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New concept of electroretinography in photoreceptor degenerative diseases

Research Project

Project/Area Number 17K19721
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Surgery related to the biological and sensory functions and related fields
Research InstitutionMie University

Principal Investigator

Kondo Mineo  三重大学, 医学系研究科, 教授 (80303642)

Co-Investigator(Kenkyū-buntansha) 杉本 昌彦  三重大学, 医学部附属病院, 講師 (00422874)
生杉 謙吾  三重大学, 医学系研究科, 准教授 (10335135)
松原 央  三重大学, 医学部附属病院, 講師 (20378409)
Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords網膜電図 / 動物モデル / ウサギ / a波 / ERG / 視細胞変性 / 網膜色素変性 / 視細胞 / 薬理学的実験 / トランスジェニック / 細胞起源 / 網膜変性
Outline of Final Research Achievements

It is widely believed that the origin of the a-wave of electroretinogram (ERG) is mainly the photoreceptors. However, it was unknown this hypothesis is really true in the retina with severe photoreceptor degeneration. In this study, we studied the origin of the a-wave in the retina with severe photoreceptor degeneration using transgenic (Tg) rabbit model of photoreceptor degeneration. Aged Tg rabbit model of 2-3 years were used. The a-waves were recorded before and after intravitreal injection of tetrodotoxin (TTX)and N-methyl-D-aspartic acid (NMDA) in aged Tg rabbits. We found that the small a-wave, which was seen in in aged Tg rabbits, was nearly completely suppressed after intravitreal injection of TTX and NMDA. These results suggested that the small a-waves which are seen in patients with severe photoreceptor degeneration, like retinitis pigmentosa, can originate from retinal third-order neurons.

Academic Significance and Societal Importance of the Research Achievements

今回の我々の成果によって、網膜変性をERG で評価する際の原理に新しい解釈が加わる可能性がある。「進行した網膜色素変性から記録されるERG のa 波には視細胞の成分はほとんど含まれておらず、その多くは3 次ニューロン由来である」、という今回の結果は、視覚科学の分野で長年信じられてきたERG の常識を大きく変える可能性がある。また、今回の我々の成果は、視細胞が変性していく過程で網膜内に起こっている二次的な回路の変化(視細胞変性後の網膜内ニューロンのリモデリング:Jones, Kondo, et al. Jpn J Ophthalmol. 2012)にも新しい知見を加えると考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (54 results)

All 2020 2019 2018 2017

All Journal Article (41 results) (of which Int'l Joint Research: 20 results,  Peer Reviewed: 41 results,  Open Access: 32 results) Presentation (13 results) (of which Int'l Joint Research: 13 results,  Invited: 2 results)

  • [Journal Article] Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.2020

    • Author(s)
      Yang L, Fujinami K, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K; JEGC study group.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-020-62119-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coexistence of GNAT1 and ABCA4 variants associated with Nougaret-type congenital stationary night blindness and childhood-onset cone-rod dystrophy2020

    • Author(s)
      Hayashi T, Hosono K, Kurata K, Katagiri S, Mizobuchi K, Ueno S, Kondo M, Nakano T, Hotta Y
    • Journal Title

      Documenta Ophthalmologica

      Volume: 140 Issue: 2 Pages: 1140-157

    • DOI

      10.1007/s10633-019-09727-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparisons of Effective Fields of Two Ultra-Widefield Ophthalmoscopes, Optos 200Tx and Clarus 5002019

    • Author(s)
      Matsui Y, Ichio A, Sugawara A, Uchiyama E, Suimon H, Matsubara H, Sugimoto M, Ikesugi K, Kondo M
    • Journal Title

      Biomed Res Int

      Volume: 2019 Pages: 7436293-7436293

    • DOI

      10.1155/2019/7436293

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparisons of Effective Fields of Two Ultra-Widefield Ophthalmoscopes, Optos 200Tx and Clarus 5002019

