• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Crosstalk between the neural circuit for controlling mastication and the autonomic nervous system

Research Project

Project/Area Number 17K19775
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Oral Science and related fields
Research InstitutionShowa University

Principal Investigator

INOUE TOMIO  昭和大学, 歯学部, 教授 (70184760)

Co-Investigator(Kenkyū-buntansha) 中山 希世美  昭和大学, 歯学部, 講師 (00433798)
望月 文子  昭和大学, 歯学部, 講師 (10453648)
鬼丸 洋  昭和大学, 医学部, 客員教授 (30177258)
中村 史朗  昭和大学, 歯学部, 准教授 (60384187)
Research Collaborator IKEDA Keiko  
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
KeywordsPhox2b / 顎運動 / 三叉神経上核 / グルタミン酸作動性 / GABA作動性 / グリシン作動性 / 発火パターン / パッチクランプ / グルタミン酸性ニューロン / 三叉神経運動ニューロン / GABA性ニューロン / グリシン性ニューロン / オレキシン / 結合腕傍核 / 光遺伝学
Outline of Final Research Achievements

The supratrigeminal nucleus and the parabrachial nucleus are located dorsal to the trigeminal motor nucleus (RdV). The former is related to controlling jaw movements and the latter receives autonomic inputs. Furthermore, PHOX2B is essential for autonomic nervous system development and the neurons expressing Phox2b (Phox2b+ neurons) are abundantly found in the RdV. In this study, we examined the properties of Phox2b+ neurons located in the RdV. Phox2b+ neurons were glutamatergic, whereas Phox2b-negative (Phox2b-) neurons are GABAergic and glycinergic. Phox2b+ neurons showed low-frequency firing, while Phox2b- neurons exhibited high-frequency firing. About half of the Phox2b+ and Phox2b- neurons send their axons to the trigeminal motor nucleus. These results suggest that Phox2b+ neurons have clearly different properties from Phox2b- neurons and might play important roles in feeding-related functions under the crosstalk control between motor and autonomic systems.

Academic Significance and Societal Importance of the Research Achievements

自律機能と運動機能は、それぞれ生体の恒常性のための重要な機能の一つであり、本来、密接に関わって働いていると考えられる。自律神経系の機能はこれまで詳細に研究されてきたが、運動機能の制御系とのインタラクションの観点でなされたものは極めて少ない。本研究は、咀嚼運動の遂行に関わる三叉神経上核から自律機能に関わる結合腕傍核にわたって存在するPhox2b陽性ニューロンに着目して、自律神経系と咀嚼の運動機能のクロストークの解明を試みるものである。本研究結果は、自律神経系と運動機能の相互作用という新たな学問領域を切り開く可能性を有し、その端緒としての意義は大きいと考えられる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (41 results)

All 2019 2018 2017 Other

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (25 results) (of which Int'l Joint Research: 11 results,  Invited: 2 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Nanomechanical characterization of time-dependent deformation/recovery on human dentin caused by radiation-induced glycation2019

    • Author(s)
      Tobe T, Shibata Y, Mochizuki A, Shimomura N, Zhou J, Wurihan, Tanaka R, Ikeda S, Zhang Z, Li Q, Inoue T, Miyazaki T
    • Journal Title

      J Mech Behav Biomed Mater

      Volume: 90 Pages: 248-255

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Involvement of orexin in lipid accumulation in the liver2018

    • Author(s)
      Mochizuki A, Nakayama K, Nakamura S, Dantsuji M, Kamijo R, Shioda S, Sakurai T, Ozeki M, Inoue T
    • Journal Title

      J Oral Biosci

      Volume: 60(3) Pages: 76-82

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental Study on Involvement of the Central Nervous System in Inferior Alveolar Nerve Damage-Associated Hyperalgesia of the Mental Region2018

