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Design of biomaterials using informatics

Research Project

Project/Area Number 17K20095
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering and related fields
Research InstitutionTokyo Institute of Technology

Principal Investigator

Hayashi Tomohiro  東京工業大学, 物質理工学院, 准教授 (30401574)

Project Period (FY) 2017-06-30 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsバイオマテリアル / ナノバイオテクノロジー / マテリアルズインフォマティクス / 表面科学 / バイオナノテクノロジー / 生体材料 / 細胞接着 / タンパク質吸着
Outline of Final Research Achievements

In this research, we succeeded in designing biomaterials that induce the desired biomolecule / cell response by machine learning using data in a database created based on past experimental data using information science techniques. In particular, aiming at high-precision design of molecules that compose monolayers, we also reported the methodology of material screening using neural networks after the machine learning.

Academic Significance and Societal Importance of the Research Achievements

本研究の挑戦的研究の意義は以下に集約される。経験に基づく試行錯誤的なアプローチでは無く、統計解析に基づいて定量的にバイオマテリアルをデザインするという、全く新しいアプローチを提案した点である。ここでは、材料設計に経験的なフィードバックと試験を繰り返す方法から完全に脱却し、統計解析から得られた化学特性と細胞応答の定量的な相関を逆に辿ることで、要求する細胞応答を誘起するために必要な材料の化学特性を明確に提示することが可能となった。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (96 results)

All 2019 2018 2017 Other

All Journal Article (30 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 24 results,  Acknowledgement Compliant: 1 results) Presentation (60 results) (of which Int'l Joint Research: 16 results,  Invited: 29 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Data-driven Design of Protein- and Cell-resistant Surfaces : A Challenge to Design Biomaterials Using Materials Informatics2019

    • Author(s)
      TAHARA Hiroyuki、KWARIA Rudolf Jason、HAYASHI Tomohiro
    • Journal Title

      Vacuum and Surface Science

      Volume: 62 Issue: 3 Pages: 141-146

    • DOI

      10.1380/vss.62.141

    • NAID

      130007608744

    • ISSN
      2433-5835, 2433-5843
    • Year and Date
      2019-03-10
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy2019

    • Author(s)
      Asai, Takuya Liu, Hanqin Ozeki, Yasuyuki Sato, Shinichi Hayashi, Tomohiro Nakamura, Hiroyuki
    • Journal Title

      Applied Physics Express

      Volume: 12 Issue: 11 Pages: 112004-112004

    • DOI

      10.7567/1882-0786/ab4a5d

    • NAID

      210000157252

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Editorial: Polymer Surface Chemistry: Biomolecular Engineering and Biointerfaces2019

    • Author(s)
      Chen, H. Y. Hayashi, T. Koenig, M. Lai, J. J.
    • Journal Title

      Front Chem

      Volume: 7 Pages: 271-271

    • DOI

      10.3389/fchem.2019.00271

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Formation of long-range-ordered self-assembled monolayers of dodecyl thiocyanates on Au(111) via ambient-pressure vapor deposition2019

    • Author(s)
      Choi, Youngsik Seong, Sicheon Son, Young Ji Han, Seulki Ito, Eisuke Mondarte, Evan Angelo Quimada Chang, Ryongsok Hayashi, Tomohiro Hara, Masahiko Noh, Jaegeun
    • Journal Title

      Colloids and Surfaces A: Physicochemical and Engineering Aspects

      Volume: 583 Pages: 123969-123969

    • DOI

      10.1016/j.colsurfa.2019.123969

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Solvent Effect on the Formation of Octaneselenocyanate Self-Assembled Monolayers on Au(111)2019

    • Author(s)
      Han, S. Park, H. Han, J. W. Yoshizawa, K. Hayashi, T. Hara, M. Noh, J.
    • Journal Title

