysis of skeletal muscles in spinal bulbar muscular atrophy by genome editing of CAG repeats2017

    • Author(s)
      Tanaka S, Ito T, Ota A, Sone T, Shimojo D, Imagama S, Hosokawa Y, Doyu M, Okano H, Okada Y
    • Organizer
      Society for Neuroscience Annual Meeting, Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of iPSC-derived neuromuscular models for pathological analysis and drug screening2017

    • Author(s)
      Ito T, Tanaka S, Shimojo D, Doyu M, Okano H, Okada Y
    • Organizer
      Society for Neuroscience Annual Meeting, Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] iPS細胞由来神経筋共培養モデルを用いた神経筋疾患の病態解析2017

    • Author(s)
      伊藤卓治、田中智史、下門大祐、道勇学、岡野栄之、岡田洋平
    • Organizer
      第40回日本分子生物学会年会・生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ゲノム編集を用いた球脊髄性筋萎縮症(SBMA)における骨格筋病態の解析2017

    • Author(s)
      田中智史、伊藤卓治、太田明伸、曽根岳史、今釜史郎、細川好孝、岡野栄之、道勇学、岡田洋平
    • Organizer
      第40回日本分子生物学会年会・生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 低酸素がヒトiPS細胞由来神経系前駆細胞の分化成熟に与える影響2017

    • Author(s)
      岡田梨奈、李家イ、小野寺一成、伊藤卓治、勝野雅央、祖父江元、岡野栄之、道勇学、岡野ジェイムズ洋尚、岡田洋平
    • Organizer
      第40回日本分子生物学会年会・生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の病態解析2017

    • Author(s)
      小野寺一成、下門大祐、伊藤卓治、石原康晴、勝野雅央、道勇学、祖父江元、岡野栄之、岡田洋平
    • Organizer
      第40回日本分子生物学会年会・生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
  • [Book] 神経疾患治療ストラテジー2017

    • Author(s)
      祖父江元、伊藤卓治、岡田洋平、他
    • Total Pages
      451
    • Publisher
      中山書店
    • ISBN
      9784521745435
    • Related Report
      2017 Research-status Report
  • [Remarks] 愛知医科大学 神経内科 神経変性疾患・幹細胞研究室

    • URL

      https://okadalab-hp.com/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Remarks] 愛知医科大学医学部内科学講座(神経内科)

    • URL

      https://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
  • [Remarks] 愛知医科大学 神経内科

    • URL

      https://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html

    • Related Report
      2019 Research-status Report
  • [Remarks]

    • URL

      https://researchmap.jp/Yohei_Okada/

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2024-01-30  

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