exploratory research of gut microbiota-derived metabolites

• Project/Area Number: 17K19673
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Organ-based internal medicine and related fields
• Research Institution: Nagoya University (2018); The University of Tokyo (2017)
• Principal Investigator: Fujishiro Mitsuhiro 名古屋大学, 医学系研究科, 教授 (70396745)
• Co-Investigator(Kenkyū-buntansha): 池田 祐一 東京大学, 医学部附属病院, 特任准教授 (10744419) ; 熊谷 英敏 東京大学, 医学部附属病院, 特任助教 (20281008) ; 山下 裕玄 東京大学, 医学部附属病院, 講師 (50599397) ; 浅岡 良成 東京大学, 医学部附属病院, 助教 (90431858)
• Project Period (FY): 2017-06-30 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 常在性腸内細菌叢 / 新規生理活性代謝産物 / Gタンパク質共役型受容体 / 腸管イントラネット / 生理活性

Outline of Final Research Achievements

In the gastrointestinal tract, there are 100 trillion bactreria, which produce variety of metabolites. We hypothesized that the metabolites would act as the ligands of GPCRs and influence on the physiological functions of the human host and tried to elucidate the novel GPCR ligands from the section of low molecular weight metabolites in the fecus and endoscopy-derived extacts.According to the research, we innovated better novel GPCR assay system than β-arrestin assay, which could detect about 95% of ligand activity in almost all known human GPCRs (about 200).

Academic Significance and Societal Importance of the Research Achievements

β-arrestinアッセイ系より優れた新規GPCRアッセイ系の開発は、リガンド既知のヒトGPCRの全て（約200種類）のおよそ95%の受容体において良好なリガンド活性の検出を可能とし、この新規GPCRアッセイ系を用いれば、リガンド既知のヒトGPCRの全てを単一アッセイフォーマットによりスクリーニングすることが可能となり、新規低分子GPCRリガンドの同定できる可能性が高まった。

Research Products

• [Journal Article] Application of convolutional neural networks for evaluating Helicobacter pylori infection status on the basis of endoscopic images (2019)
  • Author(s): Shichijo Satoki、Endo Yuma、Aoyama Kazuharu、Takeuchi Yoshinori、Ozawa Tsuyoshi、Takiyama Hirotoshi、Matsuo Keigo、Fujishiro Mitsuhiro、Ishihara Soichiro、Ishihara Ryu、Tada Tomohiro
  • Journal Title: Scandinavian Journal of Gastroenterology Volume: 17 Issue: 2 Pages: 1-6
  • DOI: 10.1080/00365521.2019.1577486
  • Peer Reviewed
• [Journal Article] Analysis of predictive factors for R0 resection and immediate bleeding of cold snare polypectomy in colonoscopy (2019)
  • Author(s): Aoki Tomonori、Yoshida Shuntaro、Abe Hiroyuki、Ono Satoshi、Nakada Ayako、Ota Yumiko、Narita Akiko、Yoshikawa Takeshi、Kinoshita Hiroto、Tsuji Yosuke、Yamada Atsuo、Fujishiro Mitsuhiro、Hirata Yoshihiro、Fukayama Masashi、Koike Kazuhiko
  • Journal Title: PLOS ONE Volume: 14 Issue: 3 Pages: e0213281-e0213281
  • DOI: 10.1371/journal.pone.0213281
  • Peer Reviewed / Open Access
• [Journal Article] Automatic detection of erosions and ulcerations in wireless capsule endoscopy images based on a deep convolutional neural network (2019)
  • Author(s): Aoki Tomonori、Yamada Atsuo、Aoyama Kazuharu、Saito Hiroaki、Tsuboi Akiyoshi、Nakada Ayako、Niikura Ryota、Fujishiro Mitsuhiro、Oka Shiro、Ishihara Soichiro、Matsuda Tomoki、Tanaka Shinji、Koike Kazuhiko、Tada Tomohiro
  • Journal Title: Gastrointestinal Endoscopy Volume: 89 Issue: 2 Pages: 357-363.e2
  • DOI: 10.1016/j.gie.2018.10.027
  • Peer Reviewed
• [Journal Article] Novel computer-assisted diagnosis system for endoscopic disease activity in patients with ulcerative colitis (2019)
  • Author(s): Ozawa Tsuyoshi、Ishihara Soichiro、Fujishiro Mitsuhiro、Saito Hiroaki、Kumagai Youichi、Shichijo Satoki、Aoyama Kazuharu、Tada Tomohiro
  • Journal Title: Gastrointestinal Endoscopy Volume: 89 Issue: 2 Pages: 416-421.e1
  • DOI: 10.1016/j.gie.2018.10.020
  • Peer Reviewed
• [Journal Article] Diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks (2019)
  • Author(s): Horie Yoshimasa、Yoshio Toshiyuki、Aoyama Kazuharu、Yoshimizu Shoichi、Horiuchi Yusuke、Ishiyama Akiyoshi、Hirasawa Toshiaki、Tsuchida Tomohiro、Ozawa Tsuyoshi、Ishihara Soichiro、Kumagai Youichi、Fujishiro Mitsuhiro、Maetani Iruru、Fujisaki Junko、Tada Tomohiro
