Research Project
Grant-in-Aid for Challenging Research (Exploratory)
Islet transplantation is a cellular therapy for improving control of blood glucose by transplantation of islets. The major obstacles of the therapy are limited donor supplies and ischemia. In this study, we attempted to develop angiogeneic islets using rodents and using human iPS cell-derived islet cells. We succeeded to develop angiogeneic islets using islets acquired from mice and certified decrease of blood glucose after transplantation of the angiogeneic islets.
本研究は、移植する膵島にあらかじめ血管を付帯させる、いわゆる血管化膵島を開発する研究であり、特にiPS細胞由来の膵島細胞を用いた血管化膵島の開発を目指した。結果、マウス膵島からなる血管化膵島の作成と移植実験における有効性という点で一定の成果を挙げることができた。今後、iPS細胞はもちろんのこと、ブタなどの大型動物を利用した血管化膵島を実用化することができれば、膵島移植におけるドナー不足の問題が解決し、多くの重症糖尿病患者がこの治療の恩恵を受けられるようになると期待される。
All 2019 2018 2017 Other
All Journal Article (11 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 11 results, Open Access: 7 results) Presentation (17 results) (of which Int'l Joint Research: 3 results, Invited: 2 results) Remarks (2 results)
Journal of Clinical Medicine
Volume: 8 Issue: 2 Pages: 249-249
10.3390/jcm8020249
Surgery Today
Volume: 49 Issue: 2 Pages: 137-142
10.1007/s00595-018-1720-1
Cancer Science
Volume: 109 Issue: 12 Pages: 3883-3895
10.1111/cas.13829
Volume: 48 Issue: 10 Pages: 916-920
10.1007/s00595-018-1677-0
Oncotarget
Volume: 9 Issue: 36 Pages: 24291-24303
10.18632/oncotarget.25110
Int J Mol Sci
Volume: 19 Issue: 5 Pages: 1391-1391
10.3390/ijms19051391
Surg Today
Volume: 48 Issue: 1 Pages: 80-86
10.1007/s00595-017-1557-z
Surg Case Rep
Volume: 3 Issue: 1 Pages: 132-132
10.1186/s40792-017-0409-9
PLoS One
Volume: 12 Issue: 11 Pages: e0187927-e0187927
10.1371/journal.pone.0187927
120006878515
Folia Morphol
Volume: - Issue: 2 Pages: 286-292
10.5603/fm.a2017.0089
J Pharm Sci
Volume: 106 Issue: 9 Pages: 2499-2508
10.1016/j.xphs.2017.02.018
http://resweb2.jhk.adm.fukuoka-u.ac.jp/FukuokaUnivHtml/info/7263/R108J.html