| Project/Area Number |
17K19746
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Oral Science and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ogasawara Toru 東京大学, 保健・健康推進本部, 講師 (20359623)
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| Co-Investigator(Kenkyū-buntansha) |
筑田 博隆 群馬大学, 大学院医学系研究科, 教授 (30345219)
茂呂 徹 東京大学, 医学部附属病院, 特任教授 (20302698)
阿部 雅修 東京大学, 医学部附属病院, 講師 (10392333)
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| Project Period (FY) |
2017-06-30 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | シグナル伝達 / 再生医学 / 発生・分化 / 細胞周期 / エクソソーム |
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| Outline of Final Research Achievements |
In the present study, we investigated the existence of an exosome-mediated signaling mechanism between osteoclasts and osteoblasts and its involvement in cell cycle regulation and cell differentiation. However, we could not clearly demonstrate the existence of an exosome-mediated signaling mechanism between osteoblasts and osteoclasts. Therefore, we searched for candidate microRNAs in mouse osteoblast-derived exosomes using small RNA sequencing. We identified mmu-miR-26a-5p as a microRNA that may be involved in the inhibition of osteogenesis, and mmu-miR-214-3p as a microRNA that may be involved in the promotion of osteogenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって、骨形成抑制に関わる可能性を持つマイクロRNAとしては、mmu-miR-26a-5pなどの2分子を、骨形成促進に関わる可能性を持つマイクロRNAとしては、mmu-miR-214-3pなどの3分子を同定することが出来た。本研究の成果は、将来的には新たな骨再生医療法開発につながる可能性がある。
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