    • Author(s)
      Matsui Y, Ichio A, Sugawara A, Uchiyama E, Suimon H, Matsubara H, Sugimoto M, Ikesugi K, Kondo M
    • Journal Title

      Biomed Res Int

      Volume: 2019 Pages: 7436293-7436293

    • DOI

      10.1007/978-3-030-27378-1_60

    • ISBN
      9783030273774, 9783030273781
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intraocular pressure elevation after subtenon triamcinolone acetonide injection; Multicentre retrospective cohort study in Japan2019

    • Author(s)
      Maeda Y, Ishikawa H, Nishikawa H, Shimizu M, Kinoshita T, Ogihara R, Kitano S, Yamanaka C, Mitamura Y, Sugimoto M, Kondo M, Takamura Y, Ogata N, Ikeda T, Gomi F
    • Journal Title

      PLoS One

      Volume: 14 Issue: 12 Pages: e0226118-e0226118

    • DOI

      10.1371/journal.pone.0226118

    • NAID

      120006812016

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Size of the Foveal Avascular Zone and Carbohydrate Metabolic Disorders during Pregnancy2019

    • Author(s)
      Sugimoto M, Wakamatsu Y, Miyata R, Matsubara H, Kondo M, Kamimoto Y, Ikeda T
    • Journal Title

      Biomed Res Int

      Volume: 2019 Pages: 3261279-3261279

    • DOI

      10.1155/2019/3261279

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ISCEV extended protocol for the S-cone ERG2019

    • Author(s)
      Perlman I, Kondo M, Chelva E, Robson AG, Holder GE
    • Journal Title

      Doc Ophthalmol

      Volume: 140 Issue: 2 Pages: 95-101

    • DOI

      10.1007/s10633-019-09730-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of GUCA1A-associated dominant cone/cone-rod dystrophy: low prevalence among Japanese patients with inherited retinal dystrophies.2019

    • Author(s)
      Mizobuchi K, Hayashi T, Katagiri S, Yoshitake K, Fujinami K, Yang L, Kuniyoshi K, Shinoda K, Machida S, Kondo M, Ueno S, Terasaki H, Matsuura T, Tsunoda K, Iwata T, Nakano T.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-019-52660-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical stages of occult macular dystrophy based on optical coherence tomographic findings2019

    • Author(s)
      Nakamura Natsuko、Tsunoda Kazushige、Mizuno Yoshinobu、Usui Tomoaki、Hatase Tetsuhisa、Ueno Shinji、Kuniyoshi Kazuki、Hayashi Takaaki、Katagiri Satoshi、Kondo Mineo、Kameya Shuhei、Yoshitake Kazutoshi、Fujinami Kaoru、Iwata Takeshi、Miyake Yozo
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 60 Issue: 14 Pages: 4691

    • DOI

      10.1167/iovs.19-27486

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Refractive error and biometrics of anterior segment of eyes of healthy young university students in Japan2019

    • Author(s)
      Kato K, Kondo M, Takeuchi M, Hirano K
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 15337-15337

    • DOI

      10.1038/s41598-019-51920-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk Factors of Neovascular Glaucoma After 25-gauge Vitrectomy for Proliferative Diabetic Retinopathy with Vitreous Hemorrhage: A Retrospective Multicenter Study2019

    • Author(s)
      Takayama K, Someya H, Yokoyama H, Takamura Y, Morioka M, Sameshima S, Ueda T, Kitano S, Tashiro M, Sugimoto M, Kondo M, Sakamoto T, Takeuchi M
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 14858-14858

    • DOI

      10.1038/s41598-019-51411-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide association study and whole-genome sequencing identify a deletion in LRIT3 associated with canine congenital stationary night blindness.2019

    • Author(s)
      Das RG, Becker D, Jagannathan V, Goldstein O, Santana E, Carlin K, Sudharsan R, Leeb T, Nishizawa Y, Kondo M, Aguirre GD, Miyadera K
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 14166-14166

