• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Spatiotemporal control of physical stimuli in spontaneously formed intracellular mechanical fields

Research Project

Project/Area Number 17K20093
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Furukawa Katsuko  東京大学, 大学院工学系研究科(工学部), 准教授 (90343144)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords物理刺激 / 細胞分化 / 再生医療 / メカノバイオエンジニアリング / 内部応力 / 外部刺激 / 3次元造形 / 物理刺激負荷デバイス / メカニカルストレス
Outline of Final Research Achievements

Living tissue is constantly exposed to mechanical stress, which is a physical stimulus. Conventional mechanical stress research has focused solely on the effects of mechanical stress on cells. On the other hand, in this study, it was shown that the cells in the body spontaneously change the mechanical field in the cell depending on the local environment, which may be connected to a high-level biological phenomenon.

Academic Significance and Societal Importance of the Research Achievements

そこで本研究では,細胞内にあらかじめ自発的な力学場(応力)を形成して,外部から連続したメカニカルストレスを負荷することによる細胞応答を調べることを目的とした研究を行った.最終的に自発的に形成された力学場のメカニカルストレスによる時空間応答に及ぼす効果を,生理的な観点から解析し,力学刺激に関する学術の根本を理解するための学術的な基盤の構築を目指した研究を推進した.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (73 results)

All 2020 2019 2018 2017

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (53 results) (of which Int'l Joint Research: 11 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Local Strain Distribution and Increased Intracellular Ca2+ Signaling in Bovine Articular Cartilage Exposed to Compressive Strain.2020

    • Author(s)
      Wenjing Huang, Minami Nagasaka, Katsuko S. Furukawa , Takashi Ushida
    • Journal Title

      Journal of Biomechanical Engineering

      Volume: 142(6) Issue: 6

    • DOI

      10.1115/1.4045807

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New microvascular anastomotic device for end-to-side anastomosis using negative pressure; a preliminary study2020

    • Author(s)
      Tachi Kazufumi、Furukawa Katsuko S.、Koshima Isao、Ushida Takashi
    • Journal Title

      Journal of Plastic Surgery and Hand Surgery

      Volume: Published online Issue: 3 Pages: 1-5

    • DOI

      10.1080/2000656x.2020.1729776

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 機械的刺激負荷により惹起された細胞内PLC-IP3シグナル応答のFRETを用いたリアルタイムイメージング2020

    • Author(s)
      張 珉箕, 林恵範, 古川 克子,牛田多加志
    • Journal Title

      日本臨床バイオメカニクス学会誌

      Volume: In press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local Strain DistributionandIncreased Intracellular Ca2+ Signalingin BovineArticular 1 Cartilage Exposed to Compressive Strain2020

    • Author(s)
      Wenjing Huang, Minami Nagasaka, Katsuko S Furukawa, Takashi Ushida
    • Journal Title

      Journal of Biomechanical Engineering

      Volume: 142(6) Pages: 061008-061008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteogenic differentiation of murine mesenchymal stem cells by combination of surface topography and uniaxial stress2020

    • Author(s)
      Heonuk Jeong, Xiaoguang Yang, Zihan Pei, Takashi Ushida and Katsuko S Furukawa
    • Journal Title

      Journal of Biomechanical Science Engineering

      Volume: In press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressed osteogenic differentiation of murine mesenchymal stem cell by narrow microgrooves2020

    • Author(s)
      Heonuk Jeong, Xiaoguang Yang, Ushida Takashi, Katsuko S Furukawa
    • Journal Title

      Japanese Journal of Clinical Biomechanics

      Volume: In press

    • NAID

      40022375385

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mismatch between local chondrocyte death and mechanical properties of porcine articular cartilage exposed to injurious compression2020

    • Author(s)
      Wenjing Huang, Hikaru Sasaki, Katsuko S Furukawa, and Takashi Ushida
    • Journal Title

      Japanese Journal of Clinical Biomechanics

      Volume: In press

    • NAID

      40022375428

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired contractile ability in human endometrial stromal cells by passive loading of cyclic tensile stretch2020

