A novel technology for regulating blood brain barrier
| Project/Area Number |
17K19487
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmaceutical Sciences and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
樋野 展正 大阪大学, 薬学研究科, 助教 (90469916)
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| Research Collaborator |
KONDOH masuo
TAKEDA hiroyuki
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 血液脳関門 / Claudin-5 / 抗体 / 血管内皮細胞 / 薬学 / DDS / 血管生物学 |
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| Outline of Final Research Achievements |
The blood-brain barrier function of the cerebrovascular system protects the brain by preventing foreign matter from entering the brain. On the other hand, the blood-brain barrier also hinders the transfer of drugs to the brain, which hinders the development of drugs for treating brain diseases. In this study, we aimed to develop a technology to temporarily loosen the blood-brain barrier for the effective drug delivery to the brain. Since the blood-brain barrier is generated by tight junction of vascular endothelial cells, we generated anti-human Claudin-5 antibodies that inhibit the junction. In addition, in order to evaluate the blood-brain barrier control activity of these antibodies, we generated mice having human Claudin-5 and obtained data suggesting that the anti-Claudin-5 antibodies have the activity of loosening the blood-brain barrier.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会の我が国ではアルツハイマー病など脳疾患の患者が増加の一途を辿っている。製薬企業の努力にもかかわらず、脳疾患治療薬の開発が難航する理由の一つに、薬の脳移行を妨げる血液脳関門の存在がある。本来、血液脳関門は、脳を異物侵入から守る生体防御機構であるが、脳疾患の薬の脳への移行も阻害してしまうため、優れた治療薬の候補分子が、脳に移行しないという理由で薬にならないという現状がある。我々の今回の研究は、血液脳関門を緩め、脳に効率よく薬を届ける技術の開発研究であり、今後の脳疾患治療薬開発に貢献すると期待される。
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Angubindin-1, a novel paracellular absorption enhancer acting at the tricellular tight junction.2017
Author(s)
Krug SM, Hayaishi T, Iguchi D, Watari A,Takahashi A, Fromm M, Nagahama M, Takeda H, Okada Y,Sawasaki T, Doi T, Yagi K, Kondoh M
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Journal Title
J. Control. Release.
Volume: 260
Pages: 1-11
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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