      J Nanosci Nanotechnol

      Volume: 19 Issue: 8 Pages: 4795-4798

    • DOI

      10.1166/jnn.2019.16706

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular diffusion and nano-mechanical properties of multi-phase supported lipid bilayers2019

    • Author(s)
      Maekawa, T. Chin, H. Nyu, T. Sut, T. N. Ferhan, A. R. Hayashi, T. Cho, N. J.
    • Journal Title

      Phys Chem Chem Phys

      Volume: 21 Issue: 30 Pages: 16686-16693

    • DOI

      10.1039/c9cp02085c

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Raman cell imaging with boron cluster molecules conjugated with biomolecules2019

    • Author(s)
      Mochizuki, Masahito., Sato, Shinichi., Asatyas, Syifa., Lesnikowski, Zbigniew J., Hayashi, Tomohiro., Nakamura, Hiroyuki.
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 41 Pages: 23973-23978

    • DOI

      10.1039/c9ra04228h

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of streptavidin-biotin intermediate metastable states at the single-molecule level using high temporal-resolution atomic force microscopy2019

    • Author(s)
      Mondarte, Evan Angelo., Maekawa, Tatsuhiro., Nyu, Takashi ., Tahara, Hiroyuki., Lkhamsuren, Ganchimeg., Hayashi, Tomohiro.
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 39 Pages: 22705-22712

    • DOI

      10.1039/c9ra04106k

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Formation and Structure of Highly Ordered Self-Assembled Monolayers by Adsorption of Acetyl-Protected Conjugated Thiols on Au(111) in Tetrabutylammonium Cyanide Solution2019

    • Author(s)
      Park, Taesung Kang, Hungu Seong, Sicheon Han, Seulki Son, Young Ji Ito, Eisuke Hayashi, Tomohiro Hara, Masahiko Noh, Jaegeun
    • Journal Title

      The Journal of Physical Chemistry C

      Volume: 123 Issue: 14 Pages: 9096-9104

    • DOI

      10.1021/acs.jpcc.9b00521

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Displacement Processes of 1-Adamanetanethiol Self-Assembled Monolayers on Au(111) by 1-Hexanethiol2019

    • Author(s)
      Son, Y. J. Han, S. Yoshizawa, K. Hayashi, T. Hara, M. Noh, J.
    • Journal Title

      J Nanosci Nanotechnol

      Volume: 19 Issue: 8 Pages: 4732-4735

    • DOI

      10.1166/jnn.2019.16705

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Improvement of the Thermal Stability of Self-Assembled Monolayers of Isocyanide Derivatives on Gold2019

    • Author(s)
      Tsunoi, Azuho., Lkhamsuren, Ganchimeg., Mondarte, Evan Angelo Quimada., Asatyas, Syifa., Oguchi, Masahiro., Noh, Jaegeun., Hayashi, Tomohiro.
    • Journal Title

      The Journal of Physical Chemistry C

      Volume: 123 Issue: 22 Pages: 13681-13686

    • DOI

      10.1021/acs.jpcc.9b02256

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 情報科学を用いたバイオマテリアル設計の可能性2019

    • Author(s)
      ルドルフ ジェイソン クアリア 田原 寛之 張 嶺碩 林 智広
    • Journal Title

      バイオマテリアル-生体材料-

      Volume: 37 Pages: 238-243

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 情報科学を用いたバイオマテリアルの設計2019

    • Author(s)
      林智広, 張嶺碩, Rudolf Jason Kwaria, 田原寛之
    • Journal Title

      有機分子・バイオエレクトロニクス分科会会誌

      Volume: 30 Pages: 228-233

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Molecular-scale structures of the surface and hydration shell of bioinert mixed-charged self-assembled monolayers investigated by frequency modulation atomic force microscopy2018

    • Author(s)
      Araki Yuki、Sekine Taito、Chang Ryongsok、Hayashi Tomohiro、Onishi Hiroshi
    • Journal Title

