Epidemiological study on the elaboration of the prediction of cerebral infarction by autoantibody markers
| Project/Area Number |
17K19810
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Society medicine, Nursing, and related fields
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| Research Institution | Osaka University |
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Principal Investigator |
Iso Hiroyasu 大阪大学, 医学系研究科, 教授 (50223053)
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| Co-Investigator(Kenkyū-buntansha) |
山岸 良匡 筑波大学, 医学医療系, 教授 (20375504)
日和佐 隆樹 千葉大学, 大学院医学研究院, 特任准教授 (30260251)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 予防医学 / 疫学 / 症例対照研究 / 自己抗体マーカー / 脳梗塞 / 解析・評価 / 脳神経疾患 |
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| Outline of Final Research Achievements |
The antibody levels of candidate markers of atherosclerosis in past cryopreserved plasma were measured with high throughput using AlphaLISA, a high-sensitivity ELISA, and the association with the incidence of cerebral infarction (CI) was analyzed using the nested case-control study method in cases of CI, the most common atherosclerotic disease in Japan, and controls in the general population. We found several antibodies which may be used as predictive markers of CI incidence. A patent is pending for some markers that were found to be of particular relevance.
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| Academic Significance and Societal Importance of the Research Achievements |
血清自己抗体は個人の病歴を反映しており、疾患が発症する前に存在する抗体が明らかになれば、疾患の発症予測マーカーとしての活用が期待される。既にがんや自己免疫疾患については特異的な自己抗体が出現することが報告されているが、動脈硬化性疾患については自己抗体が関与するという着想はこれまで乏しく、厳密な疫学手法を用いた脳梗塞の発症に関与する自己抗体マーカーの包括的な解明は皆無であった。本研究において、脳梗塞の発症前の血清中に特異的に存在する抗体が複数同定されたことから、これらの抗体を発症予測マーカーとして活用することで脳梗塞の前駆病態の早期発見・早期治療に繋げることが期待される。
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease2020
Author(s)
Yoshizaki T, Ishihara J, Kotemori A, Yamamoto J, Kokubo Y, Saito I, Yatsuya H, Yamagishi K, Sawada N, Iwasaki M, Iso H, Tsugane S; JPHC Study Group
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Journal Title
Journal of Epidemiology
Volume: 30
Issue: 1
Pages: 37-45
DOI
NAID
ISSN
0917-5040, 1349-9092
Year and Date
2020-01-05
Related Report
Peer Reviewed
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[Journal Article] Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study2019
Author(s)
Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A.
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Journal Title
Journal of Epidemiology
Volume: 29
Issue: 9
Pages: 325-333
DOI
NAID
ISSN
0917-5040, 1349-9092
Year and Date
2019-09-05
Related Report
Peer Reviewed / Open Access
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[Journal Article] Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study2019
Author(s)
Murai U, Yamagishi K, Sata M, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Sawada N, Iso H, Tsugane S; JPHC Study Group
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Journal Title
Am J Clin Nutr
Volume: 110
Issue: 6
Pages: 1449-1455
DOI
NAID
Related Report
Peer Reviewed
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