  • Journal Title: Gastrointestinal Endoscopy Volume: 89 Issue: 1 Pages: 25-32
  • DOI: 10.1016/j.gie.2018.07.037
  • Peer Reviewed
• [Journal Article] Identification of marker genes and pathways specific to precancerous duodenal adenomas and early stage adenocarcinomas (2019)
  • Author(s): Sakaguchi Yoshiki、Yamamichi Nobutake、Tomida Shuta、Takeuchi Chihiro、Kageyama-Yahara Natsuko、Takahashi Yu、Shiogama Kazuya、Inada Ken-ichi、Ichinose Masao、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Journal of Gastroenterology Volume: 54 Issue: 2 Pages: 131-140
  • DOI: 10.1007/s00535-018-1489-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy of Vonoprazan for Gastroesophageal Reflux Symptoms in Patients with Proton Pump Inhibitor-resistant Non-erosive Reflux Disease (2018)
  • Author(s): Niikura Ryota、Yamada Atsuo、Hirata Yoshihiro、Hayakawa Yoku、Takahashi Akihiro、Shinozaki Tomohiro、Takeuchi Yoshinori、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Internal Medicine Volume: 57 Issue: 17 Pages: 2443-2450
  • DOI: 10.2169/internalmedicine.0492-17
  • NAID: 130007480036
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-09-01
  • Peer Reviewed
• [Journal Article] A Novel Bioabsorbable Sheet That Delivers NF-κB Decoy Oligonucleotide Restrains Abdominal Aortic Aneurysm Development in Rats (2018)
  • Author(s): Akimoto Shouta、Suzuki Jun-ichi、Aoyama Norio、Ikeuchi Ryota、Watanabe Hajime、Tsujimoto Hiroyuki、Wakayama Kouji、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei
  • Journal Title: International Heart Journal Volume: 59 Issue: 5 Pages: 1134-1141
  • DOI: 10.1536/ihj.17-632
  • NAID: 130007490504
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-09-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Low density neutrophils (LDN) in postoperative abdominal cavity assist the peritoneal recurrence through the production of neutrophil extracellular traps (NETs) (2018)
  • Author(s): Kanamaru Rihito、Ohzawa Hideyuki、Miyato Hideyo、Matsumoto Shiro、Haruta Hidenori、Kurashina Kentaro、Saito Shin、Hosoya Yoshinori、Yamaguchi Hironori、Yamashita Hiroharu、Seto Yasuyuki、Lefor Alan Kawarai、Sata Naohiro、Kitayama Joji
  • Journal Title: Sci Rep. Volume: 8 Issue: 1 Pages: 632-632
  • DOI: 10.1038/s41598-017-19091-2
  • Peer Reviewed / Open Access
• [Journal Article] Non-linear association between long-term outcome and preoperative neutrophil-to-lymphocyte ratio in patients undergoing curative resection for gastric cancer: a retrospective analysis of 1335 cases in a tetrachotomous manner (2018)
  • Author(s): Urabe Masayuki、Yamashita Hiroharu、Uemura Yukari、Tanabe Asami、Yagi Koichi、Aikou Susumu、Seto Yasuyuki
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 48 Issue: 4 Pages: 343-349
  • DOI: 10.1093/jjco/hyy005
  • Peer Reviewed / Open Access
• [Journal Article] Quality of life after robot-assisted transmediastinal radical surgery for esophageal cancer (2018)
  • Author(s): Yoshimura Shuntaro、Mori Kazuhiko、Yamagata Yukinori、Aikou Susumu、Yagi Koichi、Nishida Masato、Yamashita Hiroharu、Nomura Sachiyo、Seto Yasuyuki
  • Journal Title: Surgical Endoscopy Volume: 32 Issue: 5 Pages: 2249-2254
  • DOI: 10.1007/s00464-017-5918-x
  • Peer Reviewed / Open Access
• [Journal Article] CD47 expression in Epstein-Barr virus-associated gastric carcinoma: coexistence with tumor immunity lowering the ratio of CD8+/Foxp3+ T cells (2018)
  • Author(s): Abe Hiroyuki、Saito Ruri、Ichimura Takashi、Iwasaki Akiko、Yamazawa Sho、Shinozaki-Ushiku Aya、Morikawa Teppei、Ushiku Tetsuo、Yamashita Hiroharu、Seto Yasuyuki、Fukayama Masashi
  • Journal Title: Virchows archiv Volume: 印刷中 Issue: 4 Pages: 643-651
  • DOI: 10.1007/s00428-018-2332-2
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection in subjects negative for high titer serum antibody. (2018)
  • Author(s): Toyoshima, O., Nishizawa, T., Arita, M., Kataoka, Y., Sakitani, K., Yoshida, S., Yamashita, H., Hata, K., Watanabe, H., Suzuki, H.