    • DOI

      10.1038/s41598-019-50573-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Management of Postoperative Inflammation and Dry Eye After Cataract Surgery.2019

    • Author(s)
      Kato K, Miyake K, Hirano K, Kondo M
    • Journal Title

      Cornea

      Volume: 38 Suppl Issue: 1 Pages: S25-S33

    • DOI

      10.1097/ico.0000000000002125

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of vascular infarction-related molecules after anti-vascular endothelium growth factor treatment for diabetic macular edema2019

    • Author(s)
      Sugimoto M, Wakamatsu Y, Miyata R, Nunome T, Tenma Y, Matsubara H, Kondo M, Wada H, Nakatani K
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 12373-12373

    • DOI

      10.1038/s41598-019-48869-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current practice in the management of branch retinal vein occlusion in Japan: Survey results of retina specialists in Japan.2019

    • Author(s)
      Ogura Y, Kondo M, Kadonosono K, Shimura M, Kamei M, Tsujikawa A
    • Journal Title

      Jpn J Ophthalmol

      Volume: 63 Issue: 5 Pages: 365-373

    • DOI

      10.1007/s10384-019-00685-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in VEGF-related factors are associated with presence of inflammatory factors in carbohydrate metabolism disorders during pregnancy2019

    • Author(s)
      Sugimoto M, Kondo M, Kamimoto Y, Ikeda T, Cutler A, Mariya A, Anand-Apte B
    • Journal Title

      PLoS One

      Volume: 14 Issue: 8 Pages: e0220650-e0220650

    • DOI

      10.1371/journal.pone.0220650

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrically Evoked Potentials Are Reduced Compared to Axon Numbers in Rhodopsin P347L Transgenic Rabbits With Severe Photoreceptor Degeneration.2019

    • Author(s)
      Kominami T, Ueno S, Nishida K, Inooka D, Kominami A, Kondo M, Terasaki H.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 60 Issue: 7 Pages: 2543-2550

    • DOI

      10.1167/iovs.19-26972

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tilted Disc Syndrome Associated with Serous Retinal Detachment: Long-term Prognosis. A Retrospective Multicenter Survey.2019

    • Author(s)
      Kubota F, Suetsugu T, Kato A, Gomi F, Takagi S, Kinoshita T, Ishikawa H, Mitamura Y, Kondo M, Iwahashi C, Kuwayama S, Kurimoto Y, Ogura Y, Yasukawa T; Japanese Clinical Retina Study (J-CREST) Group.
    • Journal Title

      Am J Ophthalmol

      Volume: 207 Pages: 313-318

    • DOI

      10.1016/j.ajo.2019.05.027

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Course of loss of photoreceptor function and progressive Mueller cell gliosis in rhodopsin P347L transgenic rabbits.2019

    • Author(s)
      Ueno S, Kominami T, Okado S, Inooka D, Kondo M, Terasaki H.
    • Journal Title

      Experimental Eye Research

      Volume: 184 Pages: 192-200

    • DOI

      10.1016/j.exer.2019.04.026

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake disease); EAOMD Report No.12019

    • Author(s)
      Fujinami Kaoru、Yang Lizhu、Joo Kwangsic、Tsunoda Kazushige、Kameya Shuhei、Hanazono Gen、Fujinami-Yokokawa Yu、Arno Gavin、Kondo Mineo、Nakamura Natsuko、Kurihara Toshihide、Tsubota Kazuo、Zou Xuan、Li Hui、Park Kyu Hyung、Iwata Takeshi、Miyake Yozo、Woo Se Joon、Sui Ruifang
    • Journal Title

      Ophthalmology

      Volume: - Issue: 10 Pages: 1432-1444

    • DOI

      10.1016/j.ophtha.2019.04.032

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ISCEV extended protocol for the stimulus-response series for light-adapted full-field ERG2019

    • Author(s)
      McCulloch DL, Kondo M, Hamilton R, Lachapelle P, Messias AMV, Robson AG, Ueno S
    • Journal Title

