B-cell mediated pathogenesis of allergic diseases
| Project/Area Number |
17K19573
|
|---|
| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathology, Infection/Immunology, and related fields
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
Haniuda Kei 東京理科大学, 研究推進機構生命医科学研究所, 講師 (40734918)
|
|---|
| Project Period (FY) |
2017-06-30 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|
|---|
| Keywords | IgE / B細胞 / アレルギー / 免疫記憶 / 抗体 / 免疫学 |
|---|
| Outline of Final Research Achievements |
IgE antibody is known as a cause and an exacerbating factor for allergic diseases. The membrane IgE, expressed on the surface of IgE+ B cells, autonomously transduces BCR-signaling and suppresses IgE-type memory formation by inducing short-lived plasma cell differentiation of IgE+ B cells. The aim of this study was the elucidation of the mechanism that induces spontaneous IgE-signaling and suppresses longevity of B cells. We identified a receptor that binds to the extracellular domain of membrane IgE and induces autonomous signaling. We also revealed that membrane IgE drives plasma cell differentiation through metabolic reprogramming of B cells.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究により、短命の形質細胞へと分化して一過性に抗体産生を誘導するが免疫記憶を形成しないというIgE＋B細胞の特性は、膜型IgEによる自発的シグナルの形成と、その結果誘導されるB細胞内の代謝リプログラミングによって規定されることが判明した。このB細胞内因的なメカニズムにより、過剰産生によりアレルギー疾患発症の原因となるIgE抗体の産生が制御されていることが明らかとなった。したがって、IgE高値を示すアレルギー疾患患者では、何らかの要因により膜型IgEの自発的シグナルの形成異常やIgE＋B細胞の代謝プログラムが変化している可能性が予想される。
|
Report
(3 results)
Research Products
(24 results)
-
-
-
[Journal Article] IL-9 receptor signaling in memory B cells regulates humoral recall responses.2018
Author(s)
Takatsuka, S., Yamada, H., Haniuda, K., Saruwatari, H., Ichihashi, M., Renauld, J.-C. and Kitamura, D.
-
Journal Title
Nature Immunology
Volume: 19
Issue: 9
Pages: 1025-1034
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
