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The effects of genetic factors on skeletal muscle and joint functions before and after eccentric contractions

Research Project

Project/Area Number 17KK0073
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionHosei University

Principal Investigator

Ochi Eisuke  法政大学, 生命科学部, 准教授 (90468778)

Project Period (FY) 2018 – 2021
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywords遺伝子多型 / アクチニン3 / 筋損傷 / 伸張性収縮 / 関節柔軟性 / 筋硬度 / 筋スティフネス / 筋再生 / 遺伝子改変 / サテライト細胞 / ノックアウト / 線維化
Outline of Final Research Achievements

We investigated the effect of ACTN3 R577X SNPs on the muscle and joint functions before and after eccentric exercise in human. As the results, both untrained subjects and athletes showed no change in joint flexibility and muscle stiffness.

Academic Significance and Societal Importance of the Research Achievements

ACTN3遺伝子R577X多型RRが他のグループよりも等尺性筋力が有意に高いことはわかっているが、ACTN3遺伝子R577X多型と関節柔軟性・筋硬度の変化との関連性を明らかにした論文は少なかった。検討の結果、ACTN3遺伝子R577X多型と関節柔軟性・筋硬度とは関連しないことが明らかになった。この結果は、ACTN3遺伝子R577X多型は筋力発揮に関与するものの、関節や筋の硬さには影響しないことを示すデータであった。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (46 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (36 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 36 results,  Open Access: 18 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] カリフォルニア大学ロサンゼルス校(米国)2019

    • Year and Date
      2019-03-24
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Accuracy of exercise-based tests for estimating cardiorespiratory fitness and muscle strength in early-stage breast cancer survivors in Japan2022

    • Author(s)
      Tsuji Katsunori、Matsuoka Yutaka J.、Kuchiba Aya、Suto Akihiko、Ochi Eisuke
    • Journal Title

      Supportive Care in Cancer

      Volume: 30 Issue: 5 Pages: 3857

    • DOI

      10.1007/s00520-022-06811-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eccentric exercise causes delayed sensory nerve conduction velocity but no repeated bout effect in the flexor pollicis brevis muscles2021

    • Author(s)
      Ochi Eisuke、Ueda Hisashi、Tsuchiya Yosuke、Nakazato Koichi
    • Journal Title

      European Journal of Applied Physiology

      Volume: 121 Issue: 11 Pages: 3069-3081

    • DOI

      10.1007/s00421-021-04773-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiorespiratory fitness in breast cancer survivors: a randomised controlled trial of home-based smartphone supported high intensity interval training2021

    • Author(s)
      Ochi Eisuke、Tsuji Katsunori、Narisawa Tomomi、Shimizu Yoichi、Kuchiba Aya、Suto Akihiko、Jimbo Kenjiro、Takayama Shin、Ueno Taro、Sakurai Naomi、Matsuoka Yutaka
    • Journal Title

      BMJ Supportive & Palliative Care

      Volume: 12 Issue: 1 Pages: 33

    • DOI

      10.1136/bmjspcare-2021-003141

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of a single bout of resistance exercise on serum Klotho in healthy young men2021

    • Author(s)
      Morishima Takuma、Ochi Eisuke
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 21

    • DOI

      10.14814/phy2.15087

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comorbid insomnia among breast cancer survivors and its prediction using machine learning: a nationwide study in Japan2021

    • Author(s)
      Ueno Taro、Ichikawa Daisuke、Shimizu Yoichi、Narisawa Tomomi、Tsuji Katsunori、Ochi Eisuke、Sakurai Naomi、Iwata Hiroji、Matsuoka Yutaka J
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 52 Issue: 1 Pages: 39-46

    • DOI

      10.1093/jjco/hyab169

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polyunsaturated Fatty Acids, Exercise, and Cancer-Related Fatigue in Breast Cancer Survivors2021

    • Author(s)
      Matsuoka Yutaka、Tsuji Katsunori、Ochi Eisuke
    • Journal Title

      Frontiers in Physiology

      Volume: 12 Pages: 759280-759280

    • DOI

      10.3389/fphys.2021.759280

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oncology care providers’ awareness and practice related to physical activity promotion for breast cancer survivors and barriers and facilitators to such promotion: a nationwide cross-sectional web-based survey2021

    • Author(s)
      Shimizu Yoichi、Tsuji Katsunori、Ochi Eisuke、Okubo Ryo、Kuchiba Aya、Shimazu Taichi、Tatematsu Noriatsu、Sakurai Naomi、Iwata Hiroji、Matsuoka Yutaka J.
    • Journal Title

      Supportive Care in Cancer

      Volume: 30 Issue: 4 Pages: 3105

    • DOI

      10.1007/s00520-021-06706-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis2021

    • Author(s)
      Tidball James G.、Flores Ivan、Welc Steven S.、Wehling-Henricks Michelle、Ochi Eisuke
    • Journal Title

      Experimental Gerontology

      Volume: 145 Pages: 111200-111200

    • DOI

      10.1016/j.exger.2020.111200

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Plasma Eicosapentaenoic Acid Is Associated with Muscle Strength and Muscle Damage after Strenuous Exercise2021

    • Author(s)
      Ochi Eisuke、Yanagimoto Kenichi、Tsuchiya Yosuke
    • Journal Title

      Sports

      Volume: 9 Issue: 1 Pages: 11-11

    • DOI

      10.3390/sports9010011

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-intensity interval training in breast cancer survivors: a systematic review2021

    • Author(s)
      Tsuji Katsunori、Matsuoka Yutaka J.、Ochi Eisuke
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1 Pages: 184-184

    • DOI

      10.1186/s12885-021-07804-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 4-week eicosapentaenoic acid-rich fish oil supplementation partially protects muscular damage following eccentric contractions2021

    • Author(s)
      Tsuchiya Yosuke、Ueda Hisashi、Yanagimoto Kenichi、Kato Ayaka、Ochi Eisuke
    • Journal Title

      Journal of the International Society of Sports Nutrition

      Volume: 18 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s12970-021-00411-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low Dose of β-Hydroxy-β-Methylbutyrate (HMB) Alleviates Muscle Strength Loss and Limited Joint Flexibility following Eccentric Contractions2020

    • Author(s)
      Tsuchiya Yosuke、Ueda Hisashi、Sugita Naoki、Ochi Eisuke
    • Journal Title

      Journal of the American College of Nutrition

      Volume: 40 Issue: 3 Pages: 211-218

    • DOI

      10.1080/07315724.2020.1752330

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Data validation and verification using blockchain in a clinical trial for breast cancer (Preprint)2020

    • Author(s)
      Ueno Taro、Hirano Tomonobu、Motohashi Tomomitsu、Okumura Kosuke、Takajo Kentaro、Kuroki Taiyo、Ichikawa Daisuke、Matsuoka Yutaka、Ochi Eisuke
    • Journal Title

      Journal of Medical Internet Research

      Volume: - Issue: 6 Pages: e18938-e18938

    • DOI

      10.2196/18938

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sitting-induced Endothelial Dysfunction Is Prevented in Endurance-trained Individuals2020

    • Author(s)
      MORISHIMA TAKUMA、TSUCHIYA YOSUKE、UEDA HISASHI、TSUJI KATSUNORI、OCHI EISUKE
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 52 Issue: 8 Pages: 1770-1775

    • DOI

      10.1249/mss.0000000000002302

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Muscular endurance and muscle metabolic responses to 8 weeks of omega‐3 polyunsaturated fatty acids supplementation2020

    • Author(s)
      Morishima Takuma、Tsuchiya Yosuke、Ueda Hisashi、Ochi Eisuke
    • Journal Title

      Physiological Reports

      Volume: 8 Issue: 16

    • DOI

      10.14814/phy2.14546

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maintenance of endothelial function following acute resistance exercise in females is associated with a tempered blood pressure response2020

    • Author(s)
      Morishima Takuma、Padilla Jaume、Tsuchiya Yosuke、Ochi Eisuke
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Issue: 4 Pages: 792-799

    • DOI

      10.1152/japplphysiol.00378.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fast-Velocity Eccentric Cycling Exercise Causes Greater Muscle Damage Than Slow Eccentric Cycling2020

    • Author(s)
      Ueda Hisashi、Tsuchiya Yosuke、Ochi Eisuke
    • Journal Title

      Frontiers in Physiology

      Volume: 11 Pages: 596640-596640

    • DOI

      10.3389/fphys.2020.596640

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eight weeks of fish oil supplementation does not prevent sitting-induced leg endothelial dysfunction2020

    • Author(s)
      Morishima Takuma、Tsuchiya Yosuke、Padilla Jaume、Ochi Eisuke
    • Journal Title

      Applied Physiology, Nutrition, and Metabolism

      Volume: 45 Issue: 1 Pages: 55-60

    • DOI

      10.1139/apnm-2019-0138

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Study protocol for a nationwide questionnaire survey of physical activity among breast cancer survivors in Japan2020

    • Author(s)
      Shimizu Yoichi、Tsuji Katsunori、Ochi Eisuke、Arai Hirokazu、Okubo Ryo、Kuchiba Aya、Shimazu Taichi、Sakurai Naomi、Narisawa Tomomi、Ueno Taro、Iwata Hiroji、Matsuoka Yutaka
    • Journal Title

      BMJ Open

      Volume: 10 Issue: 1 Pages: e032871-e032871

    • DOI

      10.1136/bmjopen-2019-032871

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Physical characteristics and fitness in elite collegiate baseball players in Japan: comparison of pitchers vs. fielders2020

    • Author(s)
      Morishima Takuma、Ito Mamoru、Tsuchiya Yosuke、Ueda Hisashi、Ochi Eisuke
    • Journal Title

      Gazzetta Medica Italiana Archivio per le Scienze Mediche

      Volume: 179 Issue: 3 Pages: 136-142

    • DOI

      10.23736/s0393-3660.19.04048-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Supplementation of eicosapentaenoic acid-rich fish oil attenuates muscle stiffness after eccentric contractions of human elbow flexors2019

    • Author(s)
      Tsuchiya Yosuke、Yanagimoto Kenichi、Ueda Hisashi、Ochi Eisuke
    • Journal Title

      Journal of the International Society of Sports Nutrition

      Volume: 16 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s12970-019-0283-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two and four weeks of β-Hydroxy-β-Methylbutyrate (HMB) supplementations reduce muscle damage following eccentric contractions2019

    • Author(s)
      Tsuchiya Yosuke、Hirayama Kinjiro、Ueda Hisashi、Ochi Eisuke
    • Journal Title

      Journal of the American College of Nutrition

      Volume: 38 Pages: 373-379

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Muscular recruitment is associated with muscular function and swelling following eccentric contractions of human elbow flexors2019

    • Author(s)
      Tsuchiya Yosuke、Ueda Hisashi、Ochi Eisuke
    • Journal Title

      The Journal of Sports Medicine and Physical Fitness

      Volume: 59 Issue: 7 Pages: 1097-1101

    • DOI

      10.23736/s0022-4707.18.09102-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prior cycling exercise does not prevent endothelial dysfunction after resistance exercise2019

    • Author(s)
      Morishima Takuma、Toyoda Masahira、Ochi Eisuke
    • Journal Title

      European Journal of Applied Physiology

      Volume: 119 Issue: 7 Pages: 1663-1669

    • DOI

      10.1007/s00421-019-04154-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short‐term cycling restores endothelial dysfunction after resistance exercise2019

    • Author(s)
      Morishima Takuma、Iemitsu Motoyuki、Ochi Eisuke
    • Journal Title

      Scandinavian Journal of Medicine & Science in Sports

      Volume: - Issue: 8 Pages: 1115-1120

    • DOI

      10.1111/sms.13434

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of home-based high-intensity interval training and behavioural modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: Habit-B study protocol for a randomised controlled trial2019

    • Author(s)
      Tsuji Katsunori、Ochi Eisuke、Okubo Ryo、Shimizu Yoichi、Kuchiba Aya、Ueno Taro、Shimazu Taichi、Kinoshita Takayuki、Sakurai Naomi、Matsuoka Yutaka
    • Journal Title

      BMJ Open

      Volume: 9 Issue: 8 Pages: e030911-e030911

    • DOI

      10.1136/bmjopen-2019-030911

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eicosapentaenoic acid and docosahexaenoic acid in endurance performance and cardiovascular function2019

    • Author(s)
      Ochi Eisuke、Tsuchiya Yosuke
    • Journal Title

      Exercise Science

      Volume: 28 Issue: 4 Pages: 317-323

    • DOI

      10.15857/ksep.2019.28.4.317

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eccentric contraction-induced muscle damage in human flexor pollicis brevis is accompanied by impairment of motor nerve2019

    • Author(s)
      Ochi Eisuke、Ueda Hisashi、Tsuchiya Yosuke、Kouzaki Karina、Nakazato Koichi
    • Journal Title

      Scandinavian Journal of Medicine & Science in Sports

      Volume: 30 Issue: 3 Pages: 462-471

    • DOI

      10.1111/sms.13589

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Muscular recruitment is associated with muscular function and swelling following eccentric contractions of human elbow flexors2019

    • Author(s)
      Tsuchiya Yosuke、Ueda Hisashi、Ochi Eisuke
    • Journal Title

      The Journal of sports medicine and physical fitness

      Volume: -

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two and Four Weeks of β-Hydroxy-β-Methylbutyrate (HMB) Supplementations Reduce Muscle Damage Following Eccentric Contractions.2019

    • Author(s)
      Tsuchiya Yosuke、Hirayama Kinjiro、Ueda Hisashi、Ochi Eisuke.
    • Journal Title

      Journal of the American College of Nutrition

      Volume: 27 Pages: 1-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic Acid-Rich Fish Oil Supplementation Inhibits the Decrease in Concentric Work Output and Muscle Swelling of the Elbow Flexors.2019

    • Author(s)
      Tsuchiya Yosuke、Yanagimoto Kenichi、Morishima Takuma、Ochi Eisuke.
    • Journal Title

      Journal of the American College of Nutrition

      Volume: 38 Pages: 125-131

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) in Muscle Damage and Function2018

    • Author(s)
      Ochi E,Tsuchiya Y
    • Journal Title

      Nutrients

      Volume: 29 Issue: 5 Pages: 1-13

    • DOI

      10.3390/nu10050552

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal variations of bone metabolism and bone mineral density in collegiate alpine skiers2018

    • Author(s)
      Sato T, Sakuraba K, Tsuchiya Y, Maruyama S, Ochi E
    • Journal Title

      Journal of Strength and Conditioning Research

      Volume: 32 Issue: 5 Pages: 1448-1454

    • DOI

      10.1519/jsc.0000000000001987

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Higher Training Frequency Is Important for Gaining Muscular Strength Under Volume-Matched Training2018

    • Author(s)
      Ochi Eisuke、Maruo Masataka、Tsuchiya Yosuke、Ishii Naokata、Miura Koji、Sasaki Kazushige
    • Journal Title

      Frontiers in Physiology

      Volume: 9 Pages: 744-744

    • DOI

      10.3389/fphys.2018.00744

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contralateral repeated bout effect after eccentric exercise on muscular activation2018

    • Author(s)
      Tsuchiya Y,Nakazato K,Ochi E
    • Journal Title

      European Journal of Applied Physiology

      Volume: 118 Issue: 9 Pages: 1997-2005

    • DOI

      10.1007/s00421-018-3933-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] High-intensity resistance exercise with low repetitions maintains endothelial function2018

    • Author(s)
      Morishima Takuma、Tsuchiya Yosuke、Iemitsu Motoyuki、Ochi Eisuke
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 315 Issue: 3 Pages: H681-H686

    • DOI

      10.1152/ajpheart.00281.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Expectations of home-based exercise research for enhancing cancer survivorship care.2022

    • Author(s)
      Matsuoka YJ, Tsuji K, Ochi E.
    • Organizer
      第19回日本臨床腫瘍学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Effect of home-based high-intensity interval training and behavioral modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: the habit-B randomized controlled trial in progress.2021

    • Author(s)
      Tsuji K, Ochi E, Shimizu Y, Kuchiba A, Narisawa T, Okubo R, Ueno T, Shimazu T, Kinoshita T, Suto A, Sakurai N, Matsuoka Y
    • Organizer
      22nd World Congress of Psycho-Oncology & Psychosocial Academy
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between physical activity and fear of cancer recurrence in breast cancer survivors: a nationwide cross-sectional study.2021

    • Author(s)
      Narisawa T, Shimizu Y, Tsuji K, Ochi E, Okubo R, Kuchiba A, Sakurai N, Ueno T, Iwata H, Matsuoka Y.
    • Organizer
      22nd World Congress of Psycho-Oncology & Psychosocial Academy
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 簡易評価法による日本人乳がんサバイバーにおける最高酸素摂取量の予測可能性2021

    • Author(s)
      街勝憲, 松岡豊, 口羽文, 首藤昭彦, 越智英輔
    • Organizer
      第76回日本体力医学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effect of home-based smartphone- supported high-intensity interval training on cardiorespiratory fitness in breast cancer survivors: A randomized controlled trial of the habit-B program.2021

    • Author(s)
      Ochi E, Tsuji K, Narisawa T, Shimizu Y, Kuchiba A, Suto A, Jimbo K, Takayama S, Ueno T, Sakurai N, Matsuoka Y.
    • Organizer
      44nd Annual San Antonio Breast Cancer Symposium (SABCS)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-intensity interval training in breast cancer survivors: A systematic review.2021

    • Author(s)
      Tsuji K, Matsuoka YJ, Ochi E.
    • Organizer
      44nd Annual San Antonio Breast Cancer Symposium (SABCS)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Book] Extreme and Rare Sports: Performance Demands, Drivers, Functional Foods, and Nutrition (Chapter 18 Skeletal Muscle Damage and Recovery from Eccentric Contractions)2019

    • Author(s)
      Sourya Datta、Debasis Bagchi、Ochi Eisuke、Tsuchiya Yosuke
    • Total Pages
      388
    • Publisher
      CRC Press
    • ISBN
      9781138091443
    • Related Report
      2019 Research-status Report
  • [Book] 筋肉研究最前線 : 代謝メカニズム、栄養、老化・疾病予防、科学的トレーニング法(第7章1節 筋損傷を抑制するためのEPA・DHAの摂取について)2019

    • Author(s)
      森谷 敏夫、越智 英輔
    • Total Pages
      342
    • Publisher
      エヌ・ティー・エス(NTS)
    • ISBN
      9784860436155
    • Related Report
      2019 Research-status Report
  • [Remarks] 大学教員業績

    • URL

      http://kenkyu-web.i.hosei.ac.jp/Profiles/101/0010066/profile.html

    • Related Report
      2020 Research-status Report

URL: 

Published: 2018-01-25   Modified: 2023-01-30  

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