      Doc Ophthalmol

      Volume: 印刷中 Issue: 3 Pages: 205-215

    • DOI

      10.1007/s10633-019-09685-8

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Central serous chorioretinopathy with and without steroids: A multicenter survey2019

    • Author(s)
      Araki T, Ishikawa H, Iwahashi C, Niki M, Mitamura Y, Sugimoto M, Kondo M, Kinoshita T, Nishi T, Ueda T, Kato A, Yasukawa T, Takamura Y, Gomi F
    • Journal Title

      PLoS One

      Volume: 14 Issue: 2 Pages: e0213110-e0213110

    • DOI

      10.1371/journal.pone.0213110

    • NAID

      120006812008

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel mutations in the RS1 gene in Japanese patients with X-linked congenital retinoschisis2019

    • Author(s)
      Kondo Hiroyuki、Oku Kazuma、Katagiri Satoshi、Hayashi Takaaki、Nakano Tadashi、et al.
    • Journal Title

      Human Genome Variation

      Volume: 6 Issue: 1 Pages: 3-3

    • DOI

      10.1038/s41439-018-0034-6

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CLINICAL COURSE OF PARANEOPLASTIC RETINOPATHY WITH ANTI-TRPM1 AUTOANTIBODY IN JAPANESE COHORT2019

    • Author(s)
      Ueno S, Inooka D, Nakanishi A, Okado S, Yasuda S, Kominami T, Sayo A, Morimoto T, Kondo M, Katagiri S, Hayashi T, Terasaki H
    • Journal Title

      Retina

      Volume: 印刷中 Issue: 12 Pages: 2410-2418

    • DOI

      10.1097/iae.0000000000002329

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New clinical ultrahigh-resolution SD-OCT using A-scan matching algorithm2019

    • Author(s)
      Matsui Y, Kondo M, Uchiyama E, Mityata R, Matsubara H
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 257 Issue: 2 Pages: 255-263

    • DOI

      10.1007/s00417-018-4183-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Scleral buckling versus vitrectomy for young japanese patients with rhegmatogenous retinal detachment in the era of microincision surgery: real-world evidence from a multicentre study in Japan2019

    • Author(s)
      Shu I, Ishikawa H, Nishikawa H, Morikawa S, Okamoto F, Sakamoto T, Sugimoto M, Kondo M, Iwasaki M, Kinoshita T, Toibana T, Mitamura Y, Takamura Y, Motohashi R, Shimura M, Sakurai Y, Takeuchi M, Gomi F
    • Journal Title

      Acta Ophthalmol

      Volume: 印刷中 Issue: 5

    • DOI

      10.1111/aos.14050

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association between Retinal Nerve Fiber Layer Thickness and Eye Fatigue2019

    • Author(s)
      Ayaki M, Kuze M, Kondo M, Tsubota K, Negishi K
    • Journal Title

      Biomed Res Int

      Volume: 2019 Pages: 3014567-3014567

    • DOI

      10.1155/2019/3014567

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genotype determination of the OPN1LW/OPN1MW genes: novel disease-causing mechanisms in Japanese patients with blue cone monochromacy.2018

    • Author(s)
      Katagiri S, Iwasa M, Hayashi T, Hosono K, Yamashita T, Kuniyoshi K, Ueno S, Kondo M, Ueyama H, Ogita H, Shichida Y, Inagaki H, Kurahashi H, Kondo H, Ohji M, Hotta Y, Nakano T.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 11507-11507

    • DOI

      10.1038/s41598-018-29891-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical preferences and trends of anti-vascular endothelial growth factor treatments for diabetic macular edema in Japan2018

