| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We investigated the relationship between bacterial growth in tumors and cancer microenvironmental remodeling, while analyzing the NO-producing ability of mutants of genes involved in NO production. We also developed a novel labeling method of bacteria to evaluate their biodistribution in the body with positron emission tomography. An attenuated strain of Salmonella that successfully grew and functioned in tumors close to human clinical practice induced cancer microenvironmental remodeling, including massive necrosis. It was suggested that the strain may exert unique actions other than increasing tumor vascular permeability.
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