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Energy dynamics defining organ plasticity

Research Project

Project/Area Number 17K19677
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Organ-based internal medicine and related fields
Research InstitutionKyoto University

Principal Investigator

Motoko Yanagita  京都大学, 医学研究科, 教授 (70378769)

Research Collaborator Yamamoto Masamichi  
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords修復 / 代謝 / エネルギー / ATP / 腎臓病
Outline of Final Research Achievements

Acute kidney injury (AKI) model was induced in R26Ateam mice that expressed FRET biosensor (ATeam) to visualize intracellular ATP concentrations systemically, and its ATP dynamics in the kidney was monitored. ATP levels in proximal tubules, the most vulnerable segment in the nephron during AKI, fluctuated after injury, and the fluctuation was correlated with fibrosis after one month. These results indicate that energy dynamics in acute phase is an important indicator of kidney prognosis.

Academic Significance and Societal Importance of the Research Achievements

本研究は、急性期のエネルギー代謝と腎予後を結びつけた点で意義が深い。
急性期のエネルギー代謝を改善することが腎予後を改善するかどうかは今後の検討課題であり、新しい創薬標的としても有望である。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 Other

All Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 7 results) Remarks (1 results)

  • [Journal Article] Myofibroblasts acquire retinoic acid?producing ability during fibroblast-to-myofibroblast transition?following kidney injury2019

    • Author(s)
      Nakamura Jin、Sato Yuki、Kitai Yuichiro、Wajima Shuichi、Yamamoto Shinya、Oguchi Akiko、Yamada Ryo、Kaneko Keiichi、Kondo Makiko、Uchino Eiichiro、Tsuchida Junichi、Hirano Keita、Sharma Kumar、Kohno Kenji、Yanagita Motoko
    • Journal Title

      Kidney International

      Volume: 95 Issue: 3 Pages: 526-539

    • DOI

      10.1016/j.kint.2018.10.017

    • NAID

      120006550402

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 急性腎障害(AKI)と慢性腎臓病(CKD):その移行メカニズム2018

    • Author(s)
      北井悠一朗、柳田素子
    • Journal Title

      日本内科学会雑誌

      Volume: 107 Pages: 1800-1803

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Immune cells and inflammation in AKI to CKD progression2018

    • Author(s)
      Sato Yuki、Yanagita Motoko
    • Journal Title

      American Journal of Physiology-Renal Physiology

      Volume: 315 Issue: 6 Pages: F1501-F1512

    • DOI

      10.1152/ajprenal.00195.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guanylyl cyclase A in both renal proximal tubular and vascular endothelial cells protects the kidney against acute injury in rodent experimental endotoxemia models.2018

    • Author(s)
      Kidney against Acute Injury in Rodent Experimental Endotoxemia Models. Kitamura H, Nakano D, Sawanobori Y, Asaga T, Yokoi H, Yanagita M, Mukoyama M, Tokudome T, Kangawa K, Shirakami G, Nishiyama A.
    • Journal Title

      Anesthesiology

      Volume: 印刷中 Issue: 2 Pages: 296-310

    • DOI

      10.1097/aln.0000000000002214

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis2018

    • Author(s)
      Asao Rin、Seki Takuto、Takagi Miyuki、Yamada Hiroyuki、Kodama Fumiko、Hosoe-Nagai Yoshiko、Tanaka Eriko、Trejo Juan Alejandro Oliva、Yamamoto-Nonaka Kanae、Sasaki Yu、Hidaka Teruo、Ueno Takashi、Yanagita Motoko、Suzuki Yusuke、Tomino Yasuhiko、Asanuma Katsuhiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5061-5061

    • DOI

      10.1038/s41598-018-23278-6

    • NAID

      120006517798

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucocorticoid receptor expression in resident and hematopoietic cells in IgG4-related disease.2018

    • Author(s)
      Iguchi T, Takaori K, Mii A, Sato Y, Suzuki Y, Yoshifuji H, Seno H, Ogawa O, Omori K, Bessho K, Kondo S, Yoshizaki T, Nakashima H, Saito T, Mimori T, Haga H, Kawano M, Yanagita M.
    • Journal Title

      Mod Pathol.

      Volume: - Issue: 6 Pages: 890-899

    • DOI

      10.1038/s41379-018-0036-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] “Resident fibroblasts in the kidney: a major driver of fibrosis and inflammation”2017

    • Author(s)
      Sato Y, Yanagita M.
    • Journal Title

      Inflamm Regen.

      Volume: -

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 拡大する腎臓病学ー基礎研究から実地臨床への展開ー2018

    • Author(s)
      柳田素子
    • Organizer
      第48回日本腎臓学会西部学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Update to EPO-producing cells2018

    • Author(s)
      柳田素子
    • Organizer
      第63回日本透析医学会学術集会・総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 近位尿細管細胞と線維芽細胞のクロストーク:障害、修復と線維化2018

    • Author(s)
      柳田素子
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 急性腎障害の発症と進展のメカニズム2018

    • Author(s)
      柳田素子
    • Organizer
      第61回日本腎臓学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 日常診療における難治性疾患への対応とピットフォール2018

    • Author(s)
      柳田素子
    • Organizer
      第115回日本内科学会講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Epithelial Pericyte Reciprocal Signaling in AKI:Basic/Clinical Science Session2017

    • Author(s)
      Motoko Yanagita
    • Organizer
      American Society of Nephrology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] シンポジウム:老化腎の可塑性低下のメカニズム2017

    • Author(s)
      柳田素子
    • Organizer
      第60回日本腎臓学会学術総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Remarks] 京都大学腎臓内科学

    • URL

      http://www.kidney.kuhp.kyoto-u.ac.jp

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2020-03-30  

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