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Optical validation of manipulative therapy via simultaneous measurement of cortical and muscular hemodynamic activities

Research Project

Project/Area Number 17K19932
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Health science and related fields
Research InstitutionNippon Sport Science University

Principal Investigator

MATSUDA Yasuhiro  日本体育大学, 保健医療学部, 助教 (20760200)

Co-Investigator(Kenkyū-buntansha) 小野 弓絵  明治大学, 理工学部, 専任教授 (10360207)
Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords手技療法 / 筋血流 / 光計測 / 生体医工学 / 脳活動 / 前頭前野
Outline of Final Research Achievements

The effectiveness of manipulative therapy in the medical field depends on the subjective evaluation of the therapist and the patient. However, there is no evidence-based objective evaluation method for manipulative therapy. This study used a combined optical measurement of cortical activity and peripheral muscle blood flow to simultaneously evaluate changes in the prefrontal activity and the blood flow of the muscle subjected to manipulative therapy. The measurement was carried out with healthy participants with simulated muscle pain under the straight leg raising test. The manual therapy reduced the subjective pain, which was associated with reduced prefrontal activity and increased blood flow of the target muscle. This result is a major step to develop a system that can objectively evaluate the physiological effects of manipulative therapy.

Academic Significance and Societal Importance of the Research Achievements

徒手的な治療法である手技療法の効果を脳活動や筋血流から評価するためのシステムを開発した.近赤外分光法を用いて疼痛誘発時の脳活動を計測し,手技療法による疼痛感の緩和に伴って脳活動が減少することを示した.また被験筋の筋血流変化を拡散相関分光法により計測することに成功し,手技療法の筋血流増加効果を示すことができた.これらの結果は術者と患者の主観的な評価に委ねられている手技療法の効果を客観的に評価できる可能性を示すものであり,臨床や教育現場での活用が期待される.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (29 results)

All 2020 2019 2018 2017

All Journal Article (12 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (17 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results)

  • [Journal Article] Optical evaluation of microvascular function at early and chronic stages of diabetes2020

    • Author(s)
      Sasaki S, Nakabayashi M, Ono Y, Ichinose M.
    • Journal Title

      Proc. SPIE 11237, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables

      Volume: 43863 Pages: 26-26

    • DOI

      10.1117/12.2545267

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time detection of fatigue effect on active muscle hemodynamics using diffuse correlation spectroscopy2020

    • Author(s)
      Nozaki K, Nakabayashi M, Ichinose M, Ono Y.
    • Journal Title

      Proc. SPIE 11237, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables

      Volume: 43863 Pages: 22-22

    • DOI

      10.1117/12.2542876

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature.2019

    • Author(s)
      Ichinose M, Nakabayashi M, Ono Y.
    • Journal Title

      Physiol Rep

      Volume: 7 Issue: 7 Pages: e14070-e14070

    • DOI

      10.14814/phy2.14070

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Possibility of Urinary Liver-Type Fatty Acid-Binding Protein as a Biomarker of Renal Hypoxia in Spontaneously Diabetic Torii Fatty Rats2019

    • Author(s)
      Tanabe Jun、Ogura Yuji、Nakabayashi Mikie、Nagai Yoshio、Watanabe Shiika、Sugaya Takeshi、Ohata Keiichi、Ichikawa Daisuke、Inoue Kazuho、Hoshino Seiko、Kimura Kenjiro、Shibagaki Yugo、Ono Yumie、Kamijo-Ikemori Atsuko
    • Journal Title

      Kidney and Blood Pressure Research

      Volume: 44 Issue: 6 Pages: 1476-1492

    • DOI

      10.1159/000503926

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 手技療法による骨格筋血流変化の定量評価. 拡散相関分光法による検討,2019

    • Author(s)
      松田康宏, 中林実輝絵,宮本彩華,小野弓絵
    • Journal Title

      日本体育大学紀要

      Volume: 48 Pages: 81-87

    • NAID

      120006599673

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sympathoexcitation constrains vasodilation in the human skeletal muscle microvasculature during post-occlusive reactive hyperemia.2018

    • Author(s)
      Ichinose M, Nakabayashi M, Ono Y.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: In press Issue: 2 Pages: H242-H253

    • DOI

      10.1152/ajpheart.00010.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 非侵襲生体信号の処理と解析 - V - NIRS 信号の処理と解析2018

    • Author(s)
      松田康宏, 小野弓絵
    • Journal Title

      システム制御情報学会

      Volume: 62 Pages: 435-440

    • NAID

      130007632592

    • Related Report
      2018 Research-status Report
  • [Journal Article] Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study2018

    • Author(s)
      Y. Ono, K. Esaki, Y. Takahashi, M. Nakabayashi, M. Ichinose, K. J. Lee
    • Journal Title

      Biomedical Optics Express

      Volume: 9(9) Issue: 9 Pages: 4539-4551

    • DOI

      10.1364/boe.9.004539

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of blood flow in human exercising muscle by diffuse correlation spectroscopy: a phantom model study.2018

