| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Although neuropathic and inflammatory pain are unbearable chronic pain by various diseases, effective analgesics with few side effects have yet to be developed. In this study, we aimed to establish the control system of neurotransmission for transporter-targeted drug discovery. We identified several selective inhibitors of vesicular neurotransmitter transporter, which were more effective for chronic pain with few side effects than existing drugs. These compounds are expected to become new drug candidates for neuropathic and inflammatory pain.
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