    • Author(s)
      Jeonghyun Kim, Takashi Ushida, Kevin Montagne, Yasushi Hirota, Osamu Yoshino, Takehiro Hiraoka, Yutaka Osuga, and Katsuko S Furuakwa
    • Journal Title

      Scientific Reports

      Volume: In press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of internal perfusion bioreactor to promote decellularization for rat uterine tissue2020

    • Author(s)
      Narintadeach Charoensombut, Kinyoshi Kawabata, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko S Furukawa
    • Journal Title

      Japanese Journal of Clinical Biomechanics

      Volume: -

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Extracellular matrix derived hydrogel from decellularised uterine tissue: A synthesis and analysis2019

    • Author(s)
      Vutipongsatorn Kritchai、Kim Jeonghyun、Kinyoshi Kawabata、Charoensombut Narintadeach、Shu Takeda、Ushida Takashi、Furukawa Katsuko
    • Journal Title

      Clinical Medicine

      Volume: 19 Issue: 2 Pages: 102-102

    • DOI

      10.7861/clinmedicine.19-2-s102

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication and characterization of extracellular matrix hydrogel derived from uterine decellularized tissues2019

    • Author(s)
      KAWABATA Kinyoshi、KIM Jeonghyun、CHAROENSOMBUT Narintadeach、KIMURA Tsuyoshi、KISHIDA Akio、USHIDA Takashi、FURUKAWA Katsuko S
    • Journal Title

      The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME

      Volume: 2019.31 Issue: 0 Pages: 2C24

    • DOI

      10.1299/jsmebio.2019.31.2C24

    • NAID

      130007667828

    • ISSN
      2424-2829
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of uterine decellularized matrix using high hydrostatic pressure through depolymerization of actin filaments2019

    • Author(s)
      KIM Jeonghyun、TAKEDA Shu、CHAROENSOMBUT Narintadeach、KAWABATA Kinyoshi、KISHIMOTO Yugo、KIMURA Tsuyoshi、KISHIDA Akio、USHIDA Takashi、FURUKAWA, Katsuko S
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 14 Issue: 3 Pages: 19-19

    • DOI

      10.1299/jbse.19-00097

    • NAID

      130007741730

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydrostatic pressurization of dissociated ATDC5 aggregates as an in vitro model of mechanical load-induced chondrocyte damage2019

    • Author(s)
      Kevin Montagne, Katsuko S. Furukawa, Takashi Ushida
    • Journal Title

      AATEX Journal

      Volume: 24(2) Pages: 75-82

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the Inner Surface Microstructure of Decellularized cortical bone by a scanning electron microscope2019

    • Author(s)
      Honuk Jeong, Jun Asai, Takashi Ushida, Katsuko S Furukawa
    • Journal Title

      Bioengineering (Basel)

      Volume: 6(3) Issue: 3 Pages: 86-93

    • DOI

      10.3390/bioengineering6030086

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular traction forces increase during consecutive mechanical stretching following traction force attenuation2017

    • Author(s)
      TSUKAMOTO Akira、RYAN Katie R.、MITSUOKA Yusuke、FURUKAWA Katsuko S.、USHIDA Takashi
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 12 Issue: 3 Pages: 17-00118-17-00118

    • DOI

      10.1299/jbse.17-00118

    • NAID

      130005830376

    • ISSN
      1880-9863
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Angiogenesis Platform using a Cubic Artificial Eggshell with Patterned Blood Vessels on Chicken Chorioallantoic Membrane2017

    • Author(s)
      W. Huang, M. Itayama, F. Arai, K.S. Furukawa, T. Ushida, and T. Kawahara
    • Journal Title

      PLoS ONE

      Volume: 12(4) Issue: 4 Pages: 1-20

    • DOI

      10.1371/journal.pone.0175595

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High hydrostatic pressure induces pro-osteoarthritic changes in cartilage precursor cells: a transcriptome analysis2017

    • Author(s)
      Montagne Kevin, Onuma Yasuko, Ito Yuzuru, Aiki Yasuhiko, Furukawa Katsuko and Ushida Takashi
    • Journal Title

