• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The neural mechanism of anxiety related long-term potentiation

Research Project

Project/Area Number 17K19879
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Health science and related fields
Research InstitutionHyogo Medical University

Principal Investigator

KOGA KOHEI  兵庫医科大学, 医学部, 講師 (50768455)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsシナプス長期増強 / 情動 / 前帯状回 / 慢性疼痛 / シナプス可塑性 / 不安
Outline of Final Research Achievements

The anterior cingulate cortex (ACC) is a critical cortical area for various emotions, especially anxiety like behaviors. We focused on the presynaptic long-term potentiation (pre-LTP) that occurs to glutamatergic transmission in the ACC, and studied the detailed molecular mechanisms related to anxiety-like behaviors. Since an ubiquitin proteasome system (UPS) plays the role for the degradation of protein, we considered the UPS necessary for the cortical pre-LTP. Bath application of a proteasome inhibitor MG-132 inhibited the cortical pre-LTP. However, MG-132 did not affect basal synaptic transmission. An ubiquitin ligase E3, SCRRAPER knockout mice reduced pre-LTP. Furthermore, noradrenaline produced synaptic plasticity on glutamatergic transmission. These results suggest that the pre-LTP in the ACC which is related to anxiety like behaviors requires the UPS, especially through SCRAPPER.

Academic Significance and Societal Importance of the Research Achievements

前帯状回は、情動の形成に重要な役割を果たす大脳皮質であり、不安に関与することがヒトイメージングで明らかになっている。我々が明らかにしたシナプスレベルの解析では、前帯状回のpre-LTPは興奮性神経伝達物質であるグルタミン酸の放出を促進することから、この神経伝達物質の放出が不安様行動の形成に関わる可能性が考えられる。本研究でpre-LTPやシナプス可塑性を制御する機構の詳細が明らかになると、不安障害や慢性疼痛による不安の増悪に対する創薬や治療法の開発につながっていく。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (17 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] Xi’an Jiaotong University/Air Force Medical University/Nat Inst Biol Sci(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Toronto(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex.2020

    • Author(s)
      Koga K, Yamada A, Song Q, Li XH, Chen QY, Liu RH, Ge J, Zhan C, Furue H, Zhuo M, Chen T.
    • Journal Title

      Mol Brain.

      Volume: 13 Issue: 1 Pages: 1-14

    • DOI

      10.1186/s13041-020-00586-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stimulating muscarinic M<sub>1</sub> receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats2019

    • Author(s)
      Koga K, Matsuzaki Y, Migita K, Shimoyama S, Eto F, Nakagawa T, Matsumoto T, Terada K, Mishima K, Furue H, Honda K
    • Journal Title

      Brain Res

      Volume: 1704 Pages: 187

    • DOI

      10.1016/j.brainres.2018.10.013

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ethanol-induced enhancement of inhibitory synaptic transmission in the rat spinal substantia gelatinosa2018

    • Author(s)
      Yamada Akihiro、Koga Kohei、Kume Kazuhiko、Ohsawa Masahiro、Furue Hidemasa
    • Journal Title

      Molecular Pain

      Volume: 14 Pages: 1-13

    • DOI

      10.1177/1744806918817969

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice2018

    • Author(s)
      Qiu Shuang、Wu Yu、Lv Xinyou、Li Xia、Zhuo Min、Koga Kohei
    • Journal Title

      Molecular Brain

      Volume: 11(1):54 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s13041-018-0396-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model2018

    • Author(s)
      Migita K, Matsuzaki Y, Koga K, Matsumoto T, Mishima K, Hara S, Honda K
    • Journal Title

      J Pharmacological Sciences

      Volume: 137 Issue: 2 Pages: 233-236

    • DOI

      10.1016/j.jphs.2018.05.009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex2018

    • Author(s)
      Koga Kohei、Shimoyama Shuji、Yamada Akihiro、Furukawa Tomonori、Nikaido Yoshikazu、Furue Hidemasa、Nakamura Kazuhiko、Ueno Shinya
    • Journal Title

      Molecular Pain

      Volume: 14 Pages: 1-14

    • DOI

      10.1177/1744806918783478

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex2018

    • Author(s)
      Chen Tao、Taniguchi Wataru、Chen Qi-Yu、Tozaki-Saitoh Hidetoshi、Song Qian、Liu Ren-Hao、Koga Kohei、Matsuda Tsuyoshi、Kaito-Sugimura Yae、Wang Jian、Li Zhi-Hua、Lu Ya-Cheng、Inoue Kazuhide、Tsuda Makoto、Li Yun-Qing、Nakatsuka Terumasa、Zhuo Min
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1-17

    • DOI

      10.1038/s41467-018-04309-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex2017

    • Author(s)
      Koga Kohei、Yao Ikuko、Setou Mitsutoshi、Zhuo Min
    • Journal Title

      The Journal of Neuroscience

      Volume: 37 Issue: 14 Pages: 3887-3895

    • DOI

      10.1523/jneurosci.0023-16.2017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Chronic pain model alters GABAergic synaptic transmission in the mice anterior cingulate cortex.2019

    • Author(s)
      Koga K, Shimoyama S, Yamada A, Furue H, Nakamura K, Ueno S.
    • Organizer
      The 9th FAOPS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of ethanol on nociceptive synaptic transmission in the rat spinal dorsal horn.2019

    • Author(s)
      Yamada A, Koga K, Kume K, Ohsawa M, Imoto K, Furue H
    • Organizer
      The 9th FAOPS
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of in vivo field excitatory post synaptic potential (fEPSP) recording system at hippocampal CA3-CA3 synapses.2018

    • Author(s)
      Oishi N, Koga K, Nomoto M, Ohkawa N, Tsujimura S, Sano Y, Saitoh Y, Nishizono H, Matsuo M, Muramatsu S, Inokuchi K
    • Organizer
      第41回 日本神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Functional roles of presynaptic long-term potentiation in the anterior cingulate cortex for pain and anxiety.2018

    • Author(s)
      Koga K
    • Organizer
      第40回 日本疼痛学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 前帯状回のシナプス前終末における長期増強の形成と不安様行動2018

    • Author(s)
      古賀浩平
    • Organizer
      第27回 神経行動薬理若手研究者の集い
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] The ubiquitin proteasome system regulates presynaptic long-term potentiation in the anterior cingulate cortex2017

    • Author(s)
      Koga K, Yao I, Setou M, Furue H, Zhuo M
    • Organizer
      第95回 日本生理学会大会(高松)
    • Related Report
      2017 Research-status Report
  • [Presentation] SCRAPPER regulates spontaneous release and presynaptic long-term potentiation in the anterior cingulate cortex2017

    • Author(s)
      Koga K, Yao I, Setou M, Furue H, Zhuo M
    • Organizer
      第40回 日本神経科学会年会(千葉)
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi