| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
We have found for the first time that the plant alkaloid, calycanthine, functions as an asymmetric organocatalyst. Thus, in the Michael addition reaction of the oxindole derivative with nitroethene, when 20 mol% of calycanthine or a derivative having a substituent introduced on its benzene ring was used, an optically active substance was obtained with a maximum enantiomeric excess of 41%. Furthermore, it has been suggested that the introduction of a secondary amino group on the benzene ring of calycanthine is indispensable to enhance the molecular recognition ability of nucleobases and calycanthines.
|
