| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Intracerebral inoculation of hamster-adapted prions into the brain of mice lacking the cellular prion protein (PrPc) results in non-inflammatory brain lesions. In this study we investigated how this phenomenon is associated with prions, and we reconsidered the pathogenesis of prion disease. The brain homogenate of PrPc-deficient mice infected with hamster-adapted prions was inoculated into the brain of new PrPc-deficient mice, and the mice were observed for about 3 years. The results indicated that there was neither neurodegeneration nor abnormal protein deposition in the brain. Thus, hamster-adapted prions themselves caused damage in the brain of PrPc-deficient mice, but their pathogenicity did not propagate without PrPc. These findings suggest that pathogenicity can be separated from prion transmission; PrPc is required for the transmission of prions, but there is a PrPc-free pathway in the pathogenesis of prions.
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