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The multicenter research regarding cessation of anticancer treatment for advanced lung cancer patients

Research Project

Project/Area Number 17K19785
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionTohoku University

Principal Investigator

Inoue Akira  東北大学, 医学系研究科, 教授 (70361087)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords緩和医療
Outline of Final Research Achievements

That this problem cancels anticancer drug treatment appropriately didn't affect the convalescence of the patient and in fact made the thing which contributes to QOL improvement a hypothesis. An observation study by a multicenter joint research group is begun targeted for the progress lung cancer patient taking molecular target medicine as the last treatment, and a case beyond 100 examples is accumulated and is continuing for 200 examples of a target in the present. The calculation and kou by which which is the medical cost after convalescence bad factor arrival, oh, it's made basic data of the positive intervention study which analyzes treatment continuation including an economic impact, and is after that. On the other hand it was possible to indicate the patient crowd who can think it's useful to do a retrospective study about the treatment reality of the end terminal cancer patient apart from the above observation study and receive chemotherapy in spite of the end period.

Academic Significance and Societal Importance of the Research Achievements

年々増えていく抗がん薬を「使い切る」ことが有益と多くの医師が盲目的に治療を続けていくことで、適切な終末期ケアに移行できずにQOLを損ねている患者、家族が多い。本研究の成果から、抗がん治療の適切な止め時が科学的に示されることで状況は改善され、「人生の最終段階」の質を高める国のがん対策にも合致する。また、高額な抗がん薬を適切に中止することは医療費の削減にもつながり社会的な意義も非常に高い。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2020 2019

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results)

  • [Journal Article] Phase II study of S-1 in patients with previously-treated invasive thymoma and thymic carcinoma: North Japan lung cancer study group trial 12032020

    • Author(s)
      Tsukita Yoko、Inoue Akira、Sugawara Shunichi、Kuyama Shoichi、Nakagawa Taku、Harada Daijiro、Tanaka Hisashi、Watanabe Kana、Mori Yoshiaki、Harada Toshiyuki、Hino Toshihiko、Fujii Masanori、Ichinose Masakazu
    • Journal Title

      Lung Cancer

      Volume: 139 Pages: 89-93

    • DOI

      10.1016/j.lungcan.2019.10.016

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study2020

    • Author(s)
      Hosomi Yukio、Morita Satoshi、Sugawara Shunichi、Kato Terufumi、Fukuhara Tatsuro、Gemma Akihiko、Takahashi Kazuhisa、Fujita Yuka、Harada Toshiyuki、Minato Koichi、Takamura Kei、Hagiwara Koichi、Kobayashi Kunihiko、Nukiwa Toshihiro、Inoue Akira、for the North-East Japan Study Group
    • Journal Title

      Journal of Clinical Oncology

      Volume: 38 Issue: 2 Pages: 115-123

    • DOI

      10.1200/jco.19.01488

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between health-related quality of life and achievement of personalized symptom goal.2020

    • Author(s)
      Tagami K, Kawaguchi T, Miura T, Yamaguchi T, Matsumoto Y, Watanabe YS, Uehara Y, Okizaki A, Inoue A, Morita T, Kinoshita H.
    • Journal Title

      Supportive Care in Cancer.

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients2020

    • Author(s)
      Sekine Ikuo、Shintani Yasushi、Shukuya Takehito、Takayama Koichi、Inoue Akira、Okamoto Isamu、Kiura Katsuyuki、Takahashi Kazuhisa、Dosaka‐Akita Hirotoshi、Takiguchi Yuichi、Miyaoka Etsuo、Okumura Meinoshin、Yoshino Ichiro
    • Journal Title

      Cancer Science

      Volume: - Issue: 5 Pages: 1685-1691

    • DOI

      10.1111/cas.14368

    • NAID

      120007159552

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas2019

    • Author(s)
      Tsukita Yoko、Fujino Naoya、Miyauchi Eisaku、Saito Ryoko、Fujishima Fumiyoshi、Itakura Koji、Kyogoku Yorihiko、Okutomo Koji、Yamada Mitsuhiro、Okazaki Tatsuma、Sugiura Hisatoshi、Inoue Akira、Okada Yoshinori、Ichinose Masakazu
    • Journal Title

      Molecular Cancer

      Volume: 18 Issue: 1 Pages: 24-24

    • DOI

      10.1186/s12943-019-0953-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Refractory Chest Pain Induced by Implantable Cardioverter-Defibrillator in a Patient with Advanced Cancer: What Is the Best Timing for Deactivation of an ICD?2019

    • Author(s)
      Hiratsuka Yusuke、Tagami Keita、Inoue Akira
    • Journal Title

      Journal of Palliative Medicine

      Volume: 22 Issue: 7 Pages: 745-746

    • DOI

      10.1089/jpm.2019.0126

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors in patients who received end-of-life chemotherapy for advanced cancer.2019

    • Author(s)
      Hiramoto S, Tamaki T, Nagashima K, Hori T, Kikuchi A, Yoshioka A, Inoue A.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 24 Pages: 454-459

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

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