    • Author(s)
      Sugimoto Masahiko、Tsukitome Hideyuki、Okamoto Fumiki、Oshika Tetsuro、Ueda Tetsuo、Niki Masanori、Mitamura Yoshinori、Ishikawa Hiroto、Gomi Fumi、Kitano Shigehiko、Noma Hidetaka、Shimura Masahiko、Sonoda Shozo、Sawada Osamu、Ohji Masahito、Harimoto Kozo、Takeuchi Masaru、Takamura Yoshihiro、Kondo Mineo、Sakamoto Taiji
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 10 Issue: 2 Pages: 475-483

    • DOI

      10.1111/jdi.12929

    • NAID

      120006980552

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Focal Choroidal Excavation Development Associated with Multiple Evanescent White Dot Syndrome2018

    • Author(s)
      Matsubara H, Uchiyama E, Suzuki K, Matsuda Y, Kondo M
    • Journal Title

      Case Rep Ophthalmol

      Volume: 9 Issue: 2 Pages: 388-394

    • DOI

      10.1159/000492747

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Supernormal Flicker ERGs in Eyes With Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent2018

    • Author(s)
      Miyata Ryohei、Kondo Mineo、Kato Kumiko、Sugimoto Masahiko、Matsubara Hisashi、Ikesugi Kengo、Ueno Shinji、Yasuda Shunsuke、Terasaki Hiroko
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 59 Issue: 15 Pages: 5854-5854

    • DOI

      10.1167/iovs.18-25087

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inherited Retinal Degeneration: Genetics, Disease Characterization, and Outcome Measures2017

    • Author(s)
      Khan NW, Falsini B, Kondo M, Robson AG
    • Journal Title

      J Ophthalmol

      Volume: 2017 Pages: 2109014-2109014

    • DOI

      10.1155/2017/2109014

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Temporal Properties of Flicker ERGs in Rabbit Model of Retinitis Pigmentosa.2017

    • Author(s)
      Okado S, Ueno S, Kominami T, Nakanishi A, Inooka D, Sayo A, Kondo M, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 1;58 Issue: 12 Pages: 5518-5525

    • DOI

      10.1167/iovs.17-22332

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors Affecting Mydriasis-Free Flicker ERGs Recorded With Real-Time Correction for Retinal Illuminance: Study of 150 Young Healthy Subjects.2017

    • Author(s)
      Kato K, Kondo M, Nagashima R, Sugimoto M, Matsubara H, McCulloch DL, Ikesugi K
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 58 Issue: 12 Pages: 5280-5286

    • DOI

      10.1167/iovs.17-22587

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unilateral cancer-associated retinopathy: diagnosis, serology and treatment2017

    • Author(s)
      Roels D, Ueno S, Talianu CD, Draganova D, Kondo M, Leroy BP
    • Journal Title

      Doc Ophthalmol

      Volume: 135 Issue: 3 Pages: 233-240

    • DOI

      10.1007/s10633-017-9605-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New photic stimulating system with white light-emitting diodes to elicit electroretinograms from zebrafish larvae2017

    • Author(s)
      Hisashi Matsubara, Yoshitsugu Matsui, Ryohei Miyata, Yuhei Nishimura, Tetsuro Yamamoto, Toshio Tanaka, Mineo Kondo
    • Journal Title

      Documenta Ophthalmologica

      Volume: 135 Issue: 2 Pages: 147-154

    • DOI

      10.1007/s10633-017-9602-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conjunctival Goblet Cell Density Following Cataract Surgery With Diclofenac Versus Diclofenac and Rebamipide: A Randomized Trial2017

    • Author(s)
      Kato K, Miyake K, Kondo N, Asano S, Takeda J, Takahashi A, Takashima Y, Kondo M
    • Journal Title

      Am J Ophthalmol

      Volume: 181 Pages: 26-36

    • DOI

      10.1016/j.ajo.2017.06.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of intravitreal ranibizumab on the ocular circulation of the untreated fellow eye2017

    • Author(s)
      Sugimoto M, Nunome T, Sakamoto R, Kobayashi M, Kondo M
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 255 Issue: 8 Pages: 1543-1550

    • DOI

      10.1007/s00417-017-3692-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Annual incidences of visual impairment during 10-year period in Mie prefecture, Japan2017