      PLOS One

      Volume: 12 Issue: 8 Pages: e0183226-e0183226

    • DOI

      10.1371/journal.pone.0183226

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypergravity down-regulates c-fos gene expression via ROCK/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells2017

    • Author(s)
      Kim Jeonghyun, Montagne Kevin, Nemoto Hidetoshi, Ushida Takashi and Furukawa Katsuko
    • Journal Title

      PLOS One

      Volume: 12 Issue: 9 Pages: e0185394-e0185394

    • DOI

      10.1371/journal.pone.0185394

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 超高静水圧を用いた子宮脱細胞化組織作製手法の評価2020

    • Author(s)
      河鰭 公祥, チャロエンソムバット ナリンタデチ, 王 東哲, 金田 昴, 金 定賢, 木村 剛, 岸田 晶夫, 牛田 多加志, 古川 克子
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Fabrication of decellularized uterine scaffold by enzymatic-high hydrostatic pressure2020

    • Author(s)
      Charoensombut Narintadeach, 金定賢, 河鰭公祥, 木村剛, 岸田晶夫, 牛田多加志, 古川克子
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Osteoclast Differentiation of Murine Precursor Cells on Microgroove Patterned Substrate2019

    • Author(s)
      Heonuk Jeong, Dain Kim, Takashi Ushida, Katsuko S. Furukawa
    • Organizer
      TERMIS-EU 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of Osteogenic Differentiation Timing by Substrate Microtopography2019

    • Author(s)
      Heonuk Jeong, Xiaoguang Yang, 牛田多加志, 古川克子
    • Organizer
      日本機械学会2019年度年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 軟骨前駆細胞における過大静水圧力による変形性関節症関連遺伝子の変動の検討2019

    • Author(s)
      モンターニュ ケヴィン, 小沼 泰子,伊藤 弓弦, 相木 泰彦, 古川克子,牛田 多加志
    • Organizer
      日本機械学会2019年度年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超高静水圧を用いた子宮脱細胞化組織の作製2019

    • Author(s)
      河鰭公祥, チャロエンソムバットナリンタデチ, 岸本侑吾, 金定賢, 王東哲, 金田昴, 木村剛, 岸田晶夫, 牛田多加志, 古川克子
    • Organizer
      第46回日本臨床バイオメカニクス学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of enzymatic-high hydrostatic pressure method to decellularized uterine tissue for uterus regeneration in murine model2019

    • Author(s)
      Narintadeach CHAROENSOMBUT, Kim Jeong Hyun, 河鰭公祥, 木村剛, 岸田晶夫, 牛田多加志, 古川克子
    • Organizer
      第46回日本臨床バイオメカニクス学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞微小変形に対する細胞内シグナル応答のリアルタイムイメージング2019

    • Author(s)
      Chang Minki, Montagne Kevin, 古川克子, 牛田多加志
    • Organizer
      第46回日本臨床バイオメカニクス学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Control of Cell Adhesion and Osteogenic Differentiation by Substrate Microtopography and Uniaxial Tensile Strains2019

    • Author(s)
      ジョン ホヌク, ヤン シャオガン, Pei Zihan, 牛田多加志,古川克子
    • Organizer
      第46回日本臨床バイオメカニクス学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] High hydrostatic pressure mimics pro-osteoarthritic changes in chondrocyte precursor cells2019

    • Author(s)
      kevin Montagne, Yasuo Onuma, Yuzuru Ito, Aiki Yasuhiro, Katsuko Furukawa, Takashi Ushida
    • Organizer
      日本動物実験代替法学会 第32回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Osteoclast Differentation of Murine Prcursor Cells on Microgroove Patterned Substrate2019

    • Author(s)
      Heonuk Jeong, Dain Kim, Takashi Ushida, Katsuko Furukawa
    • Organizer
      AP Biomech2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高静水圧負荷による子宮組織再生のための脱細胞化担体の製作2019

    • Author(s)
      岸本 侑悟, Kim Jeonghyun,河鰭公祥, Charoensombut Narintadeach, 武田 周, 薮崎 名保恵, 古川 克子, 牛田多加志, 木村 剛, 岸田晶夫
    • Organizer
      日本機械学会 関東学生会第58回学生員卒業研究発表講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] エレクトロスピニング技術による小口径再生血管担体の機械的性質のコントロール2018

    • Author(s)
      本多理, メサーネンテーム, 増本憲泰, 牛田多加志, 古川克子
    • Organizer
      第57回日本生体医工学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] DNA breaks in chondrocyte progenitor cells under cyclic hydrostatic pressure2018

    • Author(s)
      Koichiro Maki, Katsuko Furukawa, Takashi Ushida
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Novel application of three-dimensional tissue engineered constructs fabricated by human endometrial stromal cells to facilitate early embryo growth and implantation2018

    • Author(s)
      Jeonghyun Kim, Takayuki Harada, Yasushi Hirota, Takehiro Hiraoka, Osamu Yoshino, Shigeru Saito, Yutaka Osuga, Takashi Ushida, Katsuko Furukawa
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] High hydrostatic pressure induces Fos expression in chondrocyte precursor cells via a Src/PKC/ERK/Elk1-dependent pathway2018

    • Author(s)
      Kevin Montagne, Katsuko Furukawa, Takashi Ushida
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pro-osteoarthritic gene expression changes in chondrocyte precursor cells evoked by high hydrostatic pressure2018

    • Author(s)
      Kevin Montagne, Yasuko Onuma, Yuzuru Ito, Yasuhiko Aiki, Katsuko Furukawa, Takashi Ushida
    • Organizer
      8th World Congress of Biomechanics
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of new in vitro model that mimics early implantation of embryo using tissue engineered constructs derived from human endometrial stromal cells2018

    • Author(s)
      Jeonghyun Kim,Takayuki Harada,Yasushi Hirota,Takehiro Hiraoka,
    • Organizer
      5th TERMIS World Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] エレクトロスピニング技術を用いた再生血管担体の力学的性質コントロール2018

    • Author(s)
      本多 理,増本 憲泰,牛田 多加志,古川 克子
    • Organizer
      日本機械学会2018年度年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] In vitro 組織培養モデルを用いた関節軟骨の成熟過程に対する周期的静水圧の影響2018

    • Author(s)
      Chang Minki,牛田 多加志,古川 克子
    • Organizer
      日本機械学会2018年度年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 第4 級アンモニウムキトサンおよびアルデヒド官能化ヒアルロン酸ハイドロゲルによるMC3T3-E1 細胞の骨分化の促進2018

    • Author(s)
      王 強,古川 克子
    • Organizer
      日本機械学会2018年度年次大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Estimation of Bound Water Ratio in Extracellular Matrices using Terahertz Time-Domain Spectroscopy2018

    • Author(s)
      Tetsuri Kuwazuru, Atsushi Tsujimoto, Ayaka Kamada, Katsuko Furukawa, Seiji Nishizawa, Takashi Ushida
    • Organizer
      29th 2018 International Symposium on Micro-NanoMechatronics and Human Science
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 子宮脱細胞化マトリクスハイドロゲルの作製と評価2018

    • Author(s)
      河鰭公祥, Jeonghyun Kim, Narintadeach Charoensombut, 木村剛, 岸田晶夫, 牛田多加志, 古川克子
    • Organizer
      日本機械学会第31回バイオエンジニアリング講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 破骨細胞の分化過程における線状の微細表面構造の効果2018

    • Author(s)
      Jeong Heonuk,Kim Dain,牛田 多加志,古川 克子
    • Organizer
      日本機械学会第31回バイオエンジニアリング講演会
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] In vitro facilitation of early embryo implantation using three-dimensional tissue-engineered constructs fabricated by human endometrial stromal cells2018

    • Author(s)
      Jeonghyun Kim, Yasushi Hirota, Takehiro Hiraoka, Osamu Yoshino, Shigeru Saito, Yutaka Osuga, Takashi Ushida, and Katsuko Furukawa
    • Organizer
      The 31th Bioengineering conference of the Japan Society of Mechanical Engineering
    • Related Report
      2018 Research-status Report
  • [Presentation] 軟骨前駆細胞における過大静水圧刺激による初期応答遺伝子Fosの変動の検討2018

    • Author(s)
      Montagne Kevin, 小林 秀行, 古川 克子, 牛田 多加志
    • Organizer
      日本機械学会第31回バイオエンジニアリング講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラット子宮再生のための高静水圧を用いた新たな脱細胞担体製作法の開発2018

    • Author(s)
      Narintadeach Charoensombut, Jeonghyun Kim, Kinyoshi Kawabata, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida and Katsuko Furukawa
    • Organizer
      日本機械学会第31回バイオエンジニアリング講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Functionality of Regenerated Uterine Tissue Created with iBTA Biosheet Implantation in SD-Rats.2018

    • Author(s)
      Teemu Mehtonen, 牛田 多加志, 古川 克子
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Endometrial stromal cells in tissue engineered constructs to facilitate early implantation of embryo.2018

    • Author(s)
      Jeonghyun Kim, 牛田 多加志, 古川 克子
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] テラヘルツ時間領域分光法によるゼラチンゲルの水和特性評価2018

    • Author(s)
      桑鶴 哲理, 辻本敦司, 鎌田彩花, 黎豊, 西澤誠治, 古川克子, 牛田多加志
    • Organizer
      日本機械学会関東支部第24期総会・講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 大腿骨膝関節の成熟過程に対する周期的静水圧の影響2018

    • Author(s)
      Chang Minki, 牛田多加志, 古川克子, 浅野秋雄
    • Organizer
      日本機械学会関東支部第24期総会・講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット子宮組織の脱細胞及び再細胞化を促進させるためのバイオレアクターの利用2018

    • Author(s)
      Charoensombut Narintadeach, Kim Jeonghyun, 河鰭公祥, 武田周, 原田貴之, 木村剛, 岸田晶夫, 牛田多加志, 古川克子
    • Organizer
      日本機械学会関東支部第24期総会・講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] エレクトロスピニング法を用いた小口径人工血管担体製作装置の開発2018

    • Author(s)
      本多 理, Johannes Mehtonen Teemu, 増本憲泰, 古川克子, 牛田 多加志
    • Organizer
      日本機械学会関東支部第24期総会・講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 静水圧負荷下における高解像度ライブイメージング装置の開発2018

    • Author(s)
      丸屋 翔, 牧 功一郎, Montagne Kevin, 古川克子,牛田多加志
    • Organizer
      日本機械学会第57回学生員卒業研究発表講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] テラヘルツ時間領域分光法によるハイドロゲルの水和状態の検出2018

    • Author(s)
      辻本敦司, 桑鶴哲理, 鎌田彩花, 黎 豊, 西澤誠治, 古川克子, 牛田多加志
    • Organizer
      日本機械学会第57回学生員卒業研究発表講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 過大圧縮応力が軟骨細胞・組織に及ぼす影響に関する研究2018

    • Author(s)
      佐々木 光, 黄 文敬, 牛田多加志, 古川克子
    • Organizer
      日本機械学会第57回学生員卒業研究発表講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高静水圧による子宮脱細胞化担体の作製とメカニズムの解明2018

    • Author(s)
      武田 周, Kim Jeonghyun, Narintadeach Charoensombut, 河鰭公祥, 原田貴之, 木村 剛, 岸田晶夫, 古川克子, 牛田多加志
    • Organizer
      日本機械学会第57回学生員卒業研究発表講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子宮脱細胞化マトリクスハイドロゲルの作製と評価2018

    • Author(s)
      河鰭公祥, Kim Jeonghyun, 武田 周, CHAROENSOMBUT Narintadeach, 原田貴之, 木村 剛, 岸田晶夫, 牛田多加志, 古川克子
    • Organizer
      日本機械学会第57回学生員卒業研究発表講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] In vitro and in vivo application of scaffold-free tissue reconstructed by endometrial stromal cells.2017

    • Author(s)
      Jeonghyun Kim, Takayuki Harada, Yasushi Hirota, Takehiro Hiraoka, Osamu Yoshino, Shigeru Saito, Yutaka Osuga, Takashi Ushida, and Katsuko S. Furukawa.
    • Organizer
      TERMIS European Chapter Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reconstruction and in vivo application of scaffold-free tissue using rat endometrial stromal cells.2017

    • Author(s)
      Jeonghyun Kim, Takayuki Harada, Tomohiro Matsunaga, Yasushi Hirota, Takehiro Hiraoka, Osamu Yoshino, Shigeru Saito, Yutaka Osuga, Takashi Ushida, and Katsuko S. Furukawa.
    • Organizer
      26th Congress of the International Society of Biomechanics2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 未成熟関節における周期的静水圧の影響2017

    • Author(s)
      浅野秋雄,牛田 多加志,古川克子
    • Organizer
      日本機械学会2017年度年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Adhesion Restriction of Mesenchymal Stem Cells on Nano Check Pattern.2017

    • Author(s)
      陳滋宇, 石橋直也, Montagne Kevin, 牛田多加志, 古川克子
    • Organizer
      日本機械学会2017年度年次大会,埼玉大学
    • Related Report
      2017 Research-status Report
  • [Presentation] Novel approach of scaffold-free tissue using human endometrial stromal cells to facilitate growth of early stage embryo in vitro.2017

    • Author(s)
      Jeonghyun Kim, Takayuki Harada, Yasushi Hirota, Takehiro Hiraoka, Osamu Yoshino, Shigeru Saito, Yutaka Osuga, Takashi Ushida, and Katsuko S. Furukawa
    • Organizer
      2017 Annual Meeting of the Japan Society of Mechanical Engineering
    • Related Report
      2017 Research-status Report
  • [Presentation] Patterns of cell death in porcine articular cartilage exposed to excessive stress.2017

    • Author(s)
      黄文敬, Mia Warner, 佐々木光, 古川克子, 牛田多加志
    • Organizer
      第44回日本臨床バイオメカニクス学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 軟骨前駆細胞における過大静水圧刺激によるマイクロRNA miR-155 の変動の検討2017

    • Author(s)
      モンターニュ ケヴィン, 古川 克子, 牛田 多加志
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 過大応力負荷に対する関節軟骨の応答2017

    • Author(s)
      黄 文敬, Warner Mia, 佐々木 光, 古川 克子, 牛田 多加志
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 静水圧負荷が軟骨細胞の DNA 損傷に及ぼす影響に関する検討2017

    • Author(s)
      牧 功一郎, 古川 克子, 牛田 多加志
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Differentiation control of mesenchymal stem cells on nanoscale.2017

    • Author(s)
      陳 滋宇, 石橋 直也, Montagne Kevin, 牛田 多加志, 古川 克子
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 未成熟関節における周期的静水圧の影響2017

    • Author(s)
      浅野 秋雄, 牛田 多加志, 古川 克子
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 不妊治療への応用を目指したラット子宮内膜間質細胞由来 Scaffold-Free Tissue の作製とその評価2017

    • Author(s)
      原田 貴之, Jeonghyun Kim, 廣田 泰, 平岡 毅大, 吉野 修, 斎藤 滋, 大須賀 穣, 牛田多加志, 古川 克子
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 酸素徐放性担体による三次元組織内の細胞の生存性向上2017

    • Author(s)
      木田 曉, 中塚 俊樹, モンターニュ ケヴィン, 牛田 多加志, 古川 克子
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] テラヘルツ時間領域分光法による軟骨基質水和状態の検出2017

    • Author(s)
      桑鶴 哲理 , 鎌田 彩花, 黎 豊, 西澤 誠治, 古川 克子 , 牛田 多加志
    • Organizer
      日本機械学会第30回バイオエンジニアリング講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 女性研究者と人工臓器・再生医療研究2017

    • Author(s)
      古川克子
    • Organizer
      第55回日本人工臓器学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 脱細胞化組織の作製法と医療・バイオ応用2019

    • Author(s)
      岸田晶夫、山岡哲二、干場隆志 他
    • Total Pages
      229
    • Publisher
      シーエムシー出版
    • ISBN
      9784781314129
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Book] バイオ3Dプリント関連技術の開発と応用2019

    • Author(s)
      古川克子他
    • Total Pages
      269
    • Publisher
      シーエムシー出版
    • ISBN
      9784781314327
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-07-21   Modified: 2021-12-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi