Study on innate immune cells function of mice born from mice receiving virus infection during pregnancy
| Project/Area Number |
17K19559
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathology, Infection/Immunology, and related fields
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
KAWAI Taro 奈良先端科学技術大学院大学, 先端科学技術研究科, 教授 (50456935)
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 自然免疫 / 炎症 / マクロファージ / サイトカイン / 遺伝子発現 / シグナル伝達 / 樹状細胞 / 免疫寛容 / LPS / ウイルス感染 |
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| Outline of Final Research Achievements |
It has been suggested that innate immune cells have a capacity to change their responsibility to the second infection, depending on the initial infection they received. In this study, we investigated the effect of the initial infection during embryo on their innate immune quality after birth. We found that innate immune cells of mice born from pregnant mice receiving viral RNA showed decreased production of inflammatory cytokines during bacterial LPS exposure and showed innate immune tolerance. This suggests that the innate immune cells function is established during embryo. In addition, we also found that Tet methylcytosine deoxygenate 1 (TET1) and a component vacuolar ATPase are required for negative regulation of LPS-induced cytokine induction, suggesting that these proteins play important roles in mediating innate immune tolerance.
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| Academic Significance and Societal Importance of the Research Achievements |
自然免疫系の破綻はがん、自己免疫疾患、アレルギー等様々な疾患を誘導することが知られている。本研究は、マウスにおいて妊娠期にウイルスRNAに暴露された母マウスから生まれた仔マウスの自然免疫細胞の活性化が低下しており一種の免疫寛容を呈している可能性を示した。このことから、自然免疫細胞の機能は胎児期にある程度規定されていることが示唆された。このことは、自然免疫系が関与する疾患において、胎児期での感染暴露経験がその後の疾患発症に関連している可能性があることから、本研究成果は、免疫系の成立機構を理解する学術的意義に加え、疾患治療や診断において社会的意義があると考えられる。
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.2017
Author(s)
Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T
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Journal Title
Proc Natl Acad Sci U S A
Volume: 114
Issue: 10
Pages: 2681-2686
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Book] 血液内科2017
Author(s)
奥出遥奈、中川実優、川崎拓実、河合太郎
Total Pages
7
Publisher
科学評論社
Related Report
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