Development of novel method to improve the lipoquality of neurons
| Project/Area Number |
17K19500
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmaceutical Sciences and related fields
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 脂肪酸 / 脳 / リーリン / リポタンパク質 / 精神疾患 / 神経細胞 / リポクオリティ / アルツハイマー病 |
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| Outline of Final Research Achievements |
Reelin is essential for the development and function of the mammalian brain and the receptors for Reelin, belong to the low-density lipoprotein receptor family, but it is not known whether Reelin is involved in the brain lipid metabolism. We found that Reelin-deficient mouse brain exhibited several compositional changes in phospholipids. The ratio of phospholipids containing one saturated
fatty acid (FA) and one docosahexaenoic acid (DHA) or arachidonic acid (ARA) decreased and the ratio of phospholipids containing one monounsaturated FA and one DHA or ARA increased. The ratio of phospholipids containing Mead acid increased. Therefore, Reelin can upregulate the amount of polyunsaturated fatty acids in the brain, which will help ameliorate neuropsychiatric and neurodegenerative disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果は、「リーリンの機能」「脳の脂肪酸組成」「精神神経疾患の発症」の３者間に今まで漠然と存在した相関を包括的に理解できる可能性を示唆しており、概念的には大きな進歩であると考えている。また、アルツハイマー病などの難治性神経疾患に対する新たな治療法開発の糸口にもなり得るものである。
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Report
(3 results)
Research Products
(38 results)
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[Journal Article] Reelin deficiency leads to aberrant lipid composition in mouse brain.2018
Author(s)
Mizukami T, Ikeda K, Shimanaka Y, Korogi K, Zhou C, Takase H, Tsuiji H, Kono N, Kohno T, Arai H, Arita M, Hattori M.
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Journal Title
Biochem Biophys Res Commun
Volume: 505
Issue: 1
Pages: 81-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.2018
Author(s)
Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N.
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 13046-13046
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin2017
Author(s)
Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M
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Journal Title
J Neurosci
Volume: 37
Issue: 12
Pages: 3181-3191
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin2017
Author(s)
Himari Ogino, Arisa Hisanaga, Takao Kohno, Eisuke Okugawa, Tomoha Ohsima, Yuta Kondo, Kyoko Okumura, Takana Kamei, Tempei Sato, Hiroshi Asahara, Hitomi Tsuiji, Masaki Fukata, Mitsuharu Hattori
Organizer
第40回 日本神経科学大会
Related Report
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[Presentation] To clarify how Reelin affects the lipid compositions of neurons2017
Author(s)
Katsunari Korogi, Tomoharu Mizukami, Chunyu Zhou, Takao Kohno, Fumiyoshi Yamazaki, Katsuya Kabashima, Yuta Shimanaka, Kazutaka Ikeda, Hiroyuki Arai, Makoto Arita, Mitsutoshi Setou, Mitsuharu Hattori
Organizer
ConBio2017
Related Report
