Personalized therapies through RCT big data: IPD meta-analyses

• Project/Area Number: 17K19808
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Society medicine, Nursing, and related fields
• Research Institution: Kyoto University
• Principal Investigator: Furukawa Toshiaki 京都大学, 医学研究科, 教授 (90275123)
• Co-Investigator(Kenkyū-buntansha): 渡辺 範雄 京都大学, 医学研究科, 客員研究員 (20464563) ; 田中 司朗 京都大学, 医学研究科, 特定教授 (60522406) ; 野間 久史 統計数理研究所, データ科学研究系, 准教授 (70633486)
• Project Period (FY): 2017-06-30 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: うつ病 / メタアナリシス / 臨床疫学 / 社会医学

Outline of Final Research Achievements

We have been able to assemble several datasets of IPD, and have published eight IPD (network) meta-analyses as well as four methodological papers in international journals.

Academic Significance and Societal Importance of the Research Achievements

既存の臨床試験の個人データを集積したビッグデータの解析により、個別化医療を進めることは、現在の医学における重要課題の一つである。われわれは主にうつ病について個人データ（ネットワーク）メタアナリシスを8本出版することによってこの方面の知見の進歩に貢献したのみならず、方法論的論文も4本出版して分野の進歩に寄与した。

Research Products

• [Int'l Joint Research] アムステルダム自由大学(オランダ)
• [Int'l Joint Research] ベルン大学(スイス)
• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] ベルン大学(英国)
• [Int'l Joint Research] フライブルク大学(ドイツ)
• [Int'l Joint Research] オックスフォード大学(英国)
• [Int'l Joint Research] University of Oxford(United Kingdom)
• [Journal Article] Internet-Based Cognitive Behavioral Therapy for Depression (2021)
  • Author(s): Karyotaki Eirini、Efthimiou Orestis、Miguel Clara、Bermpohl Frederic Maas genannt、Furukawa Toshi A.、Cuijpers Pim、Individual Patient Data Meta-Analyses for Depression (IPDMA-DE) Collaboration
  • Journal Title: JAMA Psychiatry Volume: - Issue: 4 Pages: 361-361
  • DOI: 10.1001/jamapsychiatry.2020.4364
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Melancholic features (DSM-IV) predict but do not moderate response to antidepressants in major depression: an individual participant data meta-analysis of 1219 patients (2020)
  • Author(s): Imai Hissei、Noma Hisashi、Furukawa Toshi A.
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience Volume: 271 Issue: 3 Pages: 521-526
  • DOI: 10.1007/s00406-020-01173-4
  • Peer Reviewed
• [Journal Article] Predicting antidepressant response through early improvement of individual symptoms of depression incorporating baseline characteristics of patients: An individual patient data meta-analysis (2020)
  • Author(s): Watanabe Norio、Maruo Kazushi、Imai Hissei、Ikeda Kazutaka、Yamawaki Shigeto、Furukawa Toshi A.
  • Journal Title: Journal of Psychiatric Research Volume: 125 Pages: 85-90
  • DOI: 10.1016/j.jpsychires.2020.03.009
  • Peer Reviewed
• [Journal Article] Comparing methods for estimating patient‐specific treatment effects in individual patient data meta‐analysis (2020)
  • Author(s): Seo Michael、White Ian R.、Furukawa Toshi A.、Imai Hissei、Valgimigli Marco、Egger Matthias、Zwahlen Marcel、Efthimiou Orestis
  • Journal Title: Statistics in Medicine Volume: 40 Issue: 6 Pages: 1553-1573
  • DOI: 10.1002/sim.8859
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Permutation inference methods for multivariate meta‐analysis (2019)
  • Author(s): Noma Hisashi、Nagashima Kengo、Furukawa Toshi A.
  • Journal Title: Biometrics Volume: 76 Issue: 1 Pages: 337-347
  • DOI: 10.1111/biom.13134
  • Peer Reviewed
• [Journal Article] Development and validation of a prediction model for the probability of responding to placebo in antidepressant trials: a pooled analysis of individual patient data (2019)
  • Author(s): Shinohara Kiyomi、Tanaka Shiro、Imai Hissei、Noma Hisashi、Maruo Kazushi、Cipriani Andrea、Yamawaki Shigeto、Furukawa Toshi A
  • Journal Title: Evidence Based Mental Health Volume: 22 Issue: 1 Pages: 10-16
  • DOI: 10.1136/ebmental-2018-300073
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models (2019)
  • Author(s): Noma, H., Maruo, K., Gosho, M., Levine, S. Z., Goldberg, Y., Leucht, S., Furukawa, T. A.
  • Journal Title: BMC Medical Research Methodology Volume: 19 Issue: 1 Pages: 33-33
  • DOI: 10.1186/s12874-019-0676-1
  • NAID: 120007127948
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exploratory analyses of effect modifiers in the antidepressant treatment of major depression: Individual-participant data meta-analysis of 2803 participants in seven placebo-controlled randomized trials (2019)
  • Author(s): Noma, H., Furukawa, T. A., Maruo, K., Imai, H., Shinohara, K., Tanaka, S., Ikeda, K., Yamawaki, S., Cipriani, A.
  • Journal Title: Journal of Affective Disorders Volume: 250 Pages: 419-424
  • DOI: 10.1016/j.jad.2019.03.031
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cognitive-Behavioral Analysis System of Psychotherapy, Drug, or Their Combination for Persistent Depressive Disorder: Personalizing the Treatment Choice Using Individual Participant Data Network Metaregression (2018)
  • Author(s): Furukawa Toshi?A.、Efthimiou Orestis、Weitz Erica?S.、Cipriani Andrea、Keller Martin?B.、Kocsis James?H.、Klein Daniel?N.、Michalak Johannes、Salanti Georgia、Cuijpers Pim、Schramm Elisabeth
  • Journal Title: Psychotherapy and Psychosomatics Volume: 87 Issue: 3 Pages: 140-153
  • DOI: 10.1159/000489227
• [Journal Article] Initial severity of major depression and efficacy of new generation antidepressants: Individual-participant data meta-analysis (2018)
  • Author(s): Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S & Cipriani A
  • Journal Title: Acta Psychiatrica Scandinavica Volume: epub Issue: 6 Pages: 1-8
  • DOI: 10.1111/acps.12886
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparative efficacy and acceptability of first- and second-generation antidepressants in the acute treatment of major depressive disorder: A network meta-analysis. (2018)
  • Author(s): Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JP, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JP & Geddes JR
  • Journal Title: Lancet Volume: epub Issue: 10128 Pages: 1-8
  • DOI: 10.1016/s0140-6736(17)32802-7
  • Peer Reviewed / Open Access / Int'l Joint Research