| Project/Area Number |
17K19741
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Oral Science and related fields
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 直毅 東北大学, 加齢医学研究所, 非常勤講師 (50625043)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | がん / 癌 |
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| Outline of Final Research Achievements |
Although immune checkpoint inhibitors have been effective against intractable tumors, we hope more effective treatments. Therefore, we performed a study to detect tumor-specific T cell receptors. When mouse peripheral tissues around tumors and lymphoid tissues were collected using a tumor-bearing mouse model, T cell accumulation was observed around the tumors. In addition, it was possible to detect T cell receptors that are considered to be tumor-specific in lymphoid tissues around the tumor. Furthermore, we were able to establish a comprehensive analysis method for T cell receptors.
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| Academic Significance and Societal Importance of the Research Achievements |
研究成果の学術的意義や社会的意義：本研究は、難治がんに対する免疫療法の効果向上および新規治療法開発への基盤を確立する研究である。マウスモデルを用いて、がんに対するT細胞受容体を、我々が構築した方法により検出することができた。本研究により、遺伝子特異的非バイアス増幅法を用いた、がんに対するT細胞受容体の検出方法を確立することができたことは、今後の臨床応用への大きな前進であって、学術的にも社会的にも意義のある成果である。
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