    • Author(s)
      Mikie Nakabayashi, Yumie Ono, Masashi Ichinose
    • Journal Title

      Proc. SPIE 10486, Optical Tomography and Spectroscopy of Tissue XII

      Volume: 10486 Pages: 1048609-1048609

    • DOI

      10.1117/12.2288044

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳機能イメージング法からみた身体と情動のクロストーク2017

    • Author(s)
      松田康宏,小野弓絵
    • Journal Title

      神経内科

      Volume: 87 Pages: 84-89

    • Related Report
      2017 Research-status Report
  • [Journal Article] Detection of Blood Flow Speed in Shallow and Deep Tissues Using Diffuse Correlation Spectroscopy2017

    • Author(s)
      Mikie Nakabayashi, Yumie Ono
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 6 Issue: 0 Pages: 53-58

    • DOI

      10.14326/abe.6.53

    • NAID

      130006941703

    • ISSN
      2187-5219
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact2017

    • Author(s)
      Hirsch Joy、Zhang Xian、Noah J. Adam、Ono Yumie
    • Journal Title

      NeuroImage

      Volume: 157 Pages: 314-330

    • DOI

      10.1016/j.neuroimage.2017.06.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Optical evaluation of microvascular function at early and chronic stages of diabetes2020

    • Author(s)
      S Sasaki, M Nakabayashi, Y Ono, M Ichinose
    • Organizer
      SPIE Photonics West
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time detection of fatigue effect on active muscle hemodynamics using diffuse correlation spectroscopy2020

    • Author(s)
      K Nozaki, M Nakabayashi, M Ichinose, Y Ono
    • Organizer
      SPIE Photonics West
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integrated Effects of Sympathetic Vasoconstriction and Local Vasodilation in Human Skeletal Muscle and Skin Microvasculature2019

    • Author(s)
      M Ichinose, M Nakabayashi, Y Ono
    • Organizer
      American College of Sports Medicine (ACSM 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 拡散相関分光法による血流の可視化と医工学応用2019

    • Author(s)
      小野弓絵, 中林実輝絵
    • Organizer
      レーザー学会学術講演会 第39回年次大会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Invited
  • [Presentation] 拡散相関分光法を用いた 脳・生体組織血流の非侵襲計測と応用2019

    • Author(s)
      中林実輝絵, 小野弓絵
    • Organizer
      第58回 日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨格筋活動を考慮した組織血流速度評価法の開発2019

    • Author(s)
      佐々木 翔太郎、中林 実輝絵、野崎 寛一郎、一之瀬 真志、小野 弓絵
    • Organizer
      第58回 日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 拡散相関分光法を用いた筋疲労時の活動筋血流動態の計測2019

    • Author(s)
      野崎 寛一郎, 中林 実輝絵, 佐々木 翔太郎, 一之瀬 真志, 小野 弓絵
    • Organizer
      第58回 日本生体医工学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 拡散相関分光法による生体血流計測2019

    • Author(s)
      小野 弓絵,中林 実輝絵
    • Organizer
      "第26回医用近赤外線分光法研究会 第23回酸素ダイナミクス研究会 合同研究会 "
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 拡散相関分光法による組織血流イメージング2019

    • Author(s)
      小野弓絵
    • Organizer
      日本学術振興会・産学協力委員会・185委員会研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 拡散相関分光法を用いた手技療法前後の肩甲上部と大腿部後面の血流動態変化の計測2019

    • Author(s)
      松田康宏
    • Organizer
      第28回 日本柔道整復接骨医学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 身体機能の可視化技術と医療応用2018

    • Author(s)
      小野弓絵
    • Organizer
      第46回可視化情報シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Changes in skeletal muscle blood flow by manipulative therapy: a diffusion correlation spectroscopy study2018

    • Author(s)
      Yasuhiro Matsuda, Mikie Nakabayashi, Yumie Ono
    • Organizer
      fNIRS2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fatigue effect on muscle blood flow and oxygenation during handgrip exercise: a combined diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy study2018

    • Author(s)
      Mikie Nakabayashi,Kanichiro Nozaki, Yasuhiro Matsuda, Masashi Ichinose, Yumie Ono
    • Organizer
      fNIRS 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 拡散相関分光法を用いた 手技療法前後の血流動態変化の計測2018

    • Author(s)
      松田康宏
    • Organizer
      日本柔道整復接骨医学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Evaluation of blood flow in human exercising muscle by diffuse correlation spectroscopy: a phantom model study.2018

    • Author(s)
      Mikie Nakabayashi, Yumie Ono, Masashi Ichinose
    • Organizer
      Proc.SPIE 10486, Optical Tomography and Spectroscopy of Tissue XII
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 医療従事者に患者の「痛み」を伝える生体情報計測と可視化技術の検討2017

    • Author(s)
      松田康宏,鈴木達也,小野塚實,小野弓絵
    • Organizer
      人工知能学会全国大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 機能的近赤外分光法(fNIRS)を用いた疼痛可視化技術の検討2017

    • Author(s)
      松田康宏
    • Organizer
      日本柔道整復接骨医学会学術大会
    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2021-02-19  

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