  • Journal Title: World J. Gastroenterol Volume: 24 Issue: 13 Pages: 1419-1428
  • DOI: 10.3748/wjg.v24.i13.1419
  • Peer Reviewed / Open Access
• [Journal Article] Non-exposed endoscopic wall-inversion surgery for gastrointestinal stromal tumor (2018)
  • Author(s): Mitsui Takashi、Yamashita Hiroharu、Aikou Susumu、Niimi Keiko、Fujishiro Mitsuhiro、Seto Yasuyuki
  • Journal Title: Translational Gastroenterology and Hepatology Volume: 3 Pages: 17-17
  • DOI: 10.21037/tgh.2018.03.02
  • Peer Reviewed / Open Access
• [Journal Article] Reevaluation of laparoscopic versus open distal gastrectomy for early gastric cancer in Asia: A meta-analysis of randomized controlled trials (2018)
  • Author(s): Zhang Chun-Dong、Yamashita Hiroharu、Zhang Shun、Seto Yasuyuki
  • Journal Title: International Journal of Surgery Volume: 56 Pages: 31-43
  • DOI: 10.1016/j.ijsu.2018.05.733
  • Peer Reviewed
• [Journal Article] Adenocarcinoma of the esophagogastric junction and its background mucosal pathology: A comparative analysis according to Siewert classification in a Japanese cohort (2018)
  • Author(s): Urabe Masayuki、Ushiku Tetsuo、Shinozaki-Ushiku Aya、Iwasaki Akiko、Yamazawa Sho、Yamashita Hiroharu、Seto Yasuyuki、Fukayama Masashi
  • Journal Title: Cancer Medicine Volume: 7 Issue: 10 Pages: 5145-5154
  • DOI: 10.1002/cam4.1763
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Analysis of Changes to Meibomian Gland Morphology Due to S-1 Chemotherapy (2018)
  • Author(s): Ohtomo Kazuyoshi、Arita Reiko、Shirakawa Rika、Usui Tomohiko、Yamashita Hiroharu、Seto Yasuyuki、Yamagami Satoru、for the TS-1 Multicenter Study Group
  • Journal Title: Translational Vision Science & Technology Volume: 7 Issue: 6 Pages: 37-37
  • DOI: 10.1167/tvst.7.6.37
  • Peer Reviewed / Open Access
• [Journal Article] Status of Helicobacter pylori infection and gastric mucosal atrophy in patients with gastric cancer: Analysis based on the Japan Endoscopy Database (2018)
  • Author(s): Oda Ichiro、Hoteya Shu、Fujishiro Mitsuhiro
  • Journal Title: Digestive Endoscopy Volume: 31 Issue: 1 Pages: 103-103
  • DOI: 10.1111/den.13287
  • Peer Reviewed / Open Access
• [Journal Article] Transduced caudal-type homeobox (CDX) 2/CDX1 can induce growth inhibition on CDX-deficient gastric cancer by rapid intestinal differentiation (2018)
  • Author(s): Nakayama Chiemi、Yamamichi Nobutake、Tomida Shuta、Takahashi Yu、Kageyama-Yahara Natsuko、Sakurai Kouhei、Takeuchi Chihiro、Inada Ken-ichi、Shiogama Kazuya、Nagae Genta、Ono Satoshi、Tsuji Yosuke、Niimi Keiko、Fujishiro Mitsuhiro、Aburatani Hiroyuki、Tsutsumi Yutaka、Koike Kazuhiko
  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 3853-3864
  • DOI: 10.1111/cas.13821
  • Peer Reviewed / Open Access
• [Journal Article] Role of warfarin as a predictor of recurrent bleeding after negative small-bowel capsule endoscopy (2018)
  • Author(s): Niikura Ryota、Yamada Atsuo、Hirata Yoshihiro、Hayakawa Yoku、Suzuki Hirobumi、Yamamoto Shinzo、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Gastrointestinal Endoscopy Volume: 88 Issue: 3 Pages: 574-574
  • DOI: 10.1016/j.gie.2018.04.2344
  • Peer Reviewed
• [Journal Article] Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: ‘Real-world evidence’ in Japan (2018)
  • Author(s): Suzuki Haruhisa、Takizawa Kohei、Hirasawa Toshiaki、Takeuchi Yoji、Ishido Kenji、Hoteya Shu、Yano Tomonori、Tanaka Shinji、Endo Masaki、Nakagawa Masahiro、Toyonaga Takashi、Doyama Hisashi、Hirasawa Kingo、Matsuda Mitsuru、Yamamoto Hironori、Fujishiro Mitsuhiro、et al
  • Journal Title: Digestive Endoscopy Volume: 31 Issue: 1 Pages: 30-39
  • DOI: 10.1111/den.13246
  • NAID: 130007731769
  • Peer Reviewed
• [Journal Article] Gastroesophageal Reflux Disease-Related Disorders of Systemic Sclerosis Based on the Analysis of 66 Patients (2018)
  • Author(s): Matsuda Rie、Yamamichi Nobutake、Shimamoto Takeshi、Sumida Hayakazu、Takahashi Yu、et al.
