• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of fluorescent probe for glucose uptake into skeletal muscle

Research Project

Project/Area Number 17K19933
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Health science and related fields
Research InstitutionWaseda University

Principal Investigator

AKIMOTO Takayuki  早稲田大学, スポーツ科学学術院, 教授 (00323460)

Co-Investigator(Kenkyū-buntansha) 加藤 義雄  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 (20415657)
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords血糖 / in vivoイメージング / 骨格筋 / 蛍光顕微鏡 / 糖代謝 / インスリン抵抗性 / 筋 / メカニカルストレス / 糖輸送体 / エネルギー代謝 / 筋収縮 / GLUT4 / 三次元培養
Outline of Final Research Achievements

Insulin resistance, which means the failure to take up blood glucose by insulin, is one of the fundamental mechanisms behind lifestyle-related diseases that are increasing worldwide, including obesity, metabolic syndrome, diabetes, and hyperlipidemia. At present, several drugs are the first treatments for insulin resistance in the clinic, but none of them have been able to improve the prognosis for all patients. Therefore, in this study, we developed a fluorescent probe that can observe the uptake of sugars into living cells and tissues. We are currently applying for the technology as a patent in Japan.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果によって細胞や組織への糖取り込みをモニタリングすることが可能となったため,血糖をコントロールする薬剤の開発等に応用することできると考えられる.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2018 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Korea University(韓国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effect of acute mid-intensity treadmill exercise on the androgen hormone level and uncoupling protein-1 expression in brown fat tissue of mouse.2018

    • Author(s)
      N. Kim, J. Kim, C. S. Yoo, K. Lim, T. Akimoto, J. H. Park.
    • Journal Title

      J Exerc Nutri Biochem

      Volume: 22(1) Pages: 15-22

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] 早稲田大学筋生物学研究室

    • URL

      https://www.waseda.jp/sem-muscle/index.html

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞の等取り込みを可視化するためのキメラタンパク質2018

    • Inventor(s)
      加藤義雄,古旗祐一,秋本崇之
    • Industrial Property Rights Holder
      加藤義雄,古旗祐一,秋本崇之
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-07-21   Modified: 2021-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi