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Epidemiological study on the elaboration of the prediction of cerebral infarction by autoantibody markers

Research Project

Project/Area Number 17K19810
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Society medicine, Nursing, and related fields
Research InstitutionOsaka University

Principal Investigator

Iso Hiroyasu  大阪大学, 医学系研究科, 教授 (50223053)

Co-Investigator(Kenkyū-buntansha) 山岸 良匡  筑波大学, 医学医療系, 教授 (20375504)
日和佐 隆樹  千葉大学, 大学院医学研究院, 特任准教授 (30260251)
Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords予防医学 / 疫学 / 症例対照研究 / 自己抗体マーカー / 脳梗塞 / 解析・評価 / 脳神経疾患
Outline of Final Research Achievements

The antibody levels of candidate markers of atherosclerosis in past cryopreserved plasma were measured with high throughput using AlphaLISA, a high-sensitivity ELISA, and the association with the incidence of cerebral infarction (CI) was analyzed using the nested case-control study method in cases of CI, the most common atherosclerotic disease in Japan, and controls in the general population. We found several antibodies which may be used as predictive markers of CI incidence. A patent is pending for some markers that were found to be of particular relevance.

Academic Significance and Societal Importance of the Research Achievements

血清自己抗体は個人の病歴を反映しており、疾患が発症する前に存在する抗体が明らかになれば、疾患の発症予測マーカーとしての活用が期待される。既にがんや自己免疫疾患については特異的な自己抗体が出現することが報告されているが、動脈硬化性疾患については自己抗体が関与するという着想はこれまで乏しく、厳密な疫学手法を用いた脳梗塞の発症に関与する自己抗体マーカーの包括的な解明は皆無であった。本研究において、脳梗塞の発症前の血清中に特異的に存在する抗体が複数同定されたことから、これらの抗体を発症予測マーカーとして活用することで脳梗塞の前駆病態の早期発見・早期治療に繋げることが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Association of Vegetable, Fruit, and Okinawan Vegetable Consumption With Incident Stroke and Coronary Heart Disease2020

    • Author(s)
      Yoshizaki T, Ishihara J, Kotemori A, Yamamoto J, Kokubo Y, Saito I, Yatsuya H, Yamagishi K, Sawada N, Iwasaki M, Iso H, Tsugane S; JPHC Study Group
    • Journal Title

      Journal of Epidemiology

      Volume: 30 Issue: 1 Pages: 37-45

    • DOI

      10.2188/jea.JE20180130

    • NAID

      130007782483

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2020-01-05
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study2019

    • Author(s)
      Yatsuya H, Li Y, Hirakawa Y, Ota A, Matsunaga M, Haregot HE, Chiang C, Zhang Y, Tamakoshi K, Toyoshima H, Aoyama A.
    • Journal Title

      Journal of Epidemiology

      Volume: 29 Issue: 9 Pages: 325-333

    • DOI

      10.2188/jea.JE20170298

    • NAID

      130007703036

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2019-09-05
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men ― The Japan Public Health Center-Based Prospective Study Cohort II ―2019

    • Author(s)
      Hayashi R, Iso H, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Eshak ES, Sawada N, Tsugane S; Japan Public Health Center-Based (JPHC) Prospective Study Group
    • Journal Title

      Circulation Journal

      Volume: 83 Issue: 5 Pages: 1072-1079

    • DOI

      10.1253/circj.CJ-18-0842

    • NAID

      130007636889

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2019-04-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study2019

    • Author(s)
      Murai U, Yamagishi K, Sata M, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Sawada N, Iso H, Tsugane S; JPHC Study Group
    • Journal Title

      Am J Clin Nutr

      Volume: 110 Issue: 6 Pages: 1449-1455

    • DOI

      10.1093/ajcn/nqz231

    • NAID

      120007133031

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Patent(Industrial Property Rights)] 脳梗塞の診断マーカー2018

    • Inventor(s)
      後藤憲一郎、日和佐隆樹、松村竜太郎、杉山隆夫
    • Industrial Property Rights Holder
      日和佐隆樹
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-050502
    • Filing Date
      2018
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2017-07-21   Modified: 2021-02-19  

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