  • Journal Title: Digestion Volume: 98 Issue: 4 Pages: 201-208
  • DOI: 10.1159/000489848
  • Peer Reviewed
• [Journal Article] Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. (2018)
  • Author(s): Minatsuki C, Yamamichi N, Inada KI, Takahashi Y, Sakurai K, Shimamoto T, Tsuji Y, Shiogama K, Kodashima S, Sakaguchi Y, Niimi K, Ono S, Niwa T, Ohata K, Matsuhashi N, Ichinose M, Fujishiro M, Tsutsumi Y, Koike K.
  • Journal Title: Dig Dis Sci. Volume: 10 Issue: 10 Pages: 2617-2625
  • DOI: 10.1007/s10620-018-5179-0
  • Peer Reviewed
• [Journal Article] Preventive measures against stricture after esophageal endoscopic submucosal dissection: Halfway through the journey to the best method (2018)
  • Author(s): Tsuji Yosuke、Sakaguchi Yoshiki、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Digestive Endoscopy Volume: 30 Issue: 5 Pages: 600-601
  • DOI: 10.1111/den.13191
• [Journal Article] Automatic anatomical classification of esophagogastroduodenoscopy images using deep convolutional neural networks (2018)
  • Author(s): Takiyama Hirotoshi、Ozawa Tsuyoshi、Ishihara Soichiro、Fujishiro Mitsuhiro、Shichijo Satoki、Nomura Shuhei、Miura Motoi、Tada Tomohiro
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 7497-7497
  • DOI: 10.1038/s41598-018-25842-6
  • Peer Reviewed / Open Access
• [Journal Article] Non-variceal upper gastrointestinal bleeding (2018)
  • Author(s): Lanas Angel、Dumonceau Jean-Marc、Hunt Richard H.、Fujishiro Mitsuhiro、Scheiman James M.、Gralnek Ian M.、Campbell Helen E.、Rostom Alaa、Villanueva C?ndid、Sung Joseph J. Y.
  • Journal Title: Nature Reviews Disease Primers Volume: 4 Issue: 1 Pages: 18020-18020
  • DOI: 10.1038/nrdp.2018.20
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A multicenter, randomized controlled trial comparing the identification rate of stigmata of recent hemorrhage and rebleeding rate between early and elective colonoscopy in outpatient-onset acute lower gastrointestinal bleeding: study protocol for a randomized controlled trial (2018)
  • Author(s): Niikura R, Nagata N, Yamada A, Doyama H, Shiratori Y, Nishida T, Kiyotoki S, Yada T, Fujita T, Sumiyoshi T, Hasatani K, Mikami T, Honda T, Mabe K, Hara K, Yamamoto K, Takeda M, Takata M, Tanaka M, Shinozaki T, Fujishiro M, Koike K
  • Journal Title: Trials Volume: 19 Issue: 1 Pages: 214-214
  • DOI: 10.1186/s13063-018-2558-y
  • Peer Reviewed / Open Access
• [Journal Article] Sessile serrated adenoma detection rate is correlated with adenoma detection rate (2018)
  • Author(s): Ohki Daisuke、Tsuji Yosuke、Shinozaki Tomohiro、Sakaguchi Yoshiki、Minatsuki Chihiro、Kinoshita Hiroto、Niimi Keiko、Ono Satoshi、Hayakawa Yoku、Yoshida Shuntaro、Yamada Atsuo、Kodashima Shinya、Yamamichi Nobutake、Hirata Yoshihiro、Ushiku Tetsuo、Fujishiro Mitsuhiro、Fukayama Masashi、Koike Kazuhiko
  • Journal Title: World J Gastrointest Oncol Volume: 10 Issue: 3 Pages: 82-90
  • DOI: 10.4251/wjgo.v10.i3.82
  • Peer Reviewed / Open Access
• [Journal Article] Distinct chemopreventive effects of aspirin in diffuse and intestinal-type gastric cancer. (2018)
  • Author(s): Niikura R, Hayakawa Y, Hirata Y, Konishi M, Suzuki N, Ihara S, Yamada A, Ushiku T, Fujishiro M, Fukayama M, Koike K.
  • Journal Title: Cancer Prev Res (Phila) Volume: - Issue: 5 Pages: 279-286
  • DOI: 10.1158/1940-6207.capr-17-0276
  • Peer Reviewed
• [Journal Article] Application of artificial intelligence using a convolutional neural network for detecting gastric cancer in endoscopic images (2018)
  • Author(s): Hirasawa Toshiaki、Aoyama Kazuharu、Tanimoto Tetsuya、Ishihara Soichiro、Shichijo Satoki、Ozawa Tsuyoshi、Ohnishi Tatsuya、Fujishiro Mitsuhiro、Matsuo Keigo、Fujisaki Junko、Tada Tomohiro
  • Journal Title: Gastric Cancer Volume: 21 Issue: 4 Pages: 653-660
  • DOI: 10.1007/s10120-018-0793-2
  • NAID: 40021587821
  • Peer Reviewed
• [Journal Article] Efficacy and safety of twice-daily rabeprazole maintenance therapy for patients with reflux esophagitis refractory to standard once-daily proton pump inhibitor: the Japan-based EXTEND study (2018)
  • Author(s): Kinoshita Yoshikazu、Kato Mototsugu、Fujishiro Mitsuhiro、Masuyama Hironori、Nakata Ryo、Abe Hisanori、Kumagai Shinji、Fukushima Yasushi、Okubo Yoshiumi、Hojo Seiichiro、Kusano Motoyasu
  • Journal Title: Journal of Gastroenterology Volume: 53 Issue: 7 Pages: 834-844
  • DOI: 10.1007/s00535-017-1417-z
  • Peer Reviewed / Open Access
• [Journal Article] Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys?Dietz syndrome or multiple self-healing squamous epithelioma (2018)
  • Author(s): Fujiwara Takayuki、Takeda Norifumi、Hara Hironori、Morita Hiroyuki、Kishihara Jun、Inuzuka Ryo、Yagi Hiroki、Maemura Sonoko、Toko Haruhiro、Harada Mutsuo、Ikeda Yuichi、Kumagai Hidetoshi、Nomura Seitaro、Takimoto Eiki、Akazawa Hiroshi、Ako Junya、Komuro Issei
  • Journal Title: European Journal of Human Genetics Volume: 26 Issue: 8 Pages: 1151-1158
  • DOI: 10.1038/s41431-018-0127-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of Pathogenic FBN1 Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome (2018)
  • Author(s): Takeda N, Inuzuka R, Maemura S, Morita H, Nawata K, Fujita D, Taniguchi Y, Yamauchi H, Yagi H, Kato M, Nishimura H, Hirata Y, Ikeda Y, Kumagai H, Amiya E, Hara H, Fujiwara T, Akazawa H, Suzuki JI, Imai Y, Nagai R, Takamoto S, Hirata Y, Ono M, Komuro I.
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 11 Issue: 6
  • DOI: 10.1161/circgen.117.002058
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury (2018)
  • Author(s): Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.
  • Journal Title: JACC: Basic to Translational Science Volume: 3 Issue: 5 Pages: 639-653
  • DOI: 10.1016/j.jacbts.2018.07.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transparency-enhancing technology allows three-dimensional assessment of gastrointestinal mucosa: A porcine model. (2018)
  • Author(s): Mizutani H, Ono S, Ushiku T, Kudo Y, Ikemura M, Kageyama N, Yamamichi N, Fujishiro M, Someya T, Fukayama M, Koike K, Onodera H.
  • Journal Title: Pathology International Volume: 68 Issue: 2 Pages: 102-108
  • DOI: 10.1111/pin.12627
  • Peer Reviewed
• [Journal Article] Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report (2018)
  • Author(s): Arakawa Keiichi、Hata Keisuke、Yamamoto Yoko、Nishikawa Takeshi、Tanaka Toshiaki、Kiyomatsu Tomomichi、Kawai Kazushige、Nozawa Hiroaki、Yoshida Masafumi、Fukuhara Hiroshi、Fujishiro Mitsuhiro、Morikawa Teppei、Yamasoba Tatsuya、Koike Kazuhiko、Fukayama Masashi、Watanabe Toshiaki
  • Journal Title: BMC Cancer Volume: 18 Issue: 1 Pages: 24-24
  • DOI: 10.1186/s12885-017-3973-2
  • Peer Reviewed
• [Journal Article] Long-term proton pump inhibitor use is a risk factor of gastric cancer after treatment forHelicobacter pylori: a retrospective cohort analysis (2017)
  • Author(s): Niikura Ryota、Hayakawa Yoku、Hirata Yoshihiro、Yamada Atsuo、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Gut Volume: epub Issue: 10 Pages: 1908-1910
  • DOI: 10.1136/gutjnl-2017-315710
  • Peer Reviewed
• [Journal Article] Laparoscopic and endoscopic cooperative surgery for gastrointestinal tumor (2017)
  • Author(s): Niimi Keiko、Ishibashi Rei、Mitsui Takashi、Aikou Susumu、Kodashima Shinya、Yamashita Hiroharu、Yamamichi Nobutake、Hirata Yoshihiro、Fujishiro Mitsuhiro、Seto Yasuyuki、Koike Kazuhiko
  • Journal Title: Ann Transl Med Volume: 5 Issue: 8 Pages: 187-187
  • DOI: 10.21037/atm.2017.03.35
  • Peer Reviewed
• [Journal Article] Evaluation of endoscopic submucosal dissection using a new endosurgical knife DN-D2718B: a first clinical feasibility study. (2017)
  • Author(s): Sakaguchi Y, Tsuji Y, Fujishiro M, Kataoka Y, Saito I, Shichijo S, Minatsuki C, Asada-Hirayama I, Yamaguchi D, Niimi K, Ono S, Kodashima S, Yamamichi N, Koike K.
  • Journal Title: Endosc Int Open. Volume: 5 Issue: 07 Pages: E670-E674
  • DOI: 10.1055/s-0043-111720
  • Peer Reviewed
• [Journal Article] Associations between drugs and small-bowel mucosal bleeding: Multicenter capsule-endoscopy study (2017)
  • Author(s): Niikura Ryota、Yamada Atsuo、Maki Koutarou、Nakamura Masanao、Watabe Hirotsugu、Fujishiro Mitsuhiro、Oka Shiro、Esaki Motohiro、Fujimori Shunji、Nakajima Atsushi、Ohmiya Naoki、Matsumoto Takayuki、Tanaka Shinji、Koike Kazuhiko、Sakamoto Choitsu
  • Journal Title: Dig Endosc Volume: 30 Issue: 1 Pages: 79-89
  • DOI: 10.1111/den.12922
  • NAID: 130007519801
  • Peer Reviewed
• [Journal Article] Proton pump inhibitor therapy did not increase the prevalence of small-bowel injury: A propensity-matched analysis (2017)
  • Author(s): Yamada Atsuo、Niikura Ryota、Maki Koutarou、Nakamura Masanao、Watabe Hirotsugu、Fujishiro Mitsuhiro、Oka Shiro、Fujimori Shunji、Nakajima Atsushi、Ohmiya Naoki、Matsumoto Takayuki、Tanaka Shinji、Koike Kazuhiko、Sakamoto Choitsu
  • Journal Title: PLoS One Volume: 12 Issue: 8 Pages: e0182586-e0182586
  • DOI: 10.1371/journal.pone.0182586
  • Peer Reviewed
• [Journal Article] Design paper: Japan Endoscopy Database (JED): A prospective, large database project related to gastroenterological endoscopy in Japan (2017)
  • Author(s): Matsuda Koji、Tanaka Kiyohito、Fujishiro Mitsuhiro、Saito Yutaka、Ohtsuka Kazuo、Oda Ichiro、Katada Chikatoshi、Kato Masayuki、Kida Mitsuhiro、Kobayashi Kiyonori、Hoteya Shu、Horimatsu Takahiro、Kodashima Shinya、Matsuda Takahisa、Muto Manabu、Yamamoto Hironori、Ryozawa Shomei、Iwakiri Ryuichi、Kutsumi Hiromu、et al
  • Journal Title: Dig Endosc Volume: 30 Issue: 1 Pages: 5-19
  • DOI: 10.1111/den.12964
  • NAID: 130007498917
  • Peer Reviewed
• [Journal Article] First progress report on the Japan Endoscopy Database project (2017)
  • Author(s): Kodashima Shinya、Tanaka Kiyohito、Matsuda Koji、Fujishiro Mitsuhiro、Saito Yutaka、Ohtsuka Kazuo、Oda Ichiro、Katada Chikatoshi、Kato Masayuki、Kida Mitsuhiro、Kobayashi Kiyonori、Hoteya Shu、Horimatsu Takahiro、Matsuda Takahisa、Muto Manabu、Yamamoto Hironori、Ryozawa Shomei、Iwakiri Ryuichi、Kutsumi Hiromu、et al
  • Journal Title: Dig Endosc Volume: 30 Issue: 1 Pages: 20-28
  • DOI: 10.1111/den.12963
  • Peer Reviewed
• [Journal Article] Evaluation of image-enhanced endoscopic technology using advanced diagnostic endoscopy for the detection of early gastric cancer: a pilot study (2017)
  • Author(s): Yamaguchi Daisuke、Kodashima Shinya、Fujishiro Mitsuhiro、Ono Satoshi、Niimi Keiko、Mochizuki Satoshi、Tsuji Yosuke、Asada-Hirayama Itsuko、Sakaguchi Yoshiki、Shichijo Satoki、Minatsuki Chihiro、Yamamichi Nobutake、Koike Kazuhiko
  • Journal Title: Endosc Int Open Volume: 05 Issue: 09 Pages: C2-C2
  • DOI: 10.1055/s-0043-119930
  • Peer Reviewed
• [Journal Article] Is it possible to perform gastric endoscopic submucosal dissection without discontinuation of a single antiplatelet of thienopyridine derivatives? (2017)
  • Author(s): Ono Satoshi、Myojo Masahiro、Harada Hideaki、Tsuji Kunihiro、Murakami Daisuke、Suehiro Satoshi、Doyama Hisashi、Ando Jiro、Saito Itaru、Fujishiro Mitsuhiro、Komuro Issei、Koike Kazuhiko
  • Journal Title: Endosc Int Open Volume: 05 Issue: 09 Pages: E943-E949
  • DOI: 10.1055/s-0043-116381
  • Peer Reviewed
• [Journal Article] Colonoscopy reduces colorectal cancer mortality: A multicenter, long-term, colonoscopy-based cohort study (2017)
  • Author(s): Niikura Ryota、Hirata Yoshihiro、Suzuki Nobumi、Yamada Atsuo、Hayakawa Yoku、Suzuki Hirobumi、Yamamoto Shinzo、Nakata Ryo、Komatsu Junko、Okamoto Makoto、Kodaira Makoto、Shinozaki Tomohiro、Fujishiro Mitsuhiro、Watanabe Toshiaki、Koike Kazuhiko
  • Journal Title: PLoS One Volume: 12 Issue: 9 Pages: e0185294-e0185294
  • DOI: 10.1371/journal.pone.0185294
  • Peer Reviewed
• [Journal Article] Recent Development of Techniques and Devices in Colorectal Endoscopic Submucosal Dissection (2017)
  • Author(s): Mizutani Hiroya、Ono Satoshi、Ohki Daisuke、Takeuchi Chihiro、Yakabi Seiichi、Kataoka Yosuke、Saito Itaru、Sakaguchi Yoshiki、Minatsuki Chihiro、Tsuji Yosuke、Niimi Keiko、Kodashima Shinya、Yamamichi Nobutake、Fujishiro Mitsuhiro、Koike Kazuhiko
  • Journal Title: Clin Endosc Volume: 50 Issue: 6 Pages: 562-568
  • DOI: 10.5946/ce.2017.108
  • Peer Reviewed
• [Journal Article] Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma. (2017)
  • Author(s): Yamazawa S, Ushiku T, Shinozaki-Ushiku A, Hayashi A, Iwasaki A, Abe H, Tagashira A, Yamashita H, Seto Y, Aburatani H, Fukayama M.
  • Journal Title: Am J Surg Pathol. Volume: 41 Pages: 989-997
  • Peer Reviewed
• [Journal Article] Lymphogenous metastasis to the transverse colon that originated from signet-ring cell gastric cancer: A case report and review of the literature (2017)
  • Author(s): Sonoda Hirofumi、Kawai Kazushige、Yamaguchi Hironori、Murono Koji、Kaneko Manabu、Nishikawa Takeshi、Otani Kensuke、Sasaki Kazuhito、Yasuda Koji、Tanaka Toshiaki、Kiyomatsu Tomomichi、Hata Keisuke、Nozawa Hiroaki、Ishihara Soichiro、Aikou Susumu、Yamashita Hiroharu、et al.
  • Journal Title: Clin Res Hepatol Gastroenterol. Volume: 41 Issue: 6 Pages: e81-e86
  • DOI: 10.1016/j.clinre.2017.04.002
  • Peer Reviewed
• [Journal Article] Results of a nationwide questionnaire-based survey on nutrition management following gastric cancer resection in Japan (2017)
  • Author(s): Shimizu Nobuyuki、Hatao Fumihiko、Fukatsu Kazuhiko、Aikou Susumu、Yamagata Yukinori、Mori Kazuhiko、Yamashita Hiroharu、Nomura Sachiyo、Seto Yasuyuki
  • Journal Title: Surg Today. Volume: 47 Issue: 12 Pages: 1460-1468
  • DOI: 10.1007/s00595-017-1552-4
  • Peer Reviewed
• [Journal Article] Reply to: LODDS or negative to positive lymph nodes ratio? (2017)
  • Author(s): Yamashita Hiroharu、Deng Jingyu、Liang Han、Seto Yasuyuki
  • Journal Title: Surgery. Volume: 162 Issue: 5 Pages: 1190-1191
  • DOI: 10.1016/j.surg.2017.05.002
  • Peer Reviewed
• [Journal Article] Numeric pathologic lymph node classification shows prognostic superiority to topographic pN classification in esophageal squamous cell carcinoma (2017)
  • Author(s): Sugawara Kotaro、Yamashita Hiroharu、Uemura Yukari、Mitsui Takashi、Yagi Koichi、Nishida Masato、Aikou Susumu、Mori Kazuhiko、Nomura Sachiyo、Seto Yasuyuki
  • Journal Title: Surgery. Volume: 162 Issue: 4 Pages: 846-856
  • DOI: 10.1016/j.surg.2017.06.013
  • Peer Reviewed
• [Journal Article] Comparison of Prognostic Abilities Among Preoperative Laboratory Data Indices in Patients with Resectable Gastric and Esophagogastric Junction Adenocarcinoma (2017)
  • Author(s): Urabe Masayuki、Yamashita Hiroharu、Watanabe Toshiaki、Seto Yasuyuki
  • Journal Title: World J Surg. Volume: 42 Issue: 1 Pages: 185-194
  • DOI: 10.1007/s00268-017-4146-9
  • Peer Reviewed
• [Journal Article] A surgical case of radiotherapy induced esophageal perforation accompanying pyogenic spondylodiscitis: a case report (2017)
  • Author(s): Yoshimura Shuntaro、Mori Kazuhiko、Kawasaki Koichiro、Tanabe Asami、Aikou Susumu、Yagi Koichi、Nishida Masato、Yamashita Hiroharu、Nomura Sachiyo、Fukushima Masayoshi、Yamashita Hideomi、Yamauchi Yasuhiro、Seto Yasuyuki
  • Journal Title: Surgical Case Reports Volume: 3 Issue: 1 Pages: 1-5
  • DOI: 10.1186/s40792-017-0368-1
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility of Laparoscopic Gastrectomy for Elderly Gastric Cancer Patients: Meta-analysis of Non-Randomised Controlled Studies. (2017)
  • Author(s): Zong L, Deng J, Wang J, Wu A, Wang J, Sun Z, Maeda M, Abe M, Wang W, Jiang Z, Seto Y and Ji J.
  • Journal Title: Oncotarget8(31):51878-51887 Volume: 8(31) Issue: 31 Pages: 51878-51887
  • DOI: 10.18632/oncotarget.16691
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decrease in <i>PSCA</i> expression caused by <i>Helicobacter pylori</i> infection may promote progression to severe gastritis (2017)
  • Author(s): Toyoshima Osamu、Tanikawa Chizu、Yamamoto Ryuta、Watanabe Hidenobu、Yamashita Hiroharu、Sakitani Kosuke、Yoshida Shuntaro、Kubo Michiaki、Matsuo Keitaro、Ito Hidemi、Koike Kazuhiko、Seto Yasuyuki、Matsuda Koichi
  • Journal Title: Oncotarget. Volume: 9 Issue: 3 Pages: 3936-3945
  • DOI: 10.18632/oncotarget.23278
  • Peer Reviewed / Open Access
• [Journal Article] Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia. (2017)
  • Author(s): Aoyama N, Suzuki J, Kobayashi N, Hanatani T, Ashigaki A, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Minabe M, Izumi Y, Isobe M.
  • Journal Title: BMC Cardiovasc Disord. Volume: 17 Pages: 267-267
  • Peer Reviewed
• [Journal Article] Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients (2017)
  • Author(s): Aoyama Norio、Suzuki Jun-ichi、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
  • Journal Title: Heart Vessels. Volume: 33 Issue: 2 Pages: 198-204
  • DOI: 10.1007/s00380-017-1042-z
  • Peer Reviewed
• [Journal Article] Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation (2017)
  • Author(s): Aoyama N, Suzuki JI, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, Sato H, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Izumi Y, Isobe M
  • Journal Title: Heart Vessels Volume: 32 Issue: 11 Pages: 1314-1319
  • DOI: 10.1007/s00380-017-1003-6
  • Peer Reviewed
• [Journal Article] Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2 (2017)
  • Author(s): Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y
  • Journal Title: PLoS One Volume: 12 Issue: 4 Pages: 0175452-0175452
  • DOI: 10.1371/journal.pone.0175452
  • NAID: 120007129138
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. (2017)
  • Author(s): Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.
  • Journal Title: PLoS One. Volume: 12 Issue: 3 Pages: 0174099-0174099
  • DOI: 10.1371/journal.pone.0174099
  • Peer Reviewed / Open Access
• [Journal Article] Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering (2017)
  • Author(s): Takanashi M, Taira Y, Okazaki S, Takase S, Kimura T, Li CC, Xu PF, Noda A, Sakata I, Kumagai H, Ikeda Y, Iizuka Y, Yahagi N, Shimano H, Osuga JI, Ishibashi S, Kadowaki T, Okazaki H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 11 Pages: 1105-1116
  • DOI: 10.5551/jat.39552
  • NAID: 130006191603
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction. (2017)
  • Author(s): Watanabe R, Suzuki JI, Wakayama K, Maejima Y, Shimamura M, Koriyama H, Nakagami H, Kumagai H, Ikeda Y, Akazawa H, Morishita R, Komuro I, Isobe M.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 43920-43920
  • DOI: 10.1038/srep43920
  • Peer Reviewed / Open Access
• [Journal Article] A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice (2017)
  • Author(s): Sato H, Suzuki JI, Aoyama N, Watanabe R, Kaneko M, Shiheido Y, Yoshida A, Wakayama K, Kumagai H, Ikeda Y, Akazawa H, Komuro I, Isobe M, Izumi Y
  • Journal Title: Hypertens Res. Volume: 40 Issue: 1 Pages: 35-40
  • DOI: 10.1038/hr.2016.114
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Re-evaluating the prognostic validity of the negative to positive lymph node ratio in node-positive gastric cancer patients (2017)
  • Author(s): Yamashita Hiroharu、Deng Jingyu、Liang Han、Seto Yasuyuki
  • Journal Title: Surgery. Volume: 161 Issue: 6 Pages: 1588-1596
  • DOI: 10.1016/j.surg.2016.12.018
  • Peer Reviewed
• [Journal Article] How should we define the no. 3b lesser curvature lymph node? (2017)
  • Author(s): Yamashita Hiroharu、Yagi Koichi、Seto Yasuyuki
  • Journal Title: Gastric Cancer Volume: 20 Issue: 3 Pages: 558-559
  • DOI: 10.1007/s10120-016-0638-9
  • Peer Reviewed
• [Journal Article] Pretreatment Neutrophil to Lymphocyte Ratio Independently Predicts Disease-specific Survival in Patients With Resectable Gastroesophageal Junction and Gastric Cancer (2016)
  • Author(s): M. Urabe, H. Yamashita, Y. Seto
  • Journal Title: Ann Surg Volume: - Issue: 6 Pages: e76-e77
  • DOI: 10.1097/sla.0000000000001596
  • Peer Reviewed