    • Author(s)
      Ikesugi K, Ichio T, Tsukitome H, Kondo M
    • Journal Title

      Jpn J Ophthalmol

      Volume: 61 Issue: 4 Pages: 293-298

    • DOI

      10.1007/s10384-017-0517-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxidative Stress in Retinal Diseases2017

    • Author(s)
      Nishimura Y, Hara H, Kondo M, Hong S, Matsugi T
    • Journal Title

      Oxid Med Cell Longev

      Volume: 2017 Issue: 1 Pages: 4076518-4076518

    • DOI

      10.1155/2017/4076518

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two year result of intravitreal bevacizumab for diabetic macular edema using treat and extend protocol2017

    • Author(s)
      Sugimoto M, Ichio A, Nunome T, Kondo M
    • Journal Title

      Medicine (Baltimore)

      Volume: 96 Issue: 16 Pages: e6406-e6406

    • DOI

      10.1097/md.0000000000006406

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Clinical applications of the mfERG2019

    • Author(s)
      Kondo M
    • Organizer
      57th ISCEV SYMPOSIUM
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A clinical diagnostic approach to retinal disease.2019

    • Author(s)
      Kondo M
    • Organizer
      57th ISCEV SYMPOSIUM
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ISCEV Instruction Course: Clinical Usefulness of Electrophysiology.2019

    • Author(s)
      Kondo M
    • Organizer
      APAO
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Supernormal Flicker ERGs in Eyes with Central Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent.2019

    • Author(s)
      Kondo M
    • Organizer
      42nd ANNUAL MEETING MACULA SOCIETY
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2.Screening for diabetic retinopathy using mydriasis-free full-field flicker ERG device2019

    • Author(s)
      Kondo M
    • Organizer
      Macula Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical application of multifocal ERG2018

    • Author(s)
      Kondo M
    • Organizer
      The 50th Annual Symposium of the International Society for Clinical Electrophysiology of Vision (ISCEV)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3.Supernormal flicker ERGs in eyes with central retinal vein occlusion: Clinical characteristics, prognosis, and effects of anti-VEGF agent2018

    • Author(s)
      Kondo M
    • Organizer
      The 11th Joint Meeting of Japan-Korea-China Ophthalmologists
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical application of mfERG2017

    • Author(s)
      Kondo M
    • Organizer
      The 55th Annual Symposium of the International Society for Clinical Electrophysiology of Vision
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diagnostic approach to retinal disease2017

    • Author(s)
      Kondo M
    • Organizer
      Annual Symposium of the International Society for Clinical Electrophysiology of Vision
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Screening for diabetic retinopathy using new mydriasis-free, full-field flicker ERG recording device2017

    • Author(s)
      Kondo M, Fukuo M, Ikesugi K, Sugimoto M, Kato K, Kitano S
    • Organizer
      ISCEV at ARVO
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Factors Affecting Mydriasis-Free Flicker ERGs Recorded With Real-Time Correction for Retinal Illuminance: Study for 150 Young Normal Subjects2017

    • Author(s)
      Kondo M, Kato K, Nagashima R, Sugawara A, Matsubara H, Sugimoto M, McCulloch DL, Ikesugi K
    • Organizer
      The 55th Annual Symposium of the International Society for Clinical Electrophysiology of Vision
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Short-wavelength sensitive cone ERG2017

    • Author(s)
      Kondo M
    • Organizer
      The 55th Annual Symposium of the International Society for Clinical Electrophysiology of Vision
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Screening for diabetic retinopathy using new mydriasis-free, full-field flicker ERG recording device2017

    • Author(s)
      Kondo M, Fukuo M, Kato K, Sugimoto M, Kitano S
    • Organizer
      The 10th Joint Meeting of Korea-China-Japan Ophthalmologists in conjunction with the 118th Annual Meeting of the Korean Ophthalmological Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-07-21   Modified: 2023-03-23  

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