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Exploration of microRNA to evaluate the risk of low birth weight associated with maternal smoking

Research Project

Project/Area Number 17K19806
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionUniversity of Fukui (2018-2019)
Mie University (2017)

Principal Investigator

Hiraku Yusuke  福井大学, 学術研究院医学系部門, 教授 (30324510)

Co-Investigator(Kenkyū-buntansha) 岸 玲子  北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449)
佐田 文宏  中央大学, 保健センター, 嘱託職員 (90187154)
Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords喫煙 / 低体重出生 / マイクロRNA / リスク評価 / 慢性疾患 / DOHaD / バイオマーカー
Outline of Final Research Achievements

The proportion of births with low body weight has been increasing in recent years in Japan, and maternal smoking is one of the most important causes. Previous epidemiological studies have demonstrated that fetal growth retardation is a risk factor of a number of chronic diseases, such as diabetes and heart diseases, in later life. In this study, we performed comprehensive microRNA (miRNA) analysis in the plasma of pregnant women using microarrays, and investigated the association with maternal smoking and the correlation with birth body weight. Although no miRNAs were found to be affected by maternal smoking, the levels of three miRNAs were significantly correlated with birth body weight. These results raise a possibility that these miRNAs can be used to evaluate the risk of low birth body weight and future risk of chronic diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、妊娠女性の血液中のmiRNAに着目することにより、従来の発想と異なるエピゲノム変化に基づいた疾病のリスク評価に資する知見を得た点で学術的意義がある。また、本研究で見いだしたmiRNAは、環境因子に起因する疾病のリスクを予測するバイオマーカーとしての可能性が期待され、その成果をヒト集団に還元して出生前の時期を含むライフコース医学を創成し、母子保健に寄与できるという点で社会的意義がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (42 results)

All 2020 2019 2018 2017 Other

All Journal Article (19 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 19 results,  Open Access: 15 results) Presentation (21 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] Pathway linking physical activity, sleep duration, and breakfast consumption with the physical/psychosocial health of schoolchildren2019

    • Author(s)
      Sawa S, Hashizume K, Abe T, Kusaka Y, Fukazawa Y, Hiraku Y, Hagihara A
    • Journal Title

      J Child Health Care

      Volume: - Issue: 1 Pages: 5-17

    • DOI

      10.1177/1367493519891019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells2019

    • Author(s)
      He Feng、Ma Ning、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Mo Yingxi、Zhang Zhe、Takeuchi Kazuhiko、Murata Mariko
    • Journal Title

      Adv Exp Med Biol

      Volume: 2019;1155:533-541 Pages: 533-541

    • DOI

      10.1007/978-981-13-8023-5_49

    • ISBN
      9789811380228, 9789811380235
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxidative DNA damage and apoptosis induced by aclarubicin, an anthracycline: role of hydrogen peroxide and copper.2019

    • Author(s)
      Mizutani H, Hayashi Y, Hashimoto M, Imai M, Ichimaru Y, Kitamura Y, Ikemura K, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S
    • Journal Title

      Anticancer Res

      Volume: 39 Issue: 7 Pages: 3443-3451

    • DOI

      10.21873/anticanres.13490

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal tobacco exposure and ADHD symptoms at pre-school age: the Hokkaido Study on Environment and Children’s Health2019

    • Author(s)
      Minatoya M, Araki A, Itoh S, Yamazaki K, Kobayashi S, Miyashita C, Sasaki S, Kishi R
    • Journal Title

      Environ Health Prev Med

      Volume: 24 Issue: 1 Pages: 74-74

    • DOI

      10.1186/s12199-019-0834-4

    • NAID

      50014276980

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation2019

    • Author(s)
      Mori Yurie、Kato Shinya、Fujisawa Yutaka、Ohnishi Shiho、Hiraku Yusuke、Kawanishi Shosuke、Murata Mariko、Oikawa Shinji
    • Journal Title

      Free Radical Research

      Volume: 53 Issue: 1 Pages: 115-123

    • DOI

      10.1080/10715762.2018.1562179

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation2018

    • Author(s)
      Suwannakul Nattawan、Ma Ning、Thanan Raynoo、Pinlaor Somchai、Ungarreevittaya Piti、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Kawanishi Shosuke、Murata Mariko
    • Journal Title

      Mediators of Inflammation

      Volume: 2018 Pages: 1-8

    • DOI

      10.1155/2018/4867234

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxidative DNA damage induced by pirarubicin, an anthracycline anticancer agent, in the presence of copper(II).2018

    • Author(s)
      Mizutani H, Nishimoto A, Hotta S, Ikemura K, Imai M, Miyazawa D, Ohta K, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 5 Pages: 2643-2648

    • DOI

      10.21873/anticanres.12506

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteomic profiling of exosomal proteins for blood-based biomarkers in Parkinson's Disease.2018

    • Author(s)
      Kitamura Y, Kojima M, Kurosawa T, Sasaki R, Ichihara S, Hiraku Y, Tomimoto H, Murata M, Oikawa S.
    • Journal Title

      Neuroscience

      Volume: 392 Pages: 121-128

    • DOI

      10.1016/j.neuroscience.2018.09.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro2018

    • Author(s)
      He Feng、Ma Ning、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Zhang Zhe、Huang Guangwu、Takeuchi Kazuhiko、Murata Mariko
    • Journal Title

      Amino Acids

      Volume: 50 Issue: 12 Pages: 1749-1758

    • DOI

      10.1007/s00726-018-2651-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Environmental Factors and MicroRNA: Application for DOHaD Research and Future Perspectives2018

    • Author(s)
      平工雄介
    • Journal Title

      Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

      Volume: 73 Issue: 2 Pages: 105-109

    • DOI

      10.1265/jjh.73.105

    • NAID

      130007378538

    • ISSN
      0021-5082, 1882-6482
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nitrative DNA damage in cultured macrophages exposed to indium oxide2018

    • Author(s)
      Afroz T, Hiraku Y, Ma N, Ahmed S, Oikawa S, Kawanishi S, Murata M
    • Journal Title

      Journal of Occupational Health

      Volume: 60 Issue: 2 Pages: 148-155

    • DOI

      10.1539/joh.17-0146-OA

    • NAID

      130006565471

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanism of oxidative DNA damage induced by metabolites of carcinogenic naphthalene2018

    • Author(s)
      Ohnishi Shiho、Hiraku Yusuke、Hasegawa Keishi、Hirakawa Kazutaka、Oikawa Shinji、Murata Mariko、Kawanishi Shosuke
    • Journal Title

      Mutat Res.

      Volume: 827 Pages: 42-49

    • DOI

      10.1016/j.mrgentox.2018.01.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA22018

    • Author(s)
      Hou Bo、Ishinaga Hajime、Midorikawa Kaoru、Nakamura Satoshi、Hiraku Yusuke、Oikawa Shinji、Ma Ning、Takeuchi Kazuhiko、Murata Mariko
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 10 Pages: 8927-8940

    • DOI

      10.18632/oncotarget.23826

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells2017

    • Author(s)
      Hiraku Y, Nishikawa Y, Ma N, Afroz T, Mizobuchi K, Ishiyama R, Matsunaga Y, Ichinose T, Kawanishi S, Murata S.
    • Journal Title

      Mutat Res Gen Tox En.

      Volume: 818 Pages: 7-16

    • DOI

      10.1016/j.mrgentox.2017.04.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitation of DNA methylation in Epstein-Barr virus?associated nasopharyngeal carcinoma by bisulfite amplicon sequencing2017

    • Author(s)
      Zhao Weilin、Mo Yingxi、Wang Shumin、Midorikawa Kaoru、Ma Ning、Hiraku Yusuke、Oikawa Shinji、Huang Guangwu、Zhang Zhe、Murata Mariko、Takeuchi Kazuhiko
    • Journal Title

      BMC Cancer

      Volume: 17 Issue: 1 Pages: 489-489

    • DOI

      10.1186/s12885-017-3482-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma2017

    • Author(s)
      Zhao Weilin、Ma Ning、Wang Shumin、Mo Yingxi、Zhang Zhe、Huang Guangwu、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Murata Mariko、Takeuchi Kazuhiko
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 36 Issue: 1 Pages: 88-88

    • DOI

      10.1186/s13046-017-0554-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gene expression profiling of hepatocarcinogenesis in a mouse model of chronic hepatitis B2017

    • Author(s)
      Nosaka Takuto、Naito Tatsushi、Hiramatsu Katsushi、Ohtani Masahiro、Nemoto Tomoyuki、Marusawa Hiroyuki、Ma Ning、Hiraku Yusuke、Kawanishi Shosuke、Yamashita Taro、Kaneko Shuichi、Nakamoto Yasunari
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 10 Pages: e0185442-e0185442

    • DOI

      10.1371/journal.pone.0185442

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pirarubicin, an Anthracycline Anticancer Agent, Induces Apoptosis Through Generation of Hydrogen Peroxide.2017

    • Author(s)
      Mizutani H, Hotta S, Nishimoto A, Ikemura K, Miyazawa D, Ikeda Y, Maeda T, Yoshikawa M, Hiraku Y, Kawanishi S.
    • Journal Title

      Anticancer Res.

      Volume: 37 Issue: 11 Pages: 6063-6069

    • DOI

      10.21873/anticanres.12054

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis2017

    • Author(s)
      Kawanishi Shosuke、Ohnishi Shiho、Ma Ning、Hiraku Yusuke、Murata Mariko
    • Journal Title

      Int J Mol Sci.

