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Personalized therapies through RCT big data: IPD meta-analyses

Research Project

Project/Area Number 17K19808
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionKyoto University

Principal Investigator

Furukawa Toshiaki  京都大学, 医学研究科, 教授 (90275123)

Co-Investigator(Kenkyū-buntansha) 渡辺 範雄  京都大学, 医学研究科, 客員研究員 (20464563)
田中 司朗  京都大学, 医学研究科, 特定教授 (60522406)
野間 久史  統計数理研究所, データ科学研究系, 准教授 (70633486)
Project Period (FY) 2017-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsうつ病 / メタアナリシス / 臨床疫学 / 社会医学
Outline of Final Research Achievements

We have been able to assemble several datasets of IPD, and have published eight IPD (network) meta-analyses as well as four methodological papers in international journals.

Academic Significance and Societal Importance of the Research Achievements

既存の臨床試験の個人データを集積したビッグデータの解析により、個別化医療を進めることは、現在の医学における重要課題の一つである。われわれは主にうつ病について個人データ(ネットワーク)メタアナリシスを8本出版することによってこの方面の知見の進歩に貢献したのみならず、方法論的論文も4本出版して分野の進歩に寄与した。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (11 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 10 results,  Open Access: 3 results)

  • [Int'l Joint Research] アムステルダム自由大学(オランダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ベルン大学(スイス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of Oxford(英国)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ベルン大学(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] フライブルク大学(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] オックスフォード大学(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Oxford(United Kingdom)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Internet-Based Cognitive Behavioral Therapy for Depression2021

    • Author(s)
      Karyotaki Eirini、Efthimiou Orestis、Miguel Clara、Bermpohl Frederic Maas genannt、Furukawa Toshi A.、Cuijpers Pim、Individual Patient Data Meta-Analyses for Depression (IPDMA-DE) Collaboration
    • Journal Title

      JAMA Psychiatry

      Volume: - Issue: 4 Pages: 361-361

    • DOI

      10.1001/jamapsychiatry.2020.4364

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Melancholic features (DSM-IV) predict but do not moderate response to antidepressants in major depression: an individual participant data meta-analysis of 1219 patients2020

    • Author(s)
      Imai Hissei、Noma Hisashi、Furukawa Toshi A.
    • Journal Title

      European Archives of Psychiatry and Clinical Neuroscience

      Volume: 271 Issue: 3 Pages: 521-526

    • DOI

      10.1007/s00406-020-01173-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting antidepressant response through early improvement of individual symptoms of depression incorporating baseline characteristics of patients: An individual patient data meta-analysis2020

    • Author(s)
      Watanabe Norio、Maruo Kazushi、Imai Hissei、Ikeda Kazutaka、Yamawaki Shigeto、Furukawa Toshi A.
    • Journal Title

      Journal of Psychiatric Research

      Volume: 125 Pages: 85-90

    • DOI

      10.1016/j.jpsychires.2020.03.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparing methods for estimating patient‐specific treatment effects in individual patient data meta‐analysis2020

    • Author(s)
      Seo Michael、White Ian R.、Furukawa Toshi A.、Imai Hissei、Valgimigli Marco、Egger Matthias、Zwahlen Marcel、Efthimiou Orestis
    • Journal Title

      Statistics in Medicine

      Volume: 40 Issue: 6 Pages: 1553-1573

    • DOI

      10.1002/sim.8859

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Permutation inference methods for multivariate meta‐analysis2019

    • Author(s)
      Noma Hisashi、Nagashima Kengo、Furukawa Toshi A.
    • Journal Title

      Biometrics

      Volume: 76 Issue: 1 Pages: 337-347

    • DOI

      10.1111/biom.13134

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data2019

    • Author(s)
      Shinohara Kiyomi、Tanaka Shiro、Imai Hissei、Noma Hisashi、Maruo Kazushi、Cipriani Andrea、Yamawaki Shigeto、Furukawa Toshi A
    • Journal Title

      Evidence Based Mental Health

      Volume: 22 Issue: 1 Pages: 10-16

    • DOI

      10.1136/ebmental-2018-300073

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models2019

    • Author(s)
      Noma, H., Maruo, K., Gosho, M., Levine, S. Z., Goldberg, Y., Leucht, S., Furukawa, T. A.
    • Journal Title

      BMC Medical Research Methodology

      Volume: 19 Issue: 1 Pages: 33-33

    • DOI

      10.1186/s12874-019-0676-1

    • NAID

      120007127948

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exploratory analyses of effect modifiers in the antidepressant treatment of major depression: Individual-participant data meta-analysis of 2803 participants in seven placebo-controlled randomized trials2019

    • Author(s)
      Noma, H., Furukawa, T. A., Maruo, K., Imai, H., Shinohara, K., Tanaka, S., Ikeda, K., Yamawaki, S., Cipriani, A.
    • Journal Title

      Journal of Affective Disorders

      Volume: 250 Pages: 419-424

    • DOI

      10.1016/j.jad.2019.03.031

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cognitive-Behavioral Analysis System of Psychotherapy, Drug, or Their Combination for Persistent Depressive Disorder: Personalizing the Treatment Choice Using Individual Participant Data Network Metaregression2018

    • Author(s)
      Furukawa Toshi?A.、Efthimiou Orestis、Weitz Erica?S.、Cipriani Andrea、Keller Martin?B.、Kocsis James?H.、Klein Daniel?N.、Michalak Johannes、Salanti Georgia、Cuijpers Pim、Schramm Elisabeth
    • Journal Title

      Psychotherapy and Psychosomatics

      Volume: 87 Issue: 3 Pages: 140-153

    • DOI

      10.1159/000489227

    • Related Report
      2018 Research-status Report
  • [Journal Article] Initial severity of major depression and efficacy of new generation antidepressants: Individual-participant data meta-analysis2018

    • Author(s)
      Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S & Cipriani A
    • Journal Title

      Acta Psychiatrica Scandinavica

      Volume: epub Issue: 6 Pages: 1-8

    • DOI

      10.1111/acps.12886

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative efficacy and acceptability of first- and second-generation antidepressants in the acute treatment of major depressive disorder: A network meta-analysis.2018

    • Author(s)
      Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JP, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JP & Geddes JR
    • Journal Title

      Lancet

      Volume: epub Issue: 10128 Pages: 1-8

    • DOI

      10.1016/s0140-6736(17)32802-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2017-07-21   Modified: 2022-01-27  

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