      RSC Advances

      Volume: 8 Issue: 43 Pages: 24660-24664

    • DOI

      10.1039/c8ra03569e

    • NAID

      120006536967

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Water near bioinert self-assembled monolayers2018

    • Author(s)
      Chang Ryongsok、Asatyas Syifa、Lkhamsuren Ganchimeg、Hirohara Makoto、Mondarte Evan Angelo Quimada、Suthiwanich Kasinan、Sekine Taito、Hayashi Tomohiro
    • Journal Title

      Polymer Journal

      Volume: 50 Issue: 8 Pages: 563-571

    • DOI

      10.1038/s41428-018-0075-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stochastic Binding Process of Blunt-End Stacking of DNA Molecules Observed by Atomic Force Microscopy2018

    • Author(s)
      Taito Sekine, Naoki Kanayama, Kazunari Ozasa, Takashi Nyu, Tomohiro Hayashi, Mizuo Maeda
    • Journal Title

      Langmuir

      Volume: 34 Issue: 49 Pages: 15078-15083

    • DOI

      10.1021/acs.langmuir.8b02224

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Well-Ordered Domains of 4-Fluorobenzenethiol Self-Assembled Monolayers on Au(111) Guided by a Displacement Reaction2018

    • Author(s)
      Sung Taehyun、Seong Sicheon、Han Seulki、Son Young Ji、Ishida Tomoya、Hayashi Tomohiro、Hara Masahiko、Noh Jaegeun
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 18 Issue: 10 Pages: 7053-7057

    • DOI

      10.1166/jnn.2018.15501

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Application of Fuzzy Logic Algorithm to Single-Molecule Force Spectroscopy of the Streptavidin-Biotin System2018

    • Author(s)
      Tahara Hiroyuki、Nyu Takashi、Mondarte Evan Angelo Quimada、Maekawa Tatsuhiro、Hayashi Tomohiro
    • Journal Title

      Advances in Materials Physics and Chemistry

      Volume: 08 Issue: 05 Pages: 217-226

    • DOI

      10.4236/ampc.2018.85014

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] [談話室] 林研究室の紹介: 研究内容・研究室内コミュニケーションについて2018

    • Author(s)
      林智広
    • Journal Title

      応用物理学会 薄膜・表面物理分科会 News Letter

      Volume: 162 Pages: 40-44

    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Journal Article] データ駆動的手法を用いたバイオマテリアルの設計-現状と今後の展望2018

    • Author(s)
      田原寛之 林智広
    • Journal Title

      PHARM STAGE

      Volume: 18 Pages: 43-46

    • Related Report
      2018 Research-status Report
  • [Journal Article] Water near bioinert self-assembled monolayers2018

    • Author(s)
      Ryongsok Chang Syifa Asatyas Ganchimeg Lkhamsuren Makoto Hirohara Evan Angelo Quimada Mondarte Kasinan Suthiwanich Taito Sekine Tomohiro Hayashi
    • Journal Title

      Polymer Journal

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Well-Ordered Domains of 4-Fluorobenzenethiol Self-Assembled Monolayers on Au(111) Guided by a Displacement Reaction2018

    • Author(s)
      Taehyun Sung Sicheon Seong Seulki Han Young Ji Son Tomoya Ishida Tomohiro Hayashi Masahiko Hara Jaegeun Noh
    • Journal Title

      Journal of Nanoscience and Nanotechnology

      Volume: 18

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interactions between protein molecules and the virus removal membrane surface: effects of immunoglobulin G adsorption and conformational changes on filter performance2017

    • Author(s)
      Ryo Hamamoto,Hidemi Ito,Makoto Hirohara,Ryongsok Chang,Tomoko Hongo-Hirasaki,Tomohiro Hayashi
    • Journal Title

      Biotechnology Progress

      Volume: 34 Issue: 2 Pages: 379-386

    • DOI

      10.1002/btpr.2586

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生体適合性をもつ単分子膜~表面・界面科学の手法を利用したメカニズムの解明~2017

    • Author(s)
      張嶺碩,関根泰斗,Syifa Asatyas,Ganchimeg Lkhamsuren,大橋智幸,林智広
    • Journal Title

      化学工業

      Volume: 68 Pages: 886-890

    • Related Report
      2017 Research-status Report
  • [Journal Article] Formation and Structural Changes of 4-Fluorobenzenethiol Self-Assembled Monolayers on Au(111)2017

    • Author(s)
      Myoung-Soo Han Kyungbin Ku Hungu Kang Rina Ohashi Tomohiro Hayashi Masahiko Hara Jaegeun Noh
    • Journal Title

      Jounal of Nanosicence and Nanotechnology

      Volume: 17 Issue: 8 Pages: 5597-5600

    • DOI

      10.1166/jnn.2017.14162

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Damage-Free Tip-Enhanced Raman Spectroscopy for Heat-Sensitive Materials2017

    • Author(s)
      M. Mochizuki, G. Lkhamsuren, K. Suthiwanich, E. A. Mondarte, T. Yano, M. Hara and T. Hayashi,
    • Journal Title

      Nanoscale

      Volume: 9 Issue: 30 Pages: 10715-10720

    • DOI

      10.1039/c7nr02398g

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Standing-Up Phase of Hexanedithiol Self-Assembled Monolayers on Au(111) Induced by Displacement Reaction2017

    • Author(s)
      Myoung-Soo Han Kyungbin Ku Hungu Kang Rina Ohashi Tomohiro Hayashi Masahiko Hara Jaegeun Noh
    • Journal Title

      Jounal of Nanosicence and Nanotechnology

      Volume: 17 Issue: 8 Pages: 5780-5783

    • DOI

      10.1166/jnn.2017.14163

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surface force and vibrational spectroscopic analyses of interfacial water molecules in the vicinity of methoxy-tri(ethylene glycol)-terminated monolayers: mechanisms underlying the effect of lateral packing density on bioinertness2017

    • Author(s)
      Sekine, T. Asatyas, S. Sato, C. Morita, S. Tanaka, M. Hayashi, T.
    • Journal Title

      J Biomater Sci Polym Ed

      Volume: - Issue: 10-12 Pages: 1-13

    • DOI

      10.1080/09205063.2017.1303120

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Raman Imaging Analysis of Local Crystal Structures in LiCoO<sub>2</sub> Thin Films Calcined at Different Temperatures2017

    • Author(s)
      Kosuke Hara,Takaaki Yano,Kouta Suzuki,Masaaki Hirayama,Tomohiro HAYASHI,Ryoji KANNO,Masahiko Hara
    • Journal Title

      Analytical Sciences

      Volume: 33 Issue: 7 Pages: 853-858

    • DOI

      10.2116/analsci.33.853

    • NAID

      130005796374

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication of mechanically stable Au-coatings on probes of atomic force microscopes for nano-mechanical and -optical measurements2017

    • Author(s)
      Lkhamsuren, G. Mochizuki, M. Suthiwanich, K. Hayashi, T.
    • Journal Title

      Thin Solid Films

      Volume: 636 Pages: 478-484

    • DOI

      10.1016/j.tsf.2017.06.046

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of a method for the measurement of Interactions between protein molecules and the virus removal membrane surface: effects of immunoglobulin G adsorption on filter performance2019

    • Author(s)
      Hamamoto, R Ito, H Hirohara, M Chang, R Hongo-Hirasaki, T Hayashi, T
    • Organizer
      ACS Spring 2019 National Meeting & Exposition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Material Informatics for designs of biomaterials2019

    • Author(s)
      Tomohiro Hayash., Rudolf Jason Kwaria., Hiroyuki Tahara.
    • Organizer
      PRESTO International Synposium on Materilas Informatics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of adsorbed proteins on artificial material using MALDI-ToF-MS2019

