The potential of non-germ cells to undergo ectopic meiosis and the pathophysiology associated with this potential
| Project/Area Number |
17K19532
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical structure and function and related fields
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| Research Institution | Saitama Medical University |
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Principal Investigator |
Suzuki Ayumu 埼玉医科大学, 医学部, 講師 (80639708)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 減数分裂 / Max / 体細胞 / 生殖細胞 / がん |
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| Outline of Final Research Achievements |
In mammals, it has been thought that meiosis occurs only in germ cells and never in somatic cells. However, we found that repressing the expression of the Max gene induced a meiosis that should not occur in ES cells, even though they are not germ cells. In the present study, we used Max knockout mice to determine whether non-germ cells have the potential to initiate meiosis. We found that some meiotic genes and cancer testis antigen were up-regulated after MAX ablation in some somatic tissues.
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| Academic Significance and Societal Importance of the Research Achievements |
MAXの遺伝子に変異があることにより悪性化するガンは多数報告されているものの、それらの悪性化と減数分裂の関係は知られていない。またMAX遺伝子が欠失したマウスは妊娠初期で流産してしまう。本研究課題は、非生殖細胞における異所性の減数分裂を中心課題に据えたものであるが、減数分裂を起こす潜在能力を規定している分子基盤を解明することは、ガンや流産の発生原因の一端の解明が期待される。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Identification of the coiled-coil domain as an essential Mbd3 element for preserving lineage commitment potential of embryonic stem cells2018
Author(s)
Masataka Hirasaki, Atsushi Ueda, Masamitsu N. Asaka, Kousuke Uranishi, Ayumu Suzuki, Masakazu Kohda, Yosuke Mizuno, Yasushi Okazaki, Masazumi Nishimoto, Jafar Sharif, Haruhiko Koseki, Akihiko Okuda
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Journal Title
Stem Cells
Volume: 印刷中
Issue: 9
Pages: 1355-1367
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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