      Volume: 18 Issue: 8 Pages: 1808-1808

    • DOI

      10.3390/ijms18081808

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] インジウム化合物に曝露した肺上皮細胞における炎症反応を介したニトロ化DNA損傷2020

    • Author(s)
      Sharif Ahmed、小林果、Tahmina Afroz、馬寧、及川伸二、川西正祐、 村田真理子、平工雄介
    • Organizer
      第90回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] インジウム化合物によるヒト肺上皮細胞におけるニトロ化DNA損傷2019

    • Author(s)
      平工雄介、村田真理子
    • Organizer
      第92回日本産業衛生学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 環境因子によるマイクロRNAの発現変動:DOHaD研究への応用と展望2019

    • Author(s)
      平工雄介
    • Organizer
      第13回DOHaD疫学セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 環境発がんにおける酸化・ニトロ化DNA損傷2019

    • Author(s)
      平工雄介
    • Organizer
      第51回藤田学園医学会シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] (若手自由集会、日本医学会連合加盟学会連携フォーラム) タイ肝吸虫感染による胆管癌の予防を目指した国際共同研究2019

    • Author(s)
      平工雄介
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Nitrative DNA damage in lung epithelial cells exposed to particulate and soluble indium compounds (肺上皮細胞における粒子状および水溶性インジウム化合物によるニトロ化DNA損傷)2019

    • Author(s)
      Sharif Ahmed, Tahmina Afroz, 馬寧、川西正祐、村田真理子、平工雄介
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] RERG hypermethylation in circulating cell-free DNA of nasopharyngeal carcinoma: a potential hematological marker for screening2019

    • Author(s)
      Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Taurine exhibits an anti-proliferation effect on human nasopharyngeal carcinoma cells in vivo2019

    • Author(s)
      Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 抗がん性抗生物質アクラルビシンによる酸化的DNA損傷と細胞死2019

    • Author(s)
      水谷秀樹、橋本未耶美、平工雄介、川西正祐
    • Organizer
      日本酸化ストレス学会東海支部第7回学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] GDF10 is a candidate tumor suppressor gene inactivated by promoter hypermethylation in human nasopharyngeal carcinoma2018

    • Author(s)
      Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] A novel cancer stem cell biomarker CD44v9 in liver fluke-related cholangiocarcinoma2018

    • Author(s)
      Nattawan Suwannakul, Ning Ma, Raynoo Thanan, Somchai Pinlaor, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata.
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] DNA methylation in circulating cell-free DNA of nasopharyngeal carcinoma2018

    • Author(s)
      Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 石綿曝露マウスの肺組織におけるマイクロRNAと標的遺伝子発現の解析2018

    • Author(s)
      平工雄介、村田真理子
    • Organizer
      第91回日本産業衛生学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Taurine induces Apoptosis in Human Nasopharyngeal Carcinoma Cells through PTEN-mediated inhibition of Akt pathway in Vitro.2018

    • Author(s)
      Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      The 21st International Taurine Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Nitrative DNA damage in lung epithelial cells exposed to indium compounds2018

    • Author(s)
      Sharif Ahmed, Tahmina Afroz, 馬寧、川西正祐、村田真理子、平工雄介
    • Organizer
      第88回日本衛生学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Taurine inhibits proliferation and colony formation in nasopharyngeal carcinoma cells2018

    • Author(s)
      何峰、馬寧、翠川薫、平工雄介、及川伸二、村田真理子
    • Organizer
      第88回日本衛生学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Novel epigenetic markers for Epstein-Barr virus-associated nasopharyngeal carcinoma2018

    • Author(s)
      Yifei Xu、馬寧、翠川薫、平工雄介、及川伸二、村田真理子
    • Organizer
      第88回日本衛生学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Expression of a novel cancer stem cell biomarker, CD44 variant 9, in human cholangiocarcinoma2018

    • Author(s)
      Nattawan Suwannakul, 馬寧、翠川薫、平工雄介、及川伸二、川西正祐、村田真理子
    • Organizer
      第88回日本衛生学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] インジウム曝露ラット肺における炎症関連分子S100蛋白とリポカリン2の解析2017

    • Author(s)
      平工雄介、山本雅人、中谷穂、小林真悠、田中昭代、平田美由紀、村田真理子
    • Organizer
      日本産業衛生学会東海地方会学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Nitrative DNA damage in cultured cells exposed to indium compounds2017

    • Author(s)
      Sharif Ahmed, Tahmina Afroz、馬寧、及川伸二、川西正祐、村田真理子、平工雄介
    • Organizer
      第63回東海公衆衛生学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] インジウム曝露ラット肺における炎症関連分子の解析(優秀演題賞)2017

    • Author(s)
      平工雄介、田中昭代、平田美由紀、村田真理子
    • Organizer
      第90回日本産業衛生学会
    • Related Report
      2017 Research-status Report
  • [Remarks] 福井大学医学部 環境保健学分野

    • URL

      https://www.med.u-fukui.ac.jp/laboratory/environmental/

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Remarks] 三重大学大学院医学系研究科 環境分子医学分野

    • URL

      http://www.medic.mie-u.ac.jp/eiseigaku/

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

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