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Exploring nano-surface topography of dental implants to regulate osteoimmunology

Research Project

Project/Area Number 17K19742
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Oral Science and related fields
Research InstitutionTohoku University

Principal Investigator

Yamada Masahiro  東北大学, 歯学研究科, 准教授 (90549982)

Co-Investigator(Kenkyū-buntansha) 江草 宏  東北大学, 歯学研究科, 教授 (30379078)
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsメカノトランスダクション / ナノテクノロジー / 表面改質 / 骨免疫 / インプラント / ナノ形態 / インプラント周囲炎
Outline of Final Research Achievements

The cell culture experiment using mouse macrophage (MΦ) cell line showed that the polarization of MΦ is controlled on the titanium nano-roughened surface in contrast with the machined titanium surface. In addition, histological evaluations of peri-implant bone resorption around titanium implants were performed in a peri-implantitis model on rat maxilla. Severe gingival inflammation and bone resorption were observed in the peri-implant tissue around the machined titanium implants. In contrast, despite inflammatory reactions in peri-implant gingival tissue, gingival degradation and bone resorption were hardly observed in the peri-implant tissue around titanium implants with the nano-roughened surface. Those results suggested that nano-roughened titanium surfaces may inhibit the gingival degradation and bone resorption due to bacterial infectious inflammation by promoting the polarization of MΦ.

Academic Significance and Societal Importance of the Research Achievements

骨結合促進を目的としたチタン表面のナノ改質技術は散見されるが,インプラント頸部に慢性炎症の結果生じる骨吸収という問題に対して,骨免疫機序に着目し,細胞移植や生理活性物質の投与ではなく,ナノ技術を駆使してチタンインプラント表面の改質のみで制御することを証明した学術的意義は大きい.本研究の成果は,未だ解決策が無いインプラント周囲骨吸収に対して具体的な予防技術を提供するとともに,整形外科インプラントや骨補填材を含む生体材料に関連した慢性炎症の問題解決の一助にもなる.さらに,広い分野の臨床・基礎研究領域で活かされる可能性を大いに含んでおり,萌芽的な技術概念を創出したと考えられる.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Current bone substitutes for implant dentistry2018

    • Author(s)
      Yamada M, Egusa H
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 62 Issue: 2 Pages: 152-161

    • DOI

      10.1016/j.jpor.2017.08.010

    • NAID

      130006733089

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress2018

    • Author(s)
      Watanabe Jun、Yamada Masahiro、Niibe Kunimichi、Zhang Maolin、Kondo Takeru、Ishibashi Minoru、Egusa Hiroshi
    • Journal Title

      Biomaterials

      Volume: 185 Pages: 25-38

    • DOI

      10.1016/j.biomaterials.2018.08.055

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of titanium nano-surfaces on prevention of peri-implantitis.2019

    • Author(s)
      Kartikasari N, Yamada M, Egusa H.
    • Organizer
      第8回補綴若手研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] バイオミメティックインプラントによる軟組織付着獲得への挑戦2018

    • Author(s)
      山田将博
    • Organizer
      第48回日本口腔インプラント学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 歯根セメント質表面の微小硬度と表面形態の評価2018

    • Author(s)
      山田将博,吉岡勇人,新野秀憲,江草 宏
    • Organizer
      平成29年度生体医歯工学共同研究拠点成果報告会
    • Related Report
      2017 Research-status Report
  • [Presentation] Redox biology-based strategy in bone regeneration for efficient transplantation of osteoblastic cells.2017

    • Author(s)
      Watanabe J, Yamada M, Egusa H.
    • Organizer
      International meeting the 7th Temu Ilmiah Nasional and 4th Scientific Meeting in Dentistry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] インプラント表面性状の解釈とその骨結合能を推測する方法2017

    • Author(s)
      山田将博
    • Organizer
      平成29年度(公社)日本補綴歯科学会 東北・北海道支部学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 東北大学クラウンブリッジ模型実習におけるCAD/CAM冠教育とその効果2017

    • Author(s)
      勝田悠介,山田将博,奥山弥生,石橋 実,江草 宏
    • Organizer
      平成29年度(公社)日本補綴歯科学会 東北・北海道支部学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] N-acetyl-L-cysteine Reinforces Apoptosis Resistance of MSCs to Promote Bone Regeneration.2017

    • Author(s)
      Watanabe J, Yamada M, Egusa H.
    • Organizer
      Hatton competition of Japanese Association for Dental Research 65th Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] The Fabric of the Modern Implantology 近代インプラント治療のテクニックとサイエンス2017

    • Author(s)
      船登彰芳,山田将博,吉松繁人
    • Total Pages
      240
    • Publisher
      医歯薬出版株式会社
    • ISBN
      9784263461358
    • Related Report
      2017 Research-status Report
  • [Remarks] ​東北大学 大学院歯学研究科 分子・再生歯科補綴学分野ホームページ

    • URL

      http://crbr.dent.tohoku.ac.jp/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-21   Modified: 2020-03-30  

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