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Determination of therapeutic factors using extracellular vesicles secreted from 3D-cultured stem cells

Research Project

Project/Area Number 17K20086
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering and related fields
Research InstitutionKyoto Prefectural University of Medicine (2020)
The University of Tokyo (2017-2019)

Principal Investigator

Uchida Satoshi  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20710726)

Project Period (FY) 2017-06-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords細胞外小胞 / 3次元培養 / 細胞移植治療 / 再生医療 / 核酸医薬 / スフェロイド / 間葉系幹細胞 / 炎症 / miRNA / 骨再生治療 / 再生医学 / ナノバイオ / 薬学
Outline of Final Research Achievements

In cell transplantation therapy, extracellular vesicles (EVs) secreted by the cells play significant therapeutic roles. This motivated us to study EVs for determining potent therapeutic factors. We focused on EVs secreted from MSCs in three-dimensional culture, which showed enhanced therapeutic effect compared to MSCs in conventional two-dimensional culture. Comprehensive comparison between EVs secreted from MSCs in two- and three-dimensional culture allowed us to determine various microRNAs possessing therapeutic functionalities, including anti-inflammatory and osteogenetic effects.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、細胞移植治療のメカニズム解明に繋がるだけでなく、細胞を使わない再生医療の実現に資する。細胞移植は優れた治療効果を示すものの、経済的コストや安全性に課題を残す。今回、移植細胞が分泌するEVに含まれる、高い治療効果を持つmiRNAを同定することに成功した。このmiRNAを治療薬として用いることで、細胞移植を行うことなく、同等の治療効果が得られる可能性がある。このことで、これまで重篤な疾患が主な対象であった再生医療を、より幅広い疾患へと応用できることが期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (54 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (27 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 27 results,  Open Access: 12 results) Presentation (24 results) (of which Int'l Joint Research: 8 results,  Invited: 9 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain2021

    • Author(s)
      S. Abbasi, S. Uchida, K. Toh, T.A. Tockary, A. Dirisala, K. Hayashi, S. Fukushima, K. Kataoka
    • Journal Title

      J. Control. Release

      Volume: 332 Pages: 260-268

    • DOI

      10.1016/j.jconrel.2021.02.026

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle2021

    • Author(s)
      Y. Fukushima, S. Uchida, H. Imai, H. Nakatomi, K. Kataoka, N. Saito, K. Itaka
    • Journal Title

      Biomaterials

      Volume: 270 Pages: 120681-120681

    • DOI

      10.1016/j.biomaterials.2021.120681

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency2021

    • Author(s)
      Yoshinaga Naoto、Uchida Satoshi、Dirisala Anjaneyulu、Naito Mitsuru、Osada Kensuke、Cabral Horacio、Kataoka Kazunori
    • Journal Title

      Journal of Controlled Release

      Volume: 330 Pages: 317-328

    • DOI

      10.1016/j.jconrel.2020.12.033

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines2020

    • Author(s)
      Dirisala Anjaneyulu、Uchida Satoshi、Toh Kazuko、Li Junjie、Osawa Shigehito、Tockary Theofilus A.、Liu Xueying、Abbasi Saed、Hayashi Kotaro、Mochida Yuki、Fukushima Shigeto、Kinoh Hiroaki、Osada Kensuke、Kataoka Kazunori
    • Journal Title

      Science Advances

      Volume: 6 Issue: 26

    • DOI

      10.1126/sciadv.abb8133

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo2020

    • Author(s)
      Koji Kyoko、Yoshinaga Naoto、Mochida Yuki、Hong Taehun、Miyazaki Takuya、Kataoka Kazunori、Osada Kensuke、Cabral Horacio、Uchida Satoshi
    • Journal Title

      Biomaterials

      Volume: 261 Pages: 120332-120332

    • DOI

      10.1016/j.biomaterials.2020.120332

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Guanidine-phosphate interactions stabilize polyion complex micelles based on flexible catiomers to improve mRNA delivery2020

    • Author(s)
      T. Miyazaki, S. Uchida, H. Hatano, Y. Miyahara, A. Matsumoto, H. Cabral
    • Journal Title

      Eur. Polym. J.

