Design of biomaterials using informatics
| Project/Area Number |
17K20095
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering and related fields
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | バイオマテリアル / ナノバイオテクノロジー / マテリアルズインフォマティクス / 表面科学 / バイオナノテクノロジー / 生体材料 / 細胞接着 / タンパク質吸着 |
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| Outline of Final Research Achievements |
In this research, we succeeded in designing biomaterials that induce the desired biomolecule / cell response by machine learning using data in a database created based on past experimental data using information science techniques. In particular, aiming at high-precision design of molecules that compose monolayers, we also reported the methodology of material screening using neural networks after the machine learning.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の挑戦的研究の意義は以下に集約される。経験に基づく試行錯誤的なアプローチでは無く、統計解析に基づいて定量的にバイオマテリアルをデザインするという、全く新しいアプローチを提案した点である。ここでは、材料設計に経験的なフィードバックと試験を繰り返す方法から完全に脱却し、統計解析から得られた化学特性と細胞応答の定量的な相関を逆に辿ることで、要求する細胞応答を誘起するために必要な材料の化学特性を明確に提示することが可能となった。
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] Formation of long-range-ordered self-assembled monolayers of dodecyl thiocyanates on Au(111) via ambient-pressure vapor deposition2019
Author(s)
Choi, Youngsik Seong, Sicheon Son, Young Ji Han, Seulki Ito, Eisuke Mondarte, Evan Angelo Quimada Chang, Ryongsok Hayashi, Tomohiro Hara, Masahiko Noh, Jaegeun
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Journal Title
Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume: 583
Pages: 123969-123969
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Raman cell imaging with boron cluster molecules conjugated with biomolecules2019
Author(s)
Mochizuki, Masahito., Sato, Shinichi., Asatyas, Syifa., Lesnikowski, Zbigniew J., Hayashi, Tomohiro., Nakamura, Hiroyuki.
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Journal Title
RSC Advances
Volume: 9
Issue: 41
Pages: 23973-23978
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Detection of streptavidin-biotin intermediate metastable states at the single-molecule level using high temporal-resolution atomic force microscopy2019
Author(s)
Mondarte, Evan Angelo., Maekawa, Tatsuhiro., Nyu, Takashi ., Tahara, Hiroyuki., Lkhamsuren, Ganchimeg., Hayashi, Tomohiro.
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Journal Title
RSC Advances
Volume: 9
Issue: 39
Pages: 22705-22712
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Improvement of the Thermal Stability of Self-Assembled Monolayers of Isocyanide Derivatives on Gold2019
Author(s)
Tsunoi, Azuho., Lkhamsuren, Ganchimeg., Mondarte, Evan Angelo Quimada., Asatyas, Syifa., Oguchi, Masahiro., Noh, Jaegeun., Hayashi, Tomohiro.
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Journal Title
The Journal of Physical Chemistry C
Volume: 123
Issue: 22
Pages: 13681-13686
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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