• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Do mitochondrially encoded peptides function as strain identity chemosignals in mice?

Research Project

Project/Area Number 17K19635
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Brain sciences and related fields
Research InstitutionKochi University

Principal Investigator

KABA Hideto  高知大学, 医学部, 特任教授 (50136371)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords嗅覚コミュニケーション / ミトコンドリア由来ペプチド / ブルース効果 / 個体認識 / 鋤鼻系 / 神経科学 / 環境生理学 / 匂い
Outline of Final Research Achievements

In this study I demonstrate (1) the pregnancy block effect on BALB/c mice by NZB mice, which differ from H-2d-compatible BALB/c mice by a single amino acid substitution in mitochondrially encoded peptides, i.e., the nine N-terminal amino acids of NADH dehydrogenases 1 and 2, (2) the unfamiliar (non-self) variants of non-formylated, but not N-formylated, ND1 and ND2 peptides induced pregnancy block and (3) the pregnancy block by an unfamiliar peptide derived from a male of a different strain was prevented by a memory formed at the time of mating with the male. These findings suggest that the mitochondrial peptides are naturally released from a mouse and can form part of the suite of cues for the recognition of strain differences. Such mitochondrial peptides that can signal individual information may be of importance in other vertebrate species and behavioral contexts.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、嗅覚を介した動物間コミュニケーションの実態解明に大きく寄与すると共に、ミトコンドリアゲノム由来ペプチドが“自己か非自己か”を認識する際の原因となり得ることから、嗅覚系と免疫系との新たなクロストークの場を提供し、MHCによる体臭の違いがヒトの配偶者選択に影響を及ぼすように、ヒトにおける嗅覚コミュニケーションの新たな発見にも繋がり得る。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Olfactory Stimulation with Japanese Soy Sauce Improves Upper Limb Performance.2019

    • Author(s)
      Yano Y, Murata Y, Taniguchi M, Okutani F, Yamaguchi M, and Kaba H
    • Journal Title

      Occupational Therapy International

      Volume: 2019 Pages: 1-4

    • DOI

      10.1155/2019/2748721

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Representations of microgeometric tactile information during object recognition.2019

    • Author(s)
      Yasaka K, Mori T, Yamaguchi M, Kaba H.
    • Journal Title

      Cognitive Processing

      Volume: 20 Issue: 1 Pages: 19-30

    • DOI

      10.1007/s10339-018-0892-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] α2-Adrenergic receptor activation promotes long-term potentiation at excitatory synapses in the mouse accessory olfactory bulb.2018

    • Author(s)
      Huang GZ, Taniguchi M, Zhou YB, Zhang JJ, Okutani F, Murata Y, Yamaguchi M, Kaba H.
    • Journal Title

      Learning & Memory

      Volume: 25 Issue: 4 Pages: 147-157

    • DOI

      10.1101/lm.046391.117

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Defective imitation of finger configurations in patients with damage in the right or left hemispheres: An integration disorder of visual and somatosensory information?2017

    • Author(s)
      Okita M, Yukihiro T, Miyamoto K, Morioka S, Kaba H
    • Journal Title

      Brain and Cognition

      Volume: 113 Pages: 109-116

    • DOI

      10.1016/j.bandc.2017.01.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Perception of active head rotation in patients with severe left unilateral spatial neglect.2017

    • Author(s)
      Kaibe S, Okita M, Kaba H.
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 39 Pages: 41-45

    • DOI

      10.1016/j.jocn.2017.01.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス副嗅球樹状突起間抑制性シナプス伝達のバゾプレッシンによる制御:GABAに対する僧帽細胞応答の修飾2019

    • Author(s)
      谷口睦男、村田芳博、山口正洋、椛秀人
    • Organizer
      日本味と匂学会 第53回大会(高知県・高知市)
    • Related Report
      2019 Annual Research Report
  • [Presentation] A role for vasopressin in dendrodendritic inhibition in the mouse accessory olfactory bulb: effects on the mitral cell responses to GABA.2018

    • Author(s)
      Taniguchi M, Murata Y, Yamaguchi M, Kaba H
    • Organizer
      日本味と匂学会第52回大会(埼玉県・さいたま市)
    • Related Report
      2018 Research-status Report
  • [Presentation] A mechanism of action of vasopressin V1a receptors on the recurrent inhibition between mitral cells and granule cells in the mouse accessory olfactory bulb2018

    • Author(s)
      Taniguchi M, Murata Y, Yamaguchi M, Kaba H
    • Organizer
      第95回日本生理学会(香川県・高松市)
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi