The effects of genetic factors on skeletal muscle and joint functions before and after eccentric contractions
| Project/Area Number |
17KK0073
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Hosei University |
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Principal Investigator |
Ochi Eisuke 法政大学, 生命科学部, 准教授 (90468778)
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| Project Period (FY) |
2018 – 2021
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | 遺伝子多型 / アクチニン３ / 筋損傷 / 伸張性収縮 / 関節柔軟性 / 筋硬度 / 筋スティフネス / 筋再生 / 遺伝子改変 / サテライト細胞 / ノックアウト / 線維化 |
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| Outline of Final Research Achievements |
We investigated the effect of ACTN3 R577X SNPs on the muscle and joint functions before and after eccentric exercise in human. As the results, both untrained subjects and athletes showed no change in joint flexibility and muscle stiffness.
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| Academic Significance and Societal Importance of the Research Achievements |
ACTN3遺伝子R577X多型RRが他のグループよりも等尺性筋力が有意に高いことはわかっているが、ACTN3遺伝子R577X多型と関節柔軟性・筋硬度の変化との関連性を明らかにした論文は少なかった。検討の結果、ACTN3遺伝子R577X多型と関節柔軟性・筋硬度とは関連しないことが明らかになった。この結果は、ACTN3遺伝子R577X多型は筋力発揮に関与するものの、関節や筋の硬さには影響しないことを示すデータであった。
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Report
(5 results)
Research Products
(46 results)
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[Presentation] Effect of home-based high-intensity interval training and behavioral modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: the habit-B randomized controlled trial in progress.2021
Author(s)
Tsuji K, Ochi E, Shimizu Y, Kuchiba A, Narisawa T, Okubo R, Ueno T, Shimazu T, Kinoshita T, Suto A, Sakurai N, Matsuoka Y
Organizer
22nd World Congress of Psycho-Oncology & Psychosocial Academy
Related Report
Int'l Joint Research
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[Presentation] Effect of home-based smartphone- supported high-intensity interval training on cardiorespiratory fitness in breast cancer survivors: A randomized controlled trial of the habit-B program.2021
Author(s)
Ochi E, Tsuji K, Narisawa T, Shimizu Y, Kuchiba A, Suto A, Jimbo K, Takayama S, Ueno T, Sakurai N, Matsuoka Y.
Organizer
44nd Annual San Antonio Breast Cancer Symposium (SABCS)
Related Report
Int'l Joint Research
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