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Identification of novel targets and concepts for cancer therapy

Research Project

Project/Area Number 17K19748
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Oral Science and related fields
Research InstitutionNiigata University

Principal Investigator

Terunuma Miho  新潟大学, 医歯学系, 教授 (50615739)

Co-Investigator(Kenkyū-buntansha) 山崎 学  新潟大学, 医歯学系, 助教 (10547516)
三上 剛和  新潟大学, 医歯学系, 准教授 (80434075)
Research Collaborator Amaya Yoshihiro  
Harada Fumiko  
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
KeywordsAMPK / 口腔癌 / 扁平上皮癌 / GABA / シグナル伝達 / 口腔がん / キナーゼ / 神経伝達物質 / 口腔扁平上皮癌 / GABAB受容体 / AMPキナーゼ / 蛋白質 / 癌
Outline of Final Research Achievements

We examined the anticancer effect of cellular energy sensor AMPK and inhibitory neurotransmitter receptor GABAB receptor and their functional crosstalk in oral cancer cells. We found that the structure of GABAB receptors are different from that of neuronal GABAB receptors and their activation did not induce anti-cancer effect. On the other hand, AMPK activation strongly suppressed the cancer proliferation. Therefore, in oral cancer, AMPK downstream signaling maybe a good target for novel drug development.

Academic Significance and Societal Importance of the Research Achievements

本研究により、他の組織のがんで報告されていたGABAB受容体の活性化によるがん抑制効果が口腔がんでは発揮されないことが明らかとなった。一方、AMPKやその下流分子の活性化が効果的な癌抑制効果を生み出すことも明らかとなり、今後これらを標的とした研究が、新規抗がん剤の開発などに繋がる可能性がある。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Diversity of structure and function of GABA<sub>B</sub> receptors: a complexity of GABA<sub>B</sub>-mediated signaling2018

    • Author(s)
      TERUNUMA Miho
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 94 Issue: 10 Pages: 390-411

    • DOI

      10.2183/pjab.94.026

    • NAID

      130007529109

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2018-12-11
    • Related Report
      2018 Annual Research Report
  • [Journal Article] A Role for Prefrontal Cortical NMDA Receptors in Murine Alcohol-Heightened Aggression.2018

    • Author(s)
      Newman EL, Terunuma M, Wang TL, Hewage N, Bicakci MB, Moss SJ, DeBold JF, Miczek KA.
    • Journal Title

      Neuropsychopharmacology

      Volume: 43(6) Issue: 6 Pages: 1224-1234

    • DOI

      10.1038/npp.2017.253

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Metformin, an anti-diabetic agent inhibits oral cancer cell proliferation and migration.2019

    • Author(s)
      Genki Ito, Ritsuo Takagi, Miho Terunuma
    • Organizer
      International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Neuroprotective role of GABAB receptors against hypoxia.2018

    • Author(s)
      Miho Terunuma
    • Organizer
      2018 GABAB Receptor Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuroprotective role of GABAB receptors against hypoxia2018

    • Author(s)
      Miho Terunuma and Stephen J Moss
    • Organizer
      GABAB receptor conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脳のお掃除屋さん:アストロサイトの様々な機能2018

    • Author(s)
      照沼 美穂
    • Organizer
      N-Hybrid Conference 2018
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification of novel molecule which involves in glutamine synthetase-mediated ammonium metabolism2017

    • Author(s)
      Miho Terunuma
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Blockade of GABAB receptor endocytosis enhances neuroprotection2017

    • Author(s)
      Miho Terunuma
    • Organizer
      ISN-ESN Biennial Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抑制性神経伝達物質の新たな機能2017

    • Author(s)
      照沼 美穂
    • Organizer
      歯科基礎医学会
    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2020-03-30  

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