      Volume: 140 Pages: 110028-110028

    • DOI

      10.1016/j.eurpolymj.2020.110028

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Polymeric Nanocarriers with Controlled Chain Flexibility Boost mRNA Delivery In Vivo through Enhanced Structural Fastening2020

    • Author(s)
      Miyazaki Takuya、Uchida Satoshi、Nagatoishi Satoru、Koji Kyoko、Hong Taehun、Fukushima Shigeto、Tsumoto Kouhei、Ishihara Kazuhiko、Kataoka Kazunori、Cabral Horacio
    • Journal Title

      Advanced Healthcare Materials

      Volume: 9 Issue: 16 Pages: 2000538-2000538

    • DOI

      10.1002/adhm.202000538

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nanomedicine-Based Approaches for mRNA Delivery2020

    • Author(s)
      S. Uchida, F. Perche, C. Pichon, H. Cabral
    • Journal Title

      Mol. Pharm._

      Volume: 17 Issue: 10 Pages: 3654-3684

    • DOI

      10.1021/acs.molpharmaceut.0c00618

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy2020

    • Author(s)
      S. Uchida, K. Yanagihara, A. Matsui, K. Kataoka, K. Itaka
    • Journal Title

      Micromachines

      Volume: 11 Issue: 4 Pages: 426-426

    • DOI

      10.3390/mi11040426

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application2020

    • Author(s)
      Ueki Ryosuke、Uchida Satoshi、Kanda Naoto、Yamada Naoki、Ueki Ayaka、Akiyama Momoko、Toh Kazuko、Cabral Horacio、Sando Shinsuke
    • Journal Title

      Science Advances

      Volume: 6 Issue: 14

    • DOI

      10.1126/sciadv.aay2801

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 50-nm-Sized Micellar Assembly of Thermoresponsive Polymer-Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration.2020

    • Author(s)
      B. S. Kim, S. Osawa, M. Naito, S. Ogura, R. Kamegawa, H. Ishida, H. J. Kim, S. Uchida, K. Miyata
    • Journal Title

      Advanced Therapeutics

      Volume: 3 Issue: 2 Pages: 1900123-1900123

    • DOI

      10.1002/adtp.201900123

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Single-stranded DNA-packaged polyplex micelle as adeno-associated-virus-inspired compact vector to systemically target stroma-rich pancreatic cancer.2019

    • Author(s)
      T. A. Tockary, W. Foo, A. Dirisala, Q. Chen, S. Uchida, S. Osawa, Y. Mochida, X. Liu, H. Kinoh, H. Cabral, K. Osada, K. Kataoka
    • Journal Title

      ACS Nano

      Volume: 13 Issue: 11 Pages: 12732-12742

    • DOI

      10.1021/acsnano.9b04676

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhancement of motor function 1 recovery after spinal cord injury in mice by delivery of brain derived neurotrophic factor mRNA.2019

    • Author(s)
      S. T. Crowley, Y. Fukushima, S. Uchida, K. Kataoka, K. Itaka
    • Journal Title

      Mol. Ther. Nucleic Acids

      Volume: 17 Pages: 465-476

    • DOI

      10.1016/j.omtn.2019.06.016

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bundling mRNA strands to prepare nano-assemblies with enhanced stability towards RNase for in vivo delivery.2019

    • Author(s)
      N. Yoshinaga, E. Cho, K. Koji, Y. Mochida, M. Naito, K. Osada, K. Kataoka, H. Cabral, S. Uchida
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 58 Issue: 33 Pages: 11360-11363

    • DOI

      10.1002/anie.201905203

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers2019

    • Author(s)
      Watanabe Sumiyo、Hayashi Kotaro、Toh Kazuko、Kim Hyun Jin、Liu Xueying、Chaya Hiroyuki、Fukushima Shigeto、Katsushima Keisuke、Kondo Yutaka、Uchida Satoshi、Ogura Satomi、Nomoto Takahiro、et al.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1894-1894

    • DOI

      10.1038/s41467-019-09856-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration2019

    • Author(s)
      Kurimoto Shota、Yoshinaga Naoto、Igarashi Kazunori、Matsumoto Yu、Cabral Horacio、Uchida Satoshi
    • Journal Title

      Molecules

      Volume: 24 Issue: 7 Pages: 1303-1303

    • DOI

      10.3390/molecules24071303

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Treatment of intervertebral disk disease by administration of messenger RNA encoding a cartilage-anabolic transcription factor.2019

    • Author(s)
      C. -Y. Lin, S. T. Crowley, S. Uchida, Y. Komaki, K. Kataoka, K. Itaka
    • Journal Title

      Mol. Ther. Nucleic Acids

      Volume: 16 Pages: 162-171

    • DOI

      10.1016/j.omtn.2019.02.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA.2019

    • Author(s)
      S. Uchida, K. Kataoka
    • Journal Title

      J. Biomed. Mater. Res. A

      Volume: 107 Issue: 5 Pages: 978-990

    • DOI

      10.1002/jbm.a.36614

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Precise tuning of disulfide crosslinking in mRNA polyplex micelles for optimizing extracellular and intracellular nuclease tolerability.2019

    • Author(s)
      A. Dirisala, S. Uchida, T. A. Tockary, N. Yoshinaga, J. Li, S. Osawa, L. Gorantla, S. Fukushima, K. Osada, K. Kataoka
    • Journal Title

      J. Drug Target.

      Volume: 印刷中 Issue: 5-6 Pages: 670-680

    • DOI

      10.1080/1061186x.2018.1550646

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tunable non-enzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency.2019

    • Author(s)
      M. Naito, Y. Otsu, R. Kamegawa, K. Hayashi, S. Uchida, H. -J. Kim, K. Miyata
    • Journal Title

      Sci. Technol. Adv. Mater.

      Volume: 20 Issue: 1 Pages: 105-115

    • DOI

      10.1080/14686996.2019.1569818

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection.2019

    • Author(s)
      N. Yoshinaga, S. Uchida, M. Naito, K. Osada, H. Cabral, K. Kataoka
    • Journal Title

      Biomaterials

      Volume: 197 Pages: 255-267

    • DOI

      10.1016/j.biomaterials.2019.01.023

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection.2018

    • Author(s)
      A. Matsui, S. Uchida, A. Hayashi, K. Kataoka, K. Itaka
    • Journal Title

      J. Control. Release

      Volume: 285 Pages: 1-11

    • DOI

      10.1016/j.jconrel.2018.06.033

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids2018

    • Author(s)
      Yanagihara K, Uchida S, Ohba S, Kataoka K, Itaka K
    • Journal Title

      Molecular Therapy - Methods & Clinical Development

      Volume: 9 Pages: 358-366

    • DOI

      10.1016/j.omtm.2018.04.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination2018

    • Author(s)
      Uchida Satoshi、Yoshinaga Naoto、Yanagihara Kayoko、Yuba Eiji、Kataoka Kazunori、Itaka Keiji
    • Journal Title

      Biomaterials

      Volume: 150 Pages: 162-170

    • DOI

      10.1016/j.biomaterials.2017.09.033

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polyplex Micelles with Phenylboronate/Gluconamide Cross-Linking in the Core Exerting Promoted Gene Transfection through Spatiotemporal Responsivity to Intracellular pH and ATP Concentration2017

    • Author(s)
      Yoshinaga Naoto、Ishii Takehiko、Naito Mitsuru、Endo Taisuke、Uchida Satoshi、Cabral Horacio、Osada Kensuke、Kataoka Kazunori
    • Journal Title

      Journal of the American Chemical Society

      Volume: 139 Issue: 51 Pages: 18567-18575

    • DOI

      10.1021/jacs.7b08816

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain2017

    • Author(s)
      Anraku Y.、Kuwahara H.、Fukusato Y.、Mizoguchi A.、Ishii T.、Nitta K.、Matsumoto Y.、Toh K.、Miyata K.、Uchida S.、Nishina K.、Osada K.、Itaka K.、Nishiyama N.、Mizusawa H.、Yamasoba T.、Yokota T.、Kataoka K.
    • Journal Title

      Nat Commun

      Volume: 8 Issue: 1 Pages: 2001-2009

    • DOI

      10.1038/s41467-017-00952-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia2017

    • Author(s)
      Lee Dian-Jang、Kessel Eva、Lehto Taavi、Liu Xueying、Yoshinaga Naoto、Padari K?rt、Chen Ying-Chen、Kempter Susanne、Uchida Satoshi、R?dler Joachim O.、Pooga Margus、Sheu Ming-Thau、Kataoka Kazunori、Wagner Ernst
    • Journal Title

      Bioconjugate chemistry

      Volume: 28 Issue: 9 Pages: 2393-2409

    • DOI

      10.1021/acs.bioconjchem.7b00383

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] メッセンジャーRNAのCOVID-19ワクチンへの応用とその後の展望2021

    • Author(s)
      内田 智士
    • Organizer
      2020年度 医療産業イノベーションフォーラム,
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 新型コロナウイルスや未来のパンデミックに対するmRNAナノワクチンの開発2020

    • Author(s)
      内田 智士
    • Organizer
      第7回COINSシンポジウム ~小さく寄り添い大きく守る、未来の医療はすぐそこに~
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] RNAオリゴマーを用いたmRNA修飾法の開発とmRNA送達、ワクチンへの展開2020

    • Author(s)
      内田 智士
    • Organizer
      核酸医薬シンポジウム2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] mRNA bundling inside polyion complexes for their physical and biological stabilization2020

    • Author(s)
      S. Uchida, K. Koji, N. Yoshinaga, Y. Mochida, T. Hong, H. Cabral
    • Organizer
      8th International mRNA Health Conference
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] mRNA nanomachine for treating rare genetic disorders2020

    • Author(s)
      S. Uchida
    • Organizer
      India-Japan Webinar on "Rare Genetic Disorders"
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RNA構造に着目したメッセンジャーRNA 医薬の機能化2020

    • Author(s)
      内田 智士
    • Organizer
      第69回 高分子討論会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] DNA、mRNAのex vivo導入による細胞治療の効果向上2020

    • Author(s)
      内田 智士
    • Organizer
      第36回日本DDS学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Preparation of nanoassemblies from several mRNA strands for enhancing nuclease stability.2020

    • Author(s)
      S. Uchida, N. Yoshinaga, E. Cho, K. Koji, K. Kataoka, H. Cabral
    • Organizer
      International Symposium on Biomedical Materials for Drug/Gene Delivery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of mRNA polyplex micelles through engineering polymers and mRNA for in vivo therapeutic applications2020

    • Author(s)
      S. Uchida
    • Organizer
      IBS CNM Seminar
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Stabilization of mRNA polyplex micelles for in vivo delivery by engineering mRNA2019

    • Author(s)
      S. Uchida, N. Yoshinaga, H. Cabral, K. Kataoka
    • Organizer
      2nd G’L’owing Polymer Symposium in KANTO
    • Related Report
      2019 Research-status Report
  • [Presentation] 複複数のmRNA鎖を束ねることで生体内酵素分解を抑制させたmRNAナノ集合体の開発2019

    • Author(s)
      内田 智士、吉永 直人、趙 オル、小路 恭子、長田 健介、片岡 一則、Horacio Cabral
    • Organizer
      第41回バイオマテリアル学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Nanoengineering mRNA through short RNA hybridization for biomedical application2019

    • Author(s)
      S. Uchida
    • Organizer
      1st Thailand-Australia-Japan Joint Research Meeting on Nanomedicine
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 複数のmRNA鎖を束ねたナノ集合体の開発と生体内投与2019

    • Author(s)
      内田 智士、吉永 直人、趙 オル、小路 恭子、長田 健介、片岡 一則、Horacio Cabral
    • Organizer
      日本核酸医薬学会第5回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 複数のmRNA鎖からなるナノ集合体を用いたmRNA安定化とその生体内投与2019

    • Author(s)
      内田 智士、吉永 直人、趙 オル、小路 恭子、長田 健介、片岡 一則、Horacio Cabral
    • Organizer
      第35回日本DDS学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Hybridization of mRNA with a small number of short cholesteryl RNA oligonucleotides for tight mRNA packaging to polyplex micelles.2019

    • Author(s)
      S. Uchida, N. Yoshinaga, H. Cabral, K. Kataoka
    • Organizer
      19th Smposium for gene design and delivery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 標題 コレステロール修飾相補鎖RNAを用いたmRNA搭載高分子ミセル安定化2018

    • Author(s)
      内田 智士、吉永 直人、長田 健介、位髙 啓史、Horacio Cabral、片岡 一則
    • Organizer
      第40回日本バイオマテリアル学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 免疫賦活化アジュバント機能一体型 2本鎖mRNAワクチン2018

    • Author(s)
      内田 智士、位髙 啓史、片岡 一則
    • Organizer
      日本核酸医薬学会第4回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高分子ミセルを用いた メッセンジャー(m)RNA医薬の送達と 疾患治療への展開2018

    • Author(s)
      内田 智士
    • Organizer
      第34回日本DDS学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Therapeutic application of mRNA delivery using polyplex micelles2018

    • Author(s)
      Satoshi Uchida, Keiji Itaka, Kazunori Kataoka
    • Organizer
      Finland-Japan Workshop: The next generation medical engineering in biomaterials
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Incorporation of Immunostimulatory Property to Messenger RNA Molecule by Hybridizing RNA to Poly A Sequence for Effective Vaccination2018

    • Author(s)
      Satoshi Uchida, Keiji Itaka, Kazunori Kataoka
    • Organizer
      21st annual meeting ASGCT
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高分子ミセルを用いたメッセンジャーRNAデリバリー2017

    • Author(s)
      内田智士
    • Organizer
      理研シンポジウム:理研/iCONM/物材研 医工学ネットワーク
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 免疫賦活化能を向上させた2本鎖メッセンジャーRNAワクチンの開発2017

    • Author(s)
      内田 智士、吉永 直人、柳原 歌代子、弓場 獎司、位髙 啓史、片岡 一則
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] mRNA搭載ナノミセルを用いた抗アミロイドβ単鎖抗体導入によるアルツハイマー病治療2017

    • Author(s)
      内田 智士、F. Perche、秋葉 宏樹、位髙 啓史、津本 浩平、片岡 一則
    • Organizer
      日本核酸医薬学会第3回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 抗アミロイドβ単鎖抗体発現mRNA搭載ナノミセルを用いたアルツハイマー病治療2017

    • Author(s)
      内田 智士、F. Perche、秋葉 宏樹、位髙 啓史、津本 浩平、片岡 一則
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Research-status Report
  • [Remarks] ホームページ

    • URL

      http://www.f.kpu-m.ac.jp/y/medchem/uchida.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.bmc.t.u-tokyo.ac.jp/suchida.html

    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] ゲノム編集用ミセル2020

    • Inventor(s)
      片岡 一則,内田 智士,アッバシ サエド
    • Industrial Property Rights Holder
      片岡 一則,内田 智士,アッバシ サエド
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-113434
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2017-07-21   Modified: 2022-01-27  

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