| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Although cancer tissues are composed of heterogeneous tumor cell populations, it is still poorly understood how distinct tumor cells contribute to cancer progression. In this situation, I found that two MDCK cells activating oncogenic Ras and Src cause cell fusion when they coexisted. This result suggests that distinct tumor cells drives cancer cell evolution via cell-cell interaction. In this project, I aimed to dissect the mechanism by which Ras and Src cells developed into newly generated tumor cells via cell fusion. I found that Src cells cause cellular hypertrophy of Ras cells via cell-cell interaction. Interestingly, hypertrophic Ras cells have capability of cell fusion and behave as the leader cell in collective cell migration. Furthermore, I found that Src cells secrete glutamate in extracellular space to cause cellular hypertrophy of Ras cells. These findings suggest that Src-activating cells provide additive function to Ras-activating cells for tumor progression.
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