    • Author(s)
      Makoto Hirohara., Tatsuhiro Maekawa., Takashi Nyu., Taito Sekine., Tomohiro Hayashi.
    • Organizer
      NCTU-Tokyo TECH Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nanoscale Imaging of Molecular Recognition Sites by Amplitude-Modulation Atomic Force Microscopy2019

    • Author(s)
      Tatsuhiro Maekawa., Evan Angelo Quimada Mondarte., Hiroyuki Tahara., Takashi Nyu., Tomohiro Hayashi.
    • Organizer
      NCTU-Tokyo TECH Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Probing receptor-ligand interactions in high temporal resolution using atomic force microscopy2019

    • Author(s)
      Evan Angelo Quimada Mondarte., Tatsuhiro Maekawa., Takashi Nyu., Hiroyuki Tahara., Tomohiro Hayashi.
    • Organizer
      Kyoto Winter School
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nanoscaled Polymer/Solution Interface of Nanophase-Separated Block Copolymer Thin Film By Atomic Force Microscopy2019

    • Author(s)
      Kasinan Suthiwanich Yukari Hiraguchi Takashi Nyu Evan Angelo Quimada Mondarte., Madoka Takai., Tomohiro Hayashi.
    • Organizer
      NCTU-Tokyo TECH Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of single-molecular interaction using a combination of atomic force spectroscopy and machine learning2019

    • Author(s)
      Tahara, H Mondarte, E.A. Maekawa, T. Nyu, T. T, Hayashi
    • Organizer
      Kyoto Winter School
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体分子・細胞に対して抗付着性を示す自己組織化単分子膜の近傍の水の電子構造2019

    • Author(s)
      張嶺碩, 山添康介, 宮脇淳 ,原田慈久, 林智広
    • Organizer
      第80回応用物理学会秋季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 双性イオン型ペプチドからなる自己組織化単分子膜の抗付着性の発現メカニズム2019

    • Author(s)
      張嶺碩 ,関根泰斗, 柏崎亜樹, 村上大樹 ,田中賢, 林智広
    • Organizer
      第80回応用物理学会秋季学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ホウ素クラスター化合物の生細胞への取り込みの誘導ラマンイメージング2019

    • Author(s)
      浅井卓也, 劉寒沁, 小関泰之, 林智広, 佐藤伸一, 中村浩之
    • Organizer
      第66回応用物理学会春期学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Understanding of the origin of bioinertness and design of antifouling surfaces2019

    • Author(s)
      Tomohiro Hayashi
    • Organizer
      Kyoto Winter School 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of molecular processes at biointerfaces using experimental, theoretical, and information techniques2019

    • Author(s)
      Tomohiro Hayashi
    • Organizer
      NCTU-Tokyo TECH Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Experimental and theoretical analyses of biointerfaces and data-driven design of biomaterials2019

    • Author(s)
      Tomohiro Hayashi
    • Organizer
      CHEMISCHE GESELLSCHAFT ZU HEIDELBERG (ハイデルベルグ化学協会)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マテリアルズインフォマティクスによるバイオマテリアル設計への挑戦2019

    • Author(s)
      林智広
    • Organizer
      第3回RIPST講演会 - マテリアルズインフォマティクスへの誘い -
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生体分子吸着・細胞接着を忌避する薄膜技術とデータ科学を用いた材料設計2019

    • Author(s)
      林智広
    • Organizer
      日本学術振興会 第131委員会 研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 表面科学とデータ科学の融合によるバイオ界面の分子プロセスの解析2019

    • Author(s)
      林智広
    • Organizer
      第99回日本化学会春期年会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 実験とデータ科学の融合によるバイオ界面プロセスの解析と材料設計2019

    • Author(s)
      林智広
    • Organizer
      ニューセラミックス懇話会 バイオ関連セラミックス分科会第60回研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 実験とデータ科学を利用した生体-材料界面の解析2019

    • Author(s)
      林智広
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 実験と情報科学の融合によるバイオ界面の分子プロセスの理解とバイオマテリアル設計2019

    • Author(s)
      林智広
    • Organizer
      新化学技術推進協会 ライフサイエンス技術部会 材料分科会講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 表面科学・情報科学を用いた細胞と材料の相互作用の解析2019

    • Author(s)
      林智広
    • Organizer
      日本表面真空学会学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 材料とタンパク質・細胞の界面2019

    • Author(s)
      林智広
    • Organizer
      東ソーライフサイエンス研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 機械学習を用いたフォースカーブの解析と単一分子力学測定への応用2019

    • Author(s)
      林智広
    • Organizer
      日本学術振興会 ナノプローブテクノロジー第167委員会第93回研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] バイオマテリアルの生体適合性のメカニズム解明と情報科学を用いたバイオマテリアル設計2019

    • Author(s)
      林智広
    • Organizer
      R&D支援センターセミナー 医用材料の基礎を踏まえた生体適合性評価
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The Role of Interfacial Water in Bioinertness of Methoxy-Tri(Ethylene Glycol)-Terminated Monolayers Studied by Surface Force and Vibrational Spectroscopy2018

    • Author(s)
      Syifa ASATYAS Taito SEKINE Ryonsok CHANG Tomohiro HAYASHI
    • Organizer
      ChemCYS 2018
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Ultrafast monitoring of the streptavidin-biotin bond dynamics2018

    • Author(s)
      Mondarte, E.A. Maekawa, T. Nyu, T. Tahara, H Hayashi, T.
    • Organizer
      19th International Microscopy Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Closer Look to Streptavidin-biotin Intermolecular Dynamics Directly Probed via Atomic Force Microscopy2018

    • Author(s)
      Evan Angelo Quimada Mondarte Tatsuhiro Maekawa Takashi Nyu Tomohiro Hayashi
    • Organizer
      CEMSupra 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Detection of intermediate transient states of the streptavidin-biotin bond by atomic force microscopy2018

    • Author(s)
      Evan Angelo Q. Mondarte Hiroyuki Tahara Takashi Nyu Tatsuhiro Maekawa Tomohiro Hayashi1
    • Organizer
      第79回応用物理学会秋季学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Single-molecule and real-time measurements of Streptavidin-biotin bond by atomic force microscopy2018

    • Author(s)
      Hiroyuki Tahara Evan Angelo Quimada Mondarte Takashi Nyu Tatsuhiro Maekawa Tomohiro Hayashi
    • Organizer
      10th International Symposium on Organic Molecular Electronics (ISOME)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 双性イオン型ヘプチド単分子膜の抗付着性メカニズムに関する研究2018

    • Author(s)
      張嶺碩 林智広
    • Organizer
      ナノバイオ界面制御技術による機能性材料創成研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体分子で作る生体分子を吸着させない表面2018

    • Author(s)
      張嶺碩 関根泰斗 柏崎亜樹 Syifa Asatyas Ganchimeg Lkhamsuren 村上大樹 田中賢 林智広
    • Organizer
      日本表面真空学会 関東支部講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Toward a Data-Driven Strategy for Designs of Biomaterials2018

    • Author(s)
      Tomohiro Hayashi
    • Organizer
      31st International Microprocesses and Nanotechnology Conference (MNC 2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Interfacial water endowing materials with bioinertness2018

    • Author(s)
      Tomohiro Hayashi
    • Organizer
      The 3rd Aquaphotomics International Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 表面科学的手法を用いた階層的バイオ界面の解析2018

    • Author(s)
      林智広
    • Organizer
      日本学術振興会 ナノプローブテクノロジー第167委員会第88回研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 生体適合性材料の界面プロセスのイメージ化とデータ科学を用いた材料設計2018

    • Author(s)
      林智広
    • Organizer
      日本顕微鏡学会74回学術講演会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 中間水によって引き起こされる界面相互作用2018

    • Author(s)
      林智広
    • Organizer
      鶴田・赤池フォーラム「バイオ界面における水分子の役割の理解と制御」
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Invited
  • [Presentation] バイオ界面における分子プロセス: 抗付着性のメカニズムの解明からデータ科学を利用した材料設計へ2018

    • Author(s)
      林智広
    • Organizer
      神奈川R&D推進協議会 研究会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Invited
  • [Presentation] 実験と情報科学を融合させた生体材料設計2018

    • Author(s)
      林智広
    • Organizer
      帝人分析フォーラム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 生体分子が引き起こす特異的相互作用と抗付着性2018

    • Author(s)
      林智広
    • Organizer
      日本学術振興会第174委員会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 抗生体分子吸着・抗細胞接着性を発現する界面分子プロセスの解析2018

    • Author(s)
      林智広
    • Organizer
      第65回繊維応用技術研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] バイオデバイス・バイオ材料の表面設計~プローブ顕微鏡を用いた解析からデータ科学を利用した材料設計へ2018

    • Author(s)
      林智広
    • Organizer
      日本顕微鏡学会走査型プローブ顕微鏡分科会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] バイオマテリアル(生体材料)表面の評価・解析と材料設計~生体適合性評価・マテリアルズインフォマティクス活用等~2018

    • Author(s)
      林智広
    • Organizer
      情報機構セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 生体親和性材料表面のプローブ顕微鏡による局所水和構造観察2018

    • Author(s)
      林智広
    • Organizer
      ナノバイオ界面制御技術による機能性材料創成研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Interactions of amino acids with gold surfaces analyzed by surface-enhanced infrared absorption spectroscopy2017

    • Author(s)
      Lkhamsuren Ganchimeg Hayashi Tomohiro
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Design of biomaterials using material informatics2017

    • Author(s)
      Tomohiro Hayashi
    • Organizer
      第27回日本MRS-J年次大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Formation and Structure of Self-Assembled Monolayers of Alkaneselenocyanates on Au(111)2017

    • Author(s)
      S. Han, T. Hayashi, M. Hara, J. Noh
    • Organizer
      ISSS-8
    • Related Report
      2017 Research-status Report
  • [Presentation] Physicochemical origin of bioinertness expressed by organic and biological molecule-based self-assembled monolayers2017

    • Author(s)
      T. Hayashi, T. Sekine, S. Asatyas, R. Chang
    • Organizer
      ISSS-8
    • Related Report
      2017 Research-status Report
  • [Presentation] STM Observation on the Formation and Structure of Self-Assembled Monolayers by Adsorption of Unsymmetric Adamantyl Alkyl Disulfides on Au(111)2017

    • Author(s)
      Y.J. Son, T. Hayashi, M. Hara, J. Noh
    • Organizer
      ISSS-8
    • Related Report
      2017 Research-status Report
  • [Presentation] Mechanism underlying bioinertness of nonfouling self-assembled monolayers: surface forces and vibrational analyses2017

    • Author(s)
      Tomohiro HAYASHI, Syifa ASATYAS, Taito SEKINE, Ryongsok CHANG
    • Organizer
      IUMRS-ICAM2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Nanoscale Imaging of Molecular Recognition Sites by Atomic Force Microscopy2017

    • Author(s)
      Takashi NYU, Tatsuhiro MAEKAWA, Kasinan SUTHIWANICH, Tomohiro HAYASHI
    • Organizer
      IUMRS-ICAM2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 双性イオン型ペプチド単分子膜の抗付着性のメカニズム2017

    • Author(s)
      張嶺碩, 関根泰斗, LkhamsurenGanchimeg, 林智広, AsatyasSyifa
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Nanoscale Characterization of Phase-Separated Polymer Thin Film with Static and Dynamic Atomic Force Microscopies2017

