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Innovative theranostics system with magnetic carbon nanotube

Research Project

Project/Area Number 17K20080
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering and related fields
Research InstitutionTohoku University

Principal Investigator

Saijo Yoshifumi  東北大学, 医工学研究科, 教授 (00292277)

Research Collaborator KODAMA Tetsuya  
KATO Toshiaki  
SIREGAR Syahril  
Project Period (FY) 2017-06-30 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywordsセラノスティクス / カーボンナノチューブ / 光音響イメージング / 温熱治療
Outline of Final Research Achievements

The basis of innovative theranostics system with magnetic carbon nanotube (M-CNT) was investigated. In the diagnostic side, M-CNT for photoacoustic (PA) imaging was developed and non-local means denoising was applied to reduce PA noise. In the therapeutic side, vibration of M-CNT caused by pulsed magnetic field was confirmed and M-CNT behavior during heating was simulated. The results indicate the application of M-CNT and PA imaging for innovative theranostics system.

Academic Significance and Societal Importance of the Research Achievements

ナノ粒子の製造技術の発展により、MRIや超音波用の造影剤を抗がん剤や遺伝子で修飾し、がん組織を診断すると同時に治療を行うセラノスティクス(therapy + diagnosticsの合成語)の研究が盛んにおこなわれている。本研究では、磁性カーボンナノチューブをセラノスティクスに応用するために、診断としては分解能30ミクロンの光音響イメージング、治療としては光が到達しない深部での温度上昇を可能にする高周波誘導加熱のそれぞれについて実証した。本研究成果により、磁性カーボンナノチューブによる革新的なセラノスティクス手法の基盤が開発された。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 Other

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results) Remarks (2 results)

  • [Journal Article] Basic study of improvement of axial resolution and suppression of time side lobe by phase-corrected Wiener filtering in photoacoustic tomography.2018

    • Author(s)
      Nagaoka Ryo, Yoshizawa Shin, Umemura ShinIchiro, Saijo Yoshifumi
    • Journal Title

      Jpn J Appl Phys.

      Volume: 57 Issue: 7S1 Pages: 07LD11-07LD11

    • DOI

      10.7567/jjap.57.07ld11

    • NAID

      210000149310

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A theoretical model of laser heating carbon nanotubes.2018

    • Author(s)
      Siregar Syahril, Oktamuliani Sri, Saijo Yoshifumi.
    • Journal Title

      Nanomaterials

      Volume: 8 Issue: 8 Pages: 580-580

    • DOI

      10.3390/nano8080580

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optical resolution photoacoustic microscopy with fast laser scanning and fixed photoacoustic detector.2018

    • Author(s)
      Ishikawa Kodai, Shintate Ryo, Nagaoka Ryo, Saijo Yoshifumi
    • Journal Title

      Conf Proc 39th IEEE Eng Med Biol Soc

      Volume: 1 Pages: 4800-4803

    • DOI

      10.1109/embc.2018.8513104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A method for the design of ultrasonic devices for scanning acoustic microscopy using impulsive signals2018

    • Author(s)
      Arakawa Mototaka、Kanai Hiroshi、Ishikawa Kazuo、Nagaoka Ryo、Kobayashi Kazuto、Saijo Yoshifumi
    • Journal Title

      Ultrasonics

      Volume: 84 Pages: 172-179

    • DOI

      10.1016/j.ultras.2017.10.023

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visualization of murine lymph vessels using photoacoustic imaging with contrast agents2018

    • Author(s)
      Nagaoka Ryo、Tabata Takuya、Yoshizawa Shin、Umemura Shin-ichiro、Saijo Yoshifumi
    • Journal Title

      Photoacoustics

      Volume: 9 Pages: 39-48

    • DOI

      10.1016/j.pacs.2018.01.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sparse-representation-based denoising of photoacoustic images2017

    • Author(s)
      Ul Haq Israr、Nagaoka Ryo、Siregar Syahril、Saijo Yoshifumi
    • Journal Title

      Biomed Phys Eng Express

      Volume: 3 Issue: 4 Pages: 045014-045014

    • DOI

      10.1088/2057-1976/aa7a44

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Photoacoustic and ultrasound microscope for imaging of three-dimensional skin vasculature.2018

    • Author(s)
      Saijo Yoshifumi, Nagaoka Ryo, Shintate Ryo, Iwazaki Hideaki, Omuro Toshiyuki, Ida Taiishiro, Yoshizawa Shin, Umernura
    • Organizer
      III International Caparica conference on ultrasonic-based applications: from analysis to synthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] High frame rate photoacoustic imaging of micro vessel.2018

    • Author(s)
      Saijo Yoshifumi, Ishikawa Kodai, Shintate Ryo, Nagaoka Ryo
    • Organizer
      2018 Progress in Electromagnetics Research Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of skin aging with photoacoustic and ultrasound microscopy2018

    • Author(s)
      Saijo Yoshifumi
    • Organizer
      ICME International Conference on Complex Medical Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Photoacoustic imaging of human skin with parabolic array transducer and tunable laser.2017

    • Author(s)
      Yoshifumi Saijo
    • Organizer
      IEEE Engineering in Medicine and Biology Society
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] High Frequency Ultrasound Imaging and its Recent Progress with Optics.2017

    • Author(s)
      Yoshifumi Saijo
    • Organizer
      The International Conference on Biomedical Ultrasound 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 西條研究室

    • URL

      http://www.ecei.tohoku.ac.jp/imaging/index.html

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Remarks] Saijo Laboratory

    • URL

      http://www.ecei.tohoku.ac.jp/imaging/index-e.html

    • Related Report
      2018 Annual Research Report 2017 Research-status Report

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Published: 2017-07-21   Modified: 2020-03-30  

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