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Comprehensive analysis of gut microbiome before and after gastroenterological surgery.

Research Project

Project/Area Number 17K19702
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Surgery of the organs maintaining homeostasis and related fields
Research InstitutionKumamoto University

Principal Investigator

BABA Yoshifumi  熊本大学, 医学部附属病院, 特任講師 (20599708)

Co-Investigator(Kenkyū-buntansha) 美馬 浩介  熊本大学, 医学部附属病院, 非常勤診療医師 (00546559)
澤 智裕  熊本大学, 大学院生命科学研究部(医), 教授 (30284756)
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords腸内細菌叢 / 消化器癌 / 胃癌 / 食道癌 / microbiome / 体重変化 / Microbiome / 栄養状態 / Fusobacterium / esophageal cancer / gastric cancer
Outline of Final Research Achievements

The aims of this study are to comprehensively analyze the change of gut microbiome before and after surgical resection in patients with gastrointestinal cancers and to detect the candidate microbiome affecting the body weight loss after surgery. We are collecting feces samples from patients with gastrointestinal cancers with permission of Institutional Review Board. Until now we have collected samples from 30 patients and sequentially submitted to 16S rRNA sequence.
We concurrently constructed the clinical database for evaluating the nutrition status in patients with gastrointestinal cancers. Utilizing this database, we could clarify the relationship between preoperative nutrition status and tumor immunity in gastrointestinal cancers. Nutritional status and systemic immune competence may influence patients’ prognosis through the local immune response. These finding were published in Annals of Surgery.

Academic Significance and Societal Importance of the Research Achievements

食道癌、胃癌に対する治療の中心は、今でもなお“手術”である。これらの手術に際して、食道、胃などの臓器温存は難しく、食事の通り道の再建が必要である。しかし、多くの患者において、栄養状態の低下、体重減少により術後の生活の質(quality of life)が著しく損なわれてしまうため、それらを改善する治療法を開発することは喫緊の課題である。腸内細菌叢Microbiomeは、近年、癌、肥満、炎症性腸疾患、非アルコール性脂肪性肝疾患など様々な疾患との関連が報告され、注目を集めている先端性の高い分野である。消化器癌術後のmicrobiomeの変化に関する研究は皆無であり、本研究は極めて独創的である。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Prognostic Nutritional Index, Tumor-infiltrating Lymphocytes, and Prognosis in Patients with Esophageal Cancer2018

    • Author(s)
      Okadome Kazuo、Baba Yoshifumi、Yagi Taisuke、Kiyozumi Yuki、Ishimoto Takatsugu、Iwatsuki Masaaki、Miyamoto Yuji、Yoshida Naoya、Watanabe Masayuki、Baba Hideo
    • Journal Title

      Annals of Surgery

      Volume: 271 Issue: 4 Pages: 1-1

    • DOI

      10.1097/sla.0000000000002985

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IDO1 Expression Is Associated With Immune Tolerance and Poor Prognosis in Patients With Surgically Resected Esophageal Cancer.2018

    • Author(s)
      Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ishimoto T, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M, Komohara Y, Baba H.
    • Journal Title

      Ann Surg

      Volume: Mar 27 Issue: 6 Pages: 1-1

    • DOI

      10.1097/sla.0000000000002754

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progress in characterizing the linkage between Fusobacterium nucleatum and gastrointestinal cancer2018

    • Author(s)
      Liu Yang、Baba Yoshifumi、Ishimoto Takatsugu、Iwatsuki Masaaki、Hiyoshi Yukiharu、Miyamoto Yuji、Yoshida Naoya、Wu Rong、Baba Hideo
    • Journal Title

      Journal of Gastroenterology

      Volume: 54 Issue: 1 Pages: 33-41

    • DOI

      10.1007/s00535-018-1512-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食道癌におけるLINE-1メチル化と腫瘍免疫2018

    • Author(s)
      馬場祥史、小澄敬祐、岡留一雄、八木泰佑、清住雄希、江藤弘二郎、日吉幸晴、長井洋平、石本崇胤、岩上志朗、宮本裕士、吉田直矢、馬場秀夫
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 腸内細菌 Fusobacterium nucleatumは食道癌に対する化学療法感受性に影響を与える2018

    • Author(s)
      馬場祥史、山村謙介、江藤弘二郎、日吉幸晴、長井洋平、岩槻政晃、岩上志朗、宮本裕士、吉田直矢、馬場秀夫
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食道癌における予後栄養指数(PNI)と腫瘍局所免疫動態の関連2018

    • Author(s)
      岡留一雄、馬場祥史、八木泰祐、黒田大介、澤山浩、日吉幸晴、岩槻政晃、宮本裕士、吉田直矢、馬場秀夫
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] IDO1 high expression is associated with a poor prognosis in patients with esophageal cancer2018

    • Author(s)
      Yuki Kiyozumi, Yoshifumi Baba, Taisuke Yagi, Yuki Koga, Tomoyuki Uchihara, Daisuke Kuroda, Hiroshi Sawayama, Ryuichi Krashima, Yukiharu Hiyoshi, Takatsugu Ishimoto, Masaaki Iwatsuki, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
    • Organizer
      Association for Cancer Research 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-07-21   Modified: 2020-03-30  

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