    • Author(s)
      Kasinan Suthiwanich, Yukari Hiraguchi, Takashi Nyu, Madoka Takai, Tomohiro HAYASHI
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] ナノメートルスケール空間に挟まれた水の動力学的応答2017

    • Author(s)
      丹生隆, SUTHIWANICHKasinan, 林智広
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] 振幅変調型原子間力顕微鏡法による分子認識部位のナノスケール分解能イメージング2017

    • Author(s)
      前川達洋, 丹生隆, SUTHIWANICHKasinan, 林智広
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Interactions of amino acids with gold surfaces analyzed by surface-enhanced infrared absorption spectroscopy2017

    • Author(s)
      Tomohiro Hayashi, Lkhamsuren Ganchimeg
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Analysis of Correlation between Physicochemical Properties of Self-Assembled Monolayers (SAMs) and Molecular Structures of SAMs Using Artificial Neural Network2017

    • Author(s)
      Jason Kwaria, Tomohiro Hayashi
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Molecular-level understanding of the mechanisms underlying bioinertness of oligo(ethylene glycol)-terminated alkanethiolate monolayers: Surface force and vibrational spectroscopic analyses2017

    • Author(s)
      Asatyas Syifa 関根泰斗 佐藤千香子 森田成昭 田中賢 林智広
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] コロイドプローブ原子間力顕微鏡法による DNA 平滑末端間での特異的な疎水性引力の直接測定2017

    • Author(s)
      関根泰斗, 金山直樹, 尾笹一成, 丹生隆, 林智広, 前田瑞夫
    • Organizer
      第37回表面科学学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Direct measurement of blunt end stacking between DNA layers by atomic force microscopy: For understanding mechanisms underlying self-assembly process of DNA molecules2017

    • Author(s)
      Taito Sekine, Naoki Kanayama, Kazunari Ozasa, Takashi Nyu, Tomohiro Hayashi, Mizuo Maeda
    • Organizer
      IUMRS-ICAM2017
    • Related Report
      2017 Research-status Report
  • [Presentation] 分子レベルで議論する生体不活性特性: メカニズムの解明からデータ科学を利用した材料設計へ2017

    • Author(s)
      林智広
    • Organizer
      日本分析化学会 第 33 回分析化学緑陰セミナー
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Understanding of bioinertness at molecular levels: physical origin of protein and cell resistance2017

    • Author(s)
      Tomohiro Hayashi
    • Organizer
      INST symposium
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 「マテリアルズ・インフォマティクス」の1節 「マテリアルズインフォマティクスによる生体材料表面設計」2018

    • Author(s)
      田原寛之 Rudolf Jason Kwaria 林智広
    • Total Pages
      237
    • Publisher
      技術情報協会
    • ISBN
      9784865021479
    • Related Report
      2018 Research-status Report
  • [Book] マテリアルズ・インフォマティクス~データ科学と計算・実験の融合による材料開発~ 第8節 「マテリアルズ・インフォマティクスを用いたバイオマテリアルの設計の現状と今後の展開2018

    • Author(s)
      田原寛之 Rudolf Jason Kwaria 林智広
    • Total Pages
      237
    • Publisher
      情報機構
    • ISBN
      9784865021479
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Book] マテリアルズ・インフォマティクス2018

    • Author(s)
      田原寛之 Rudolf Jason Kwaria 林智広
    • Publisher
      技術情報協会
    • ISBN
      9784865021479
    • Related Report
      2017 Research-status Report
  • [Remarks] 林研究室WEBサイト

    • URL

      http://lab.spm.jp/

    • Related Report
      2019 Annual Research Report
  • [Remarks] T2R2 林 智広 業績リスト

    • URL

      http://t2r2.star.titech.ac.jp/cgi-bin/researcherinfo.cgi?q_researcher_content_number=CTT100511436

    • Related Report
      2019 Annual Research Report
  • [Remarks] 林研究室WEBパージ

    • URL

      http://lab.spm.jp/

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-07-21   Modified: 2021-02-19  

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