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Comprehensive search for biomarkers predicting dementia using urine metabolomics analysis

Research Project

Project/Area Number 17K19799
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionNiigata University

Principal Investigator

Nakamura Kazutoshi  新潟大学, 医歯学系, 教授 (70207869)

Co-Investigator(Kenkyū-buntansha) 渡邊 裕美  新潟大学, 医歯学系, 講師 (50325479)
Co-Investigator(Renkei-kenkyūsha) IKEUCHI Takeshi  新潟大学, 医歯学系, 教授
YAMAMOTO Tadashi  新潟大学, 医歯学系, 特任教授
KABASAWA Keiko  新潟大学, 医歯学系, 特任助教
KITAMURA Kaori  新潟大学, 医歯学系, 助教
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsアルツハイマー病 / メタボロミクス / 尿 / バイオマーカー / 予防 / 認知症 / 二次予防
Outline of Final Research Achievements

This study aimed to determine specific urine biomarkers of Alzheimer disease (AD) by using metabolomics. Urine samples of 9 AD patients and 9 controls were analyzed with predictive model and validation model. Two and 7 metabolites were increased and decreased, respectively in predictive model, and 3 and 6 metabolites, respectively, were in validation model. Especially, glycerol-3-phosphate was significantly decreased in the both model. It is suggested that urine glycerol-3-phosphate is a new biomarker.

Academic Significance and Societal Importance of the Research Achievements

本研究で見出された尿中glycerol-3-phosphateは、アルツハイマー病の新たなバイオマーカーの可能性があり、尿でアルツハイマー病が予測できることが期待される。また同時に、glycerol-3-phosphateが減少したことはアルツハイマー病におけるリン脂質代謝の異常を反映している可能性がある。今後は尿中の脂溶性代謝産物の変化についての解析を行うことが重要と考える。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (1 results)

All Other

All Remarks (1 results)

  • [Remarks] 新潟大学大学院医歯学総合研究科環境予防医学分野

    • URL

      https://www.med.niigata-u.ac.jp/hyg/index.html

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-21   Modified: 2020-03-30  

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