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Development of innovative nanoreactor that induces enzyme cascade reaction in vivo

Research Project

Project/Area Number 17K20094
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering and related fields
Research InstitutionThe University of Tokyo

Principal Investigator

Anraku Yasutaka  東京大学, 大学院工学系研究科(工学部), 特任准教授 (60581585)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords薬剤送達システム / 酵素補充療法 / ナノリアクタ / カスケード反応 / 酵素 / 酵素プロドラッグ療法 / ドラッグデリバリーシステム
Outline of Final Research Achievements

Enzyme replacement therapy (ERT) is a treatment that improves symptoms by supplementing the enzymes that are lacking in the body. Among them, a drug delivery system (DDS) that incorporates a system that delivers an enzyme to a disease site and promotes metabolism is expected as an innovative therapeutic method with particularly low side effects. In this study, the basic technology is a nanoreactor that has an optimal structure as a reaction field for enzymes established so far. In addition to the enzymatic decomposition of the causative substance of the disease, we constructed a reaction field that can purify harmful substances caused by the enzymatic reaction that lead to serious side effects by another enzyme. As a result, we have succeeded in developing a nanoreactor for enzyme replacement therapy that targets tumors and has extremely low side effects.

Academic Significance and Societal Importance of the Research Achievements

本課題で得られた成果は、これまで報告された自己組織化集合体の中でもトップクラスの高い血中循環性能を有しており、「複数の酵素からなるカスケード反応を生体内で誘起する仕組み」は薬剤投与による副作用を著しく低下させる革新的な技術である。これらの技術は、患者のQOLを考えた上でも非常に意義深く、既存の薬剤の薬効を超えるドラッグデリバリーツールに発展することが期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 Other

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results) Presentation (1 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors2019

    • Author(s)
      Suzuki Kazumi、Miura Yutaka、Mochida Yuki、Miyazaki Takuya、Toh Kazuko、Anraku Yasutaka、Melo Vinicio、Liu Xueying、Ishii Takehiko、Nagano Osamu、Saya Hideyuki、Cabral Horacio、Kataoka Kazunori
    • Journal Title

      Journal of Controlled Release

      Volume: 301 Pages: 28-41

    • DOI

      10.1016/j.jconrel.2019.02.021

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self-Assembly of siRNA/PEG-b-Catiomer at Integer Molar Ratio into 100 nm-Sized Vesicular Polyion Complexes (siRNAsomes) for RNAi and Codelivery of Cargo Macromolecules2019

    • Author(s)
      Kim Beob Soo、Chuanoi Sayan、Suma Tomoya、Anraku Yasutaka、Hayashi Kotaro、Naito Mitsuru、Kim Hyun Jin、Kwon Ick Chan、Miyata Kanjiro、Kishimura Akihiro、Kataoka Kazunori
    • Journal Title

      Journal of the American Chemical Society

      Volume: 141 Issue: 8 Pages: 3699-3709

    • DOI

      10.1021/jacs.8b13641

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Therapeutic polymersome nanoreactors with tumor-specific activable cascade reactions for cooperative cancer therapy.2019

    • Author(s)
      W. Ke, J. Li, F. Mohammed, Y. Wang, K. Tou, X. Liu, P. Wen, H. Kinoh, Y. Anraku, H. Chen, K. Kataoka, Z. Ge,
    • Journal Title

      ACS Nano

      Volume: 13 Pages: 2357-2369

    • DOI

      10.1021/acsnano.8b09082

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] ほったらかしで健康になる? -体内ナノマシンによる医療革命-2018

    • Author(s)
      安楽泰孝
    • Organizer
      科学未来館 トークセッション(招待講演)
    • Related Report
      2018 Research-status Report
    • Invited
  • [Remarks] 申請者の所属研究室HP (東京大学カブラル研究室)

    • URL

      http://www.bmc.t.u-tokyo.ac.jp

    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学大学院バイオエンジニアリング専攻 カブラル研

    • URL

      http://www.bmc.t.u-tokyo.ac.jp

    • Related Report
      2018 Research-status Report
  • [Remarks] 東京大学大学院工学系研究科 カブラル研究室

    • Related Report
      2017 Research-status Report

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Published: 2017-07-21   Modified: 2022-01-27  

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