    • Author(s)
      Kiyomoto Masaaki、Shirota Tatsuo、Moriya Takashi、Sato Hitoshi、Nakamura Shiro、Inoue Tomio
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 76 Issue: 10 Pages: 2089.e1-2089.e8

    • DOI

      10.1016/j.joms.2018.06.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Generation of orthotopically functional salivary gland from embryonic stem cells2018

    • Author(s)
      Tanaka Junichi、Ogawa Miho、Hojo Hironori、Kawashima Yusuke、Mabuchi Yo、Hata Kenji、Nakamura Shiro、Yasuhara Rika、Takamatsu Koki、Irie Tarou、Fukada Toshiyuki、Sakai Takayoshi、Inoue Tomio、Nishimura Riko、Ohara Osamu、Saito Ichiro、Ohba Shinsuke、Tsuji Takashi、Mishima Kenji
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4216-4216

    • DOI

      10.1038/s41467-018-06469-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 咀嚼制御の神経メカニズム2018

    • Author(s)
      井上富雄
    • Journal Title

      日本咀嚼学会誌

      Volume: 28(2) Pages: 64-71

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Confocal calcium imaging analysis of respiratory-related burst activity in the parafacial region.2018

    • Author(s)
      Onimaru H, Nakamura S, Ikeda K, Kawakami K, Inoue T.
    • Journal Title

      Brain Res Bull.

      Volume: 139 Pages: 16-20

    • DOI

      10.1016/j.brainresbull.2018.01.013

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Premotoneuronal inputs to early developing trigeminal motoneurons2017

    • Author(s)
      Matsuda K, Nakamura S, Nonaka M, Mochizuki A, Nakayama K, Iijima T, Yokoyama A, Funahashi M, Inoue T
    • Journal Title

      Journal of Oral Biosciences

      Volume: 印刷中 Issue: 2 Pages: 96-103

    • DOI

      10.1016/j.job.2017.01.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distinctive features of Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus2017

    • Author(s)
      Nagoya K, Nakamura S, Ikeda K, Onimaru H, Yoshida A, Nakayama K, Mochizuki A, Kiyomoto M, Satoh F, Kawakami H, Takahashi K, Inoue T.
    • Journal Title

      Neuroscience

      Volume: 358 Pages: 211-226

    • DOI

      10.1016/j.neuroscience.2017.06.035

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Central Neural Mechanisms Involved in the Control of Jaw Movement during Postnatal Development2017

    • Author(s)
      NAKAMURA Shiro、NAGATA Shoko、NONAKA Mutsumi、NISHIMURA Akiko、NAGOYA Kouta、DANTSUJI Masanori、NAKAYAMA Kiyomi、MOCHIZUKI Ayako、IIJIMA Takehiko、OZEKI Masahiko、YAMAMOTO Matsuo、INOUE Tomio
    • Journal Title

      The Showa University Journal of Medical Sciences

      Volume: 29 Issue: 3 Pages: 221-229

    • DOI

      10.15369/sujms.29.221

    • NAID

      130006219349

    • ISSN
      0915-6380, 2185-0968
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of optogenetic inhibition of 5-HT neurons in the dorsal raphe nucleus on respiratory control.2019

    • Author(s)
      Kanamaru M, Tsukada M, Yoshikawa A, Onimaru H, Mochizuki A,Sunagawa M, Inoue T,Izumizaki M.
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phox2b-expressing neurons in the rat reticular formation dorsal to the trigeminal motor nucleus.2019

    • Author(s)
      Nakamura S, Nagoya K, Ikeda K, Onimaru H, Kawakami K, Nakayama K, Mochizuki A, Dantsuji M, Inoue T.
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Properties of Phox2b-expressing premotor neurons targeting jaw-muscle motoneurons.2019

    • Author(s)
      Inoue T.
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress in conjunction with the 96th Annual Meeting of the Physiological Society of Japan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 嚥下改善薬の投与による嚥下への影響2018

    • Author(s)
      守谷崇, 中山希世美, 望月文子,中村史朗,代田達夫, 井上富雄
    • Organizer
      第65回昭和大学学士会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Activation of 5-HT2A receptor enhances function of GluN2A-containing NMDA receptor via Src kinase in dendrites of rat jaw-closing motoneurons.2018

    • Author(s)
      Dantsuji M, Nakamura S, Mochizuki A, Nakayama K, Kiyomoto M, S. K. Park, Y. J. Bae, Ozeki M, Inoue T.
    • Organizer
      Society for Neuroscience 48th annual meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of pharmacological agents administered for swallowing disorders on swallowing motor activity in nerves innervating infrahyoid and laryngeal muscles.2018

    • Author(s)
      Moriya T, Nakayama K, Nakamura S, Mochizuki A, Shirota T, Inoue T
    • Organizer
      Society for Neuroscience 48th annual meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 閉口筋および開口筋運動ニューロンへの興奮性シナプス伝達の生後発達様式の比較2018

    • Author(s)
      中村史朗,中山希世美,望月文子,壇辻昌典,井上富雄
    • Organizer
      日本顎口腔機能学会第 61 回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウスの脂質代謝におけるオレキシンの影響2018

    • Author(s)
      望月文子,中村史朗,中山希世美,壇辻昌典,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 発達期における閉口筋および開口筋運動ニューロンのグルタミン酸入力比較2018

    • Author(s)
      中村史朗,中山希世美,望月文子,壇辻昌典,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウスの睡眠覚醒ステージにおける咬筋活動に対するSSRIの影響2018

    • Author(s)
      池田美菜子,望月文子,中村史朗,中山希世美,馬場一美,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 咬筋運動ニューロン樹状突起のグルタミン酸応答に対するセロトニンの効果2018

    • Author(s)
      壇辻昌典,中村史朗,望月文子,中山希世美,尾関雅彦,井上富雄
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 5-HT2A receptor mediates enhancement of NMDA receptor function via Src pathway in dendrites of jaw-closing motoneurons in rats2018

    • Author(s)
      Dantsuji M, Nakamura S, Mochizuki A, Nakayama K, Kiyomoto M, S. K. Park, Y. J. Bae, Ozeki M, Inoue T
    • Organizer
      11th Forum of Neuroscience Berlin
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスの睡眠覚醒ステージにおける咬筋活動に対するSSRIの影響2018

    • Author(s)
      池田美菜子,望月文子,中村史朗,中山希世美,馬場一美,井上富雄
    • Organizer
      日本顎口腔機能学会第60回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 転写因子Phox2bを発現する三叉神経運動核背側網様体ニューロンの生理学的および形態学的解析2017

    • Author(s)
      那小屋公太,中村史朗,中山希世美,望月文子,吉田 篤,井上 誠,井上富雄
    • Organizer
      日本顎口腔機能学会第58回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット三叉神経運動核背側網様体に存在するPhox2b陽性ニューロンの生理学的・形態学的性質2017

    • Author(s)
      那小屋公太,中村史朗,中山希世美,望月文子,佐藤文彦,吉田 篤,井上 誠,井上富雄
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Distinctive properties of Phox2b neurons located in the rat reticular formation dorsal to the trigeminal motor nucleus2017

    • Author(s)
      Nagoya K, Nakamura S, Ikeda K, Onimaru H, Nakayama K, Mochizuki A, Sato F, Yoshida A, Kawakami K, Inoue M, Inoue T.
    • Organizer
      Society for Neuroscience 47th annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Glutamatergic synaptic currents of rat jaw-closing motoneurons during transition period from sucking to chewing2017

    • Author(s)
      Nakamura S, Nakayama K, Mochizuki A, Inoue T.
    • Organizer
      Society for Neuroscience 47th annual meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of citalopram administration on the occurrence of vigilance states in the mouse model of depression.2017

    • Author(s)
      Ayako Mochizuki, Minako Ikeda, Shiro Nakamura, Kiyomi Nakayama, Tomio Inoue.
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Postnatal changes of glutamatergic inputs to rat jaw-closing and jaw-opening motoneurons2017

    • Author(s)
      Teshima R, Shimono S, Nakamura S, Nakayama K, Mochizuki A, Ikeda M, Inoue T.
    • Organizer
      The 65th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自己組織化技術を用いたマウスES細胞由来3次元唾液腺組織の誘導2017

    • Author(s)
      田中準一,中村史朗,安原理佳,井上富雄,美島健二
    • Organizer
      第62回日本唾液腺学会総会・学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 咬筋運動ニューロン樹状突起における興奮性シナプス入力のセロトニンによる増幅機構2017

    • Author(s)
      壇辻昌典,中村史朗,望月文子,中山希世美,尾関雅彦,井上富雄
    • Organizer
      日本顎口腔機能学会第59回学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 咬筋運動ニューロンへのシナプス入力に対するセロトニンの影響2017

    • Author(s)
      永田愛,中山希世美,中村史朗,望月文子,槇宏太郎,井上富雄
    • Organizer
      第64回昭和大学学士会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] マウス咬筋に対するシタロプラムの影響2017

    • Author(s)
      望月文子、池田美菜子、中村史朗、中山希世美、井上富雄
    • Organizer
      第11回三叉神経領域の感覚‐運動統合機構研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] The effects of Citalopram on the masseter muscle activity during non-REM sleep in mice.2017

    • Author(s)
      Ayako Mochizuki, Yasuha Ikawa, Takafumi Kato, Minako Ikeda, Shiro Nakamura, Kiyomi Nakayama, Kazuyoshi Baba, Tomio Inoue.
    • Organizer
      The 6th Annual International Institute for Integrative Sleep Medicine
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 咀嚼の神経メカニズム2017

    • Author(s)
      井上富雄
    • Organizer
      日本咀嚼学会第28回大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 歯周組織の生理学;ザ・ペリオドントロジー 第3版(沼部幸博、梅田誠、齋藤淳、山本松男編)2019

    • Author(s)
      井上富雄
    • Total Pages
      297
    • Publisher
      永末書店
    • Related Report
      2018 Annual Research Report
  • [Book] 顎口腔系の機能;新編 顎関節症 改訂版(日本顎関節学会編)2018

    • Author(s)
      井上富雄
    • Total Pages
      197
    • Publisher
      永末書店
    • Related Report
      2018 Annual Research Report
  • [Book] 筋電図法の基礎;新 よくわかる顎口腔機能 咬合・摂食嚥下・発音を理解する2017

    • Author(s)
      井上富雄
    • Total Pages
      287
    • Publisher
      医歯薬出版
    • Related Report
      2017 Research-status Report
  • [Book] 咀嚼の意義と効用;新 よくわかる顎口腔機能 咬合・摂食嚥下・発音を理解する2017

    • Author(s)
      井上富雄、中村史朗
    • Total Pages
      287
    • Publisher
      医歯薬出版
    • Related Report
      2017 Research-status Report
  • [Book] 咀嚼と脳 ― 咀嚼の中枢制御機構 ―;新 よくわかる顎口腔機能 咬合・摂食嚥下・発音を理解する2017

    • Author(s)
      井上富雄
    • Total Pages
      287
    • Publisher
      医歯薬出版
    • Related Report
      2017 Research-status Report
  • [Book] 日本顎関節学会学術用語集2017

    • Author(s)
      井上富雄ほか
    • Total Pages
      128
    • Publisher
      クインテッセンス出版
    • Related Report
      2017 Research-status Report
  • [Remarks] 昭和大学歯学部 口腔生理学講座 研究業績

    • URL

      http://www10.showa-u.ac.jp/~oralphys/gyoseki.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi