Development of angiogeneic pancreatic islets using iPS cell-derived pancreatic islet cells
| Project/Area Number |
17K19692
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgery of the organs maintaining homeostasis and related fields
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 膵島移植 / 血管化 / 移植・再生医療 |
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| Outline of Final Research Achievements |
Islet transplantation is a cellular therapy for improving control of blood glucose by transplantation of islets. The major obstacles of the therapy are limited donor supplies and ischemia. In this study, we attempted to develop angiogeneic islets using rodents and using human iPS cell-derived islet cells. We succeeded to develop angiogeneic islets using islets acquired from mice and certified decrease of blood glucose after transplantation of the angiogeneic islets.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、移植する膵島にあらかじめ血管を付帯させる、いわゆる血管化膵島を開発する研究であり、特にiPS細胞由来の膵島細胞を用いた血管化膵島の開発を目指した。結果、マウス膵島からなる血管化膵島の作成と移植実験における有効性という点で一定の成果を挙げることができた。今後、iPS細胞はもちろんのこと、ブタなどの大型動物を利用した血管化膵島を実用化することができれば、膵島移植におけるドナー不足の問題が解決し、多くの重症糖尿病患者がこの治療の恩恵を受けられるようになると期待される。
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Frey's procedure for chronic pancreatitis improves the nutritional status of these patients.2018
Author(s)
Sato H, Ishida M, Motoi F, Sakata N, Aoki T, Kudoh K, Ohtsuka H, Mizuma M, Morikawa T, Hayashi H, Nakagawa K, Naitoh T, Egawa S, Unno M.
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Journal Title
Surg Today
Volume: 48
Issue: 1
Pages: 80-86
DOI
Related Report
Peer Reviewed
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[Journal Article] A long-term survival case treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis2017
Author(s)
Shimura M, Mizuma M, Hayashi H, Mori A, Tachibana T, Hata T, Iseki M, Takadate T, Ariake K, Maeda S, Ohtsuka H, Sakata N, Morikawa T, Nakagawa K, Naitoh T, Kamei T, Motoi F, Unno M.
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Journal Title
Surg Case Rep
Volume: 3
Issue: 1
Pages: 132-132
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The comparative anatomy of the folds, fossas, and adhesions around the duodenojejunal flexure in mammals.2017
Author(s)
Ishida M, Sakata N, Ise I, Ono T, Shimura M, Ishii K, Murakami M, Takadate T, Aoki T, Kudo K, Ohnuma S, Fukase K, Ohtsuka H, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Naitoh T, Unno M.
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Journal Title
Folia Morphol
Volume: -
Issue: 2
Pages: 286-292
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration.2017
Author(s)
Miura T, Tachikawa M, Ohtsuka H, Fukase K, Nakayama S, Sakata N, Motoi F, Naitoh T, Katayose Y, Uchida Y, Ohtsuki S, Terasaki T, Unno M.
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Journal Title
J Pharm Sci
Volume: 106
Issue: 9
Pages: 2499-2508
DOI
Related Report
Peer Reviewed
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