| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The optical resolution method of racemic α-trifluoromethyl (αCF3)-amino acids using chiral BINOL esters was developed. Also, we synthesized several chiral phase-transfer catalysts derived from quinidine. Using a chiral phase-transfer catalyst, we synthesized an optically active αCF3-amino acid with 78% ee. We synthesized diastereomeric two peptides Cbz-(L-Leu)2-{(S)- or (R)-CF3-Aib}-(L-Leu)2-OMe, and studied the preferred conformation of peptides using 1H NMR and CD spectra, and